NCT07700732

Brief Summary

This randomized clinical trial evaluates the effect of UV photofunctionalization and hyaluronic acid on dental implants placed in the posterior maxilla. Clinical and radiographic outcomes will be assessed during follow-up

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Oct 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2025

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2026

Completed
7 days until next milestone

First Submitted

Initial submission to the registry

July 8, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

July 14, 2026

Completed
18 days until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2026

Completed
Last Updated

July 14, 2026

Status Verified

July 1, 2026

Enrollment Period

9 months

First QC Date

July 8, 2026

Last Update Submit

July 8, 2026

Conditions

Tooth LossSurface TreatmentDelayed ImplantImplant PlacementUV Dental ImplantHyaluronic Acid (HA)

Keywords

PhotofunctionalizationUltraviolet (UV) treatmentHyaluronic acidDental implantsPosterior maxillaOsseointegrationImplant stability

Outcome Measures

Primary Outcomes (2)

  • Hard Tissue (peri-implant bone)

    Marginal bone loss will be assessed using CBCT measured in mm.

    - Immediately postoperative - 3 months after implant placement - 9 months after implant placement.

  • Implant Stability

    Implant stability will be evaluated using Osstell device based on resonance frequency analysis (ISQ values).

    -immediately after implant placement -2 weeks postoperatively -4 weeks postoperatively - 3 months postoperatively - 9 months postoperatively

Secondary Outcomes (2)

  • Soft Tissue

    -After 3 months postoperatively. -After 9 months postoperatively.

  • Peri-implant probing depth

    After 3 months postoperatively. -After 9 months postoperatively.

Study Arms (3)

Study Group 1

EXPERIMENTAL

20 non-UV activated implants were inserted into the prepared osteotomy site in posterior maxilla.

Procedure: Delayed dental implant placement without photofunctionalization.

Study group 2

EXPERIMENTAL

20 UV activated implants were inserted into the prepared osteotomy site in posterior maxilla.

Procedure: Delayed dental Implant photofunctionalization before placement

Study Group 3

EXPERIMENTAL

20 UV activated implants with Hyaluronic acid applied topically on implants surface and into the prepared osteotomy sites in posterior maxilla.

Procedure: Delayed dental Implant photofunctionalization and hyaluronic acid application before placement.

Interventions

Delayed dental implant placement without photofunctionalization.PROCEDURE

Delayed dental implants placed without photofunctionalization or hyaluronic acid in the posterior maxilla.

Study Group 1
Delayed dental Implant photofunctionalization before placementPROCEDURE

Delayed dental implants photofunctionalized with UV light before placement in the posterior maxilla.

Study group 2
Delayed dental Implant photofunctionalization and hyaluronic acid application before placement.PROCEDURE

Delayed dental implants photofunctionalized with UV light and treated with hyaluronic acid before placement in the posterior maxilla.

Study Group 3

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Patients with missed single tooth or multiple teeth in posterior maxilla.
  • Patients Free from any para-functional habits.
  • Patient with Adequate inter-arch relation and inter-occlusal space to accommodate the prosthetic restoration.
  • Patient with good oral hygiene.
  • Patients Willing to participate in the study's follow-up intervals.

You may not qualify if:

  • Patients with any local or systemic disease that absolute contraindicate implant placement or surgery.
  • Pregnancy.
  • Patients with any pathological lesion or aggressive periodontal disease at the planned surgical site.
  • Patients on drugs that could affect bone healing process such as bisphosphonate.
  • Heavy Smokers for more than 10 cigarettes a day.
  • Uncooperative patients.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Dentistry Mansoura University

Al Mansurah, Egypt

Location

MeSH Terms

Conditions

Tooth Loss

Condition Hierarchy (Ancestors)

Periodontal DiseasesMouth DiseasesStomatognathic DiseasesTooth Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 8, 2026

First Posted

July 14, 2026

Study Start

October 1, 2025

Primary Completion

July 1, 2026

Study Completion

August 1, 2026

Last Updated

July 14, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will not share

Locations

EG(1)