NCT07700797

Brief Summary

This randomized interventional study compares the analgesic efficacy of Adductor Canal Block combined with Infiltration of the Posterior Capsule of the Knee (IPCAK) versus the 4-in-1 block technique in patients undergoing knee surgery. Twenty-four patients were randomly allocated into two equal groups. The primary objective is to compare postoperative pain scores and analgesic requirements. Secondary outcomes include time to first rescue analgesia, total analgesic consumption, motor function preservation, and block-related complications.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
24

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jun 2026

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 22, 2026

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 22, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 22, 2026

Completed
16 days until next milestone

First Submitted

Initial submission to the registry

July 8, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

July 14, 2026

Completed
Last Updated

July 17, 2026

Status Verified

July 1, 2026

Enrollment Period

Same day

First QC Date

July 8, 2026

Last Update Submit

July 16, 2026

Conditions

Knee SurgeriesTotal Ankle ArthroplastyAnterior Cruciate Ligament (ACL) TearPosterior Cruciate Ligament Tear

Keywords

Adductor canal blockIPACK4 in 1 blockKnee surgeriesPostoperative analgesiaRegional anesthesiaUltrasound guided nerve block

Outcome Measures

Primary Outcomes (1)

  • Postoperative pain intensity measured by Visual Analog Scale (VAS)

    Postoperative pain will be assessed using the Visual Analog Scale (VAS) at rest and during movement at predetermined postoperative time points

    24 hours after surgery

Secondary Outcomes (3)

  • Total opioid consumption

    First 24 hours after surgery

  • Time to first rescue analgesia

    Within 24 hours after surgery

  • Patient satisfaction with postoperative analgesia

    24 hours after surgery

Study Arms (2)

Adductor canal block+ IPACK

EXPERIMENTAL

Patients receive ultrasound-guided Adductor Canal Block combined with Infiltration of the Posterior Capsule of the Knee (IPCAK) for postoperative analgesia after knee surgery

Procedure: Adductor canal block with IPACK

4 in 1 block

EXPERIMENTAL

Patients receive ultrasound-guided 4-in-1 block for postoperative analgesia after knee surgery.

Procedure: 4 in 1 block

Interventions

Adductor canal block with IPACKPROCEDURE

Ultrasound-guided Adductor Canal Block combined with IPCAK block

Adductor canal block+ IPACK
4 in 1 blockPROCEDURE

Ultrasound-guided 4-in-1 block technique.

4 in 1 block

Eligibility Criteria

Age21 Years - 64 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • \. Patients or caregivers acceptance. 2. Age : 21 - 64 years 3. Sex : both ( males \& females). 4. Physical status: ASA І \& II. 5. BMI 18.5-30 kg/m2. 6. Type of operations : elective surgery. 7. Type of anesthesia: unilateral intrathecal anesthesia. 8. Patients undergoing elective knee surgery under unilateral spinal anesthesia 9. Duration of surgery within 2 hr.

You may not qualify if:

  • Known history of allergy to study drug Coagulopathies or taking drugs affecting coagulation.. Contraindications for peripheral nerve block (PNB) and spinal anesthesia (SA) (coagulation defects, infection at the puncture site), bone degenerative disease and posttraumatic condition of the spine, dementia and severe visual or auditory disorder.
  • Current severe psychiatric disease, alcoholism or drug dependence. Subjects with history previous knee surgery, osteoarthritis, malformation or tumors (including Baker's cyst), which could alter the normal anatomy of the popliteal fossa

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Medicine, Zagazig University Hospitals

Zagazig, Sharqia Province, 055, Egypt

Location

MeSH Terms

Conditions

Lacerations

Condition Hierarchy (Ancestors)

Wounds and Injuries

Study Officials

  • Abdalla Mohamed Goda, MD

    Faculty of Medicine, Zagazig University

    STUDY CHAIR

  • Yasser Mohamed Naser, MD

    Faculty of Medicine, Zagazig University

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 8, 2026

First Posted

July 14, 2026

Study Start

June 22, 2026

Primary Completion

June 22, 2026

Study Completion

June 22, 2026

Last Updated

July 17, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will not share

Locations

EG(1)