Aerobic Exercises Versus Sub Occipital Myofascial Release on Memory Function in Females With Premenstrual Syndrome.

NCT07684495 | Not Yet Recruiting

• 1 other identifier: P.T.REC/012/006325
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This study will be conducted to investigate the effect of aerobic exercises versus sub occipital Myofascial release on memory functions in females with premenstrual syndrome.

Conditions

Premenstrual Syndrome

Outcome Measures

Primary Outcomes (2)

• Memory function

  Assessment of memory function will be done by the free recall test. The word list will contain 10 words selected randomly. These words would be administered to the patient one by one with interval time 1 second between each word with total words presentation time 10 seconds. The presentation of these words will be though a digital screen using a designed video showing these words arranged in order with a fixed interval 1 second between each word. The patient will be instructed immediately to recall these words verbally at any order. The total score is 10 and one point will be accounted for each word will be recalled correctly

  6 weeks

• Prospective and retrospective memory questionnaire (PRMQ)

  It will be used to assess memory functions. The measure consists of 16 individual items. The Structure of the PRMQ consists of 16 Items total , each item is rated on a 5-point scale (1 = Never , 2 = Rarely , 3 = Sometimes , 4 = Often , 5 = Very Often). These 16 items, evenly divided into 8 prospective memory items and 8 retrospective memory items. Each item describes a common memory lapse, giving a high score to an item means a high memory deficits at that item. The total score ranges from 16 to 80, with higher scores indicating a greater frequency of memory lapse and deficit.

  6 weeks

Secondary Outcomes (2)

• Perceived Stress Scale (PSS)

  6 weeks

• Cervical pain intensity

  6 weeks

Study Arms (2)

Aerobic exercise group

EXPERIMENTAL

The participants will receive aerobic exercise program for 30 minutes, 3 sessions per week for 6 weeks.

Other: Aerobic exercise

Sub occipital myofascial release group

EXPERIMENTAL

The participants will receive sub occipital myofascial release treatment 3 sessions per week for 6weeks.

Other: Sub occipital myofascial release

Interventions

Aerobic exercise OTHER

A moderate-intensity aerobic exercise session on a treadmill consists of three phases: warm-up, active phase, and cool-down. The warm-up lasts 5-10 minutes and involves walking at minimum speed (2.0 - 3.0 km/h) with a slight incline (1 -2%) or as tolerated. The active phase, lasting 20-30 minutes, maintains a brisk walking or light jogging pace with moderate speed (4.5-6.5 km/h) or as tolerated. This phase can include steady-state jogging or intervals of walking and jogging to sustain cardiovascular engagement. Finally, the cool-down phase lasts 5-10 minutes, where the speed is gradually reduced to 2.0 - 3.0 km/h, allowing the heart rate to decrease safely.

Aerobic exercise group

Sub occipital myofascial release OTHER

The patient will be asked to take a supine position, and a pillow will be placed under the patient's head for comfort until starting the procedure, the patient will be instructed to be relaxed, then the therapist will sit at the head of the bed and will place both hands underneath the patient's head in the occipital region. The therapist should then feel for the occipital ridge along the scalp and move the hands slightly caudal until the muscle is felt. The therapist then will flex the fingers upward against the suboccipital muscles and this position will be hold for 3 to 5 minutes or until significant muscle tension will be released.

Sub occipital myofascial release group

Eligibility Criteria

• Age: 18 Years - 30 Years
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Females with premenstrual syndrome and memory function deficits have to meet the following criteria in order to participate in this study:
• Their age ranged from 18 to 30 years old.
• Their body mass index (BMI) ranged from 18.5 - 30 kg/cm2.

You may not qualify if:

• Any medications that can affect central nervous system or memory function.
• Any neurological disorders affect their memory function.
• Pregnant women.
• Daily smokers.
• Had a concussion or head trauma within the past 30 days.
• Took any illegal drugs or alcohol within the past 30 days.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Gehad Mohamed Ali

Hurghada, Egypt

Location

MeSH Terms

Conditions

Premenstrual Syndrome

Interventions

Exercise

Condition Hierarchy (Ancestors)

Menstruation Disturbances; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Elham Hassan, As Professor

  Cairo University

  STUDY DIRECTOR

• Amel Youssef, Professor

  Cairo University

  STUDY CHAIR

Central Study Contacts

Gehad Ali, Bachelor

CONTACT

01140675084; jihad7mohammad7@gmail.com

Asmaa Mohammed, PHD

CONTACT

01005199498; Asmaa.smsm1997@icloud.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: June 29, 2026
• First Posted: July 6, 2026
• Study Start: July 3, 2026
• Primary Completion (Estimated): September 20, 2026
• Study Completion (Estimated): September 30, 2026
• Last Updated: July 6, 2026

Record last verified: 2026-06

Locations

EG (1)