Effectiveness of Pain Neuroscience Education Along With Neural Mobilization Versus Neural Mobilization Alone on Pain, Functional Disability And Quality of Life In Patients With Diabetic Neuropathic Pain

NCT07695181 | Not Yet Recruiting

• 1 other identifier: IIUI/RERC/ADT/2026/05/265
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This is a randomized controlled trial aims to evaluate the comparative effect of Pain Neuroscience Education combined with neural mobilization versus neural mobilization alone in patients with diabetic neuropathic pain. This study will Compare pain intensity between intervention groups and assess functional disability outcomes. Furthermore, this will evaluate changes in quality of life and to analyze pain-related beliefs following PNE.

Conditions

Diabetic Neuropathic Pain

Outcome Measures

Primary Outcomes (4)

• Pain intensity

  Pain intensity will be evaluated using Numeric Pain Rating Scale

  Baseline to week 6

• Functional disability

  Functional disability will be evaluated using Urdu version of Lower Extremity Functional Scale (LEFS)

  Baseline to week 6

• Quality of life

  Quality of life will be evaluated by World Health Organization Quality Of Life-BREF

  Baseline to week 6

• Central sensitization

  Central sensitization will be evaluated using Central Sensitization Inventory

  Baseline to week 6

Study Arms (2)

Group A - Pain Neurosciences Education combined with Neural Mobilization

EXPERIMENTAL

Pain neuroscience education (PNE) will be delivered through structured educational sessions focusing on pain physiology, neural sensitization, and pain modulation. PNE: 20-30 min (weeks 1-2) → 10 min reinforcement (weeks 3-6) Methods: Simple diagrams, patient-friendly metaphors, video demonstrations. Neural mobilization techniques will be applied following standardized neurodynamic principles and patients' tolerance. Target nerves: Sciatic, tibial \& common peroneal Technique: Slider neurodynamic mobilization Dosage: 10-15 reps × 2-3 sets \| Rest: 30-60 sec between sets Session duration: 15-20 minutes

Other: Pain Neurosciences Education + Neural Mobilization

Group B - Neural Mobilization Alone

ACTIVE COMPARATOR

Neural mobilization techniques will be applied following standardized neurodynamic principles and patients' tolerance. Target nerves: Sciatic, tibial \& common peroneal Technique: Slider neurodynamic mobilization Dosage: 10-15 reps × 2-3 sets \| Rest: 30-60 sec between sets Session duration: 15-20 minutes

Other: Pain Neurosciences Education + Neural Mobilization

Interventions

Pain Neurosciences Education + Neural Mobilization OTHER

In Group A pain neuroscience Education will be given in adjunct with neural mobilization techniques Target nerves: Sciatic, tibial \& common peroneal Technique: Slider neurodynamic mobilization Dosage: 10-15 reps × 2-3 sets \| Rest: 30-60 sec between sets Session duration: 15-20 minutes PNE: 20-30 min (weeks 1-2) → 10 min reinforcement (weeks 3-6) Methods: Simple diagrams, patient-friendly metaphors, video demonstrations

Group A - Pain Neurosciences Education combined with Neural Mobilization; Group B - Neural Mobilization Alone

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 40 years (WHO 2016 criteria) Diagnosed Type II diabetes mellitus Lower limb neuropathic pain ≥ 3 months Pain intensity ≥ 4/10 on NPRS Able to walk independently and follow instructions

You may not qualify if:

• Neurological disorders (e.g. stroke, Guillain-Barré) Lumbar disc herniation with radiculopathy Lower limb surgery or spinal fracture within 6 months Active diabetic foot ulcer Diagnosed cognitive impairment or severe infection

Sponsors & Collaborators

• Ibadat International University, Islamabad: lead

Study Sites (1)

Positive Solution Clinic, Wah Cantt

Rawalpindi, Punjab Province, 46000, Pakistan

Location

Central Study Contacts

Roshan Farman, MSPT

CONTACT

+923188108470; 5012324032@student.iiui.edu.pk

Somiya Naz, PhD scholar

CONTACT

+923315163093; somiyanaz@uipt.iiui.edu.pk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: 2 parallel group; Group A - PNE + Neural Mobilization and Group B - Neural Mobilization Alone

Study Record Dates

• First Submitted: July 6, 2026
• First Posted: July 10, 2026
• Study Start: July 10, 2026
• Primary Completion (Estimated): January 10, 2027
• Study Completion (Estimated): January 20, 2027
• Last Updated: July 10, 2026

Record last verified: 2026-07

Locations

PA (1)