Healthy Volunteer Recruitment and Characterization for NINDS Studies

NCT07700511 | Not Yet Recruiting

• 2 other identifiers: 10002262002262-N
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Background: The National Institute of Neurological Disorders and Stroke (NINDS) often enrolls healthy volunteers in certain studies. These studies allow researchers to look for causes of diseases and disorders by comparing affected people to healthy ones. Prescreening lets volunteers participate in multiple studies without having to repeat the screening tests each time. Having a registry of prescreened volunteers also makes it easier for researchers to reach people willing to participate in their studies. Objective: To create a registry of healthy volunteers who have been prescreened for NINDS research studies. Eligibility: Healthy people aged 18 years and older. Design: Participants will have 1 clinic visit for prescreening. This visit will take about 5 hours. The visit may be spread across 1 to 3 days. Participants will have the following procedures: A physical exam, including height, weight, and vital signs. A review of their medical history and medications. They will also provide personal data such as age, sex, and years of education. An exam of their nervous system. This will include tests of their strength and reflexes, following an object with their eyes, and other tasks. Cognitive tests. These tests will check their memory, attention, and thinking. A magnetic resonance imaging (MRI) scan. They will lie on a table that slides into a cylinder; Magnetic fields will create images of their brain. Handedness. They will complete a questionnaire about what hand they use for most tasks. Participants may remain on the healthy volunteers list for 2 years. If they wish to participate longer, they will need to return to repeat all of the screening tests.

Conditions

Healthy

Keywords

Healthy Volunteer; Healthy Participant; Pre-screening

Outcome Measures

Primary Outcomes (1)

• To screen and create a temporary list of volunteers in good health for participation in NINDS studies (Volunteer List) in order to reduce costs, inconvenience to volunteers, and duplication of effort.

  From enrollment/consent until withdrawal from the registry or study closure.

Study Arms (1)

Healthy volunteers

Healthy volunteers

Eligibility Criteria

• Age: 18 Years - 110 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy Volunteers

You may qualify if:

• To be eligible to participate in this study, an individual must meet all the following criteria:
• Stated interest in, and availability for, participating in NINDS studies and willingness to comply with the procedures of this protocol.
• At least 18 years of age.
• Ability to understand and willingness to sign a written informed consent document.
• Fluent in English, or another language that allows the use of a validated MoCA or MoCA Duo to be completed (see the following list of languages Paper (mocacognition.com) or Digital tools (mocacognition.com))

You may not qualify if:

• An individual who meets any of the following criteria will be excluded from participation in this study:
• Major neurological or neurobehavioral disorder, such as seizure disorder, multiple sclerosis, major depression, or schizophrenia.
• Substance use disorder or illicit substance use.
• Deafness or blindness to a degree which would make participation in studies impossible, e.g., inability to communicate with investigators or read instructions.
• Identified major health concerns (e.g., uncontrolled diabetes mellitus, congestive heart failure, liver cirrhosis, malignancy requiring ongoing cytotoxic chemotherapy, immunotherapy, or radiation) as evidenced by screening medical history.
• Presence of implanted electronic devices, e.g., pacemakers, or other implanted object(s) making MRI unsafe or whose safety cannot be ascertained.
• Inability to tolerate MRI scanning for any reason.
• Pregnancy.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

Location

Related Links

• NIH Clinical Center Detailed Web Page

Study Officials

• Eric M Wassermann, M.D.

  National Institute of Neurological Disorders and Stroke (NINDS)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Eric M Wassermann, M.D.

CONTACT

(301) 496-0151; wassermanne@nih.gov

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 11, 2026
• First Posted: July 14, 2026
• Study Start (Estimated): February 8, 2027
• Primary Completion (Estimated): January 8, 2035
• Study Completion (Estimated): January 8, 2035
• Last Updated: July 14, 2026

Record last verified: 2026-07-08

Locations

US (1)