Preoperative Performance Indicators, Preoxygenation and Oxygen Reserve Relationship

NCT07688941 | Not Yet Recruiting

• 1 other identifier: TABED1-26-2498
• Study Type: observational
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this observational study is to evaluate the relationship between preoperative cardiopulmonary performance indicators and preoxygenation efficiency along with oxygen reserve depletion in patients scheduled for elective surgery under general anesthesia. The main questions it aims to answer are: What is the relationship between Hand Grip Strength (HGS) and the time taken for end-tidal oxygen (EtO\_2) to reach 90% during preoxygenation? What is the relationship between the 6-Minute Walk Test (6MWT) distance and the Oxygen Reserve Index (ORI) depletion time during the apnea period? Participants will be asked to perform the following tasks during their preoperative and intraoperative care: Complete a 6-Minute Walk Test (6MWT) to determine preoperative functional capacity. Perform a Hand Grip Strength (HGS) test using a calibrated hand dynamometer to measure muscle strength. Undergo standardized preoxygenation with 100% oxygen via a tight-fitting face mask in the operating room while end-tidal oxygen (EtO\_2) and Oxygen Reserve Index (ORI) levels are continuously monitored.

Conditions

Sarcopenia; Handgrip Strength Test; Preoxygenation

Outcome Measures

Primary Outcomes (2)

• Preoxygenation Efficiency (EtO_2 Time)

  The time taken for end-tidal oxygen (EtO\_2) to reach 90% during preoxygenation.

  From the initiation of preoxygenation (0 seconds) until the EtO_2 values reach 90% (typically within 3 to 5 minutes before anesthesia induction)

• Oxygen Reserve Depletion Time (ORI Time)

  The time duration for the Oxygen Reserve Index (ORI) value to drop below 0.55.

  From the cessation of preoxygenation/initiation of apnea until the ORI drops below 0.55

Secondary Outcomes (2)

• Preoperative Functional Capacity (6MWT)

  Preoperative period

• Preoperative Muscle Strength (HGS)

  Preoperative period

Study Arms (1)

Surgical Patients Evaluated for Cardiopulmonary Performance

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients scheduled for elective surgery at Ankara Bilkent City Hospital, Department of Anesthesiology and Reanimation, who will undergo preoxygenation before anesthesia induction.

You may qualify if:

• Patients aged \>18 years ASA physical status I-III Scheduled for elective surgery under general anesthesia Voluntary written informed consent to participate in the study

You may not qualify if:

• Severe COPD (Chronic Obstructive Pulmonary Disease) or restrictive lung disease NYHA Class III-IV Heart Failure Neuromuscular diseases Upper extremity pathologies affecting hand function (preventing HGS measurement) Orthopedic or neurological conditions preventing the 6-minute walk test (6MWT) Emergency surgeries

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

MeSH Terms

Conditions

Sarcopenia

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Central Study Contacts

Betül Güven Aytaç

CONTACT

+905073578351; drbguven@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assos prof

Study Record Dates

• First Submitted: June 30, 2026
• First Posted: July 7, 2026
• Study Start: July 5, 2026
• Primary Completion (Estimated): September 30, 2026
• Study Completion (Estimated): December 3, 2026
• Last Updated: July 7, 2026

Record last verified: 2026-06