Effect of Ozone Therapy on Marginal Bone Levels Around Dental Implants

NCT07687641 | Completed

• 1 other identifier: HRU-25.05.39
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective split-mouth randomized clinical trial was conducted to evaluate the effect of ozone treatment applied to fresh implant sockets on marginal bone levels and bone microarchitecture following immediate implant placement. Each participant received ozone treatment at one implant site and conventional treatment at the contralateral site according to a randomized allocation. Marginal bone levels and bone microarchitecture were evaluated using cone-beam computed tomography (CBCT) and fractal analysis over a 6-month follow-up period.

Conditions

Effects of Gaseous Ozone on Marginal Bone Levels; Immediate Dental Implant Placement

Keywords

Bone level; Ozone; Osseointegration; Dental Implant; Cone-Beam Computed Tomography

Outcome Measures

Primary Outcomes (1)

• Change in Marginal Bone Level Around Dental Implants

  Marginal bone level was assessed using cone-beam computed tomography (CBCT) to compare implant sites treated with gaseous ozone and control sites after implant placement.

  Baseline and 6 months after implant placement

Study Arms (2)

Gaseous Ozone

EXPERIMENTAL

Implant sites received gaseous ozone application to the fresh implant socket immediately before immediate implant placement. In this split-mouth design, each participant received gaseous ozone at one randomized implant site.

Procedure: Gaseous Ozone Application

Control

ACTIVE COMPARATOR

Implant sites received conventional treatment without gaseous ozone application before immediate implant placement. In this split-mouth design, each participant received the control intervention at the contralateral randomized implant site.

Procedure: Conventional Implant Placement

Interventions

Gaseous Ozone Application PROCEDURE

Gaseous ozone was applied to the fresh implant socket immediately before immediate implant placement.

Gaseous Ozone

Conventional Implant Placement PROCEDURE

Implant placement was performed without gaseous ozone application.

Control

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 years or older.
• Systemically healthy individuals.
• Ability to comply with the study protocol.
• At least two missing teeth in symmetrical areas or different quadrants of the same jaw requiring implant placement.
• Adequate alveolar bone volume for placement of standard diameter (3.5-4.0 mm) and length (8-12 mm) implants with at least 1.5 mm of surrounding bone.
• Soft tissue phenotype ≥2 mm and keratinized mucosal width ≥2 mm at implant sites.
• Written informed consent provided.

You may not qualify if:

• Systemic diseases contraindicating implant surgery.
• Pregnancy.
• Insufficient alveolar bone volume requiring advanced bone augmentation.
• Active oral infection.
• Previous implant failure at the intended implant site.
• Incomplete healing after recent tooth extraction.
• Advanced periodontal disease.
• Smoking.
• Any contraindication to ozone therapy.

Sponsors & Collaborators

• Adiyaman University: lead

Study Sites (1)

Faculty of Dentistry, Adıyaman University

Adıyaman, Merkez, 02030, Turkey (Türkiye)

Location

Study Officials

• METİN ÇALIŞIR, PhD

  Department of Periodontology, Faculty of Dentistry, Adıyaman University, Adıyaman, Turkey

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant in Periodontology

Model Details: This was a prospective split-mouth randomized clinical trial. Each participant received both interventions: one implant site was allocated to gaseous ozone treatment and the contralateral comparable implant site served as the control. The allocation of the intervention side was determined using a computer-generated randomization sequence.

Study Record Dates

• First Submitted: June 30, 2026
• First Posted: July 7, 2026
• Study Start: March 12, 2025
• Primary Completion: May 18, 2026
• Study Completion: May 18, 2026
• Last Updated: July 8, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)