Adjunctive Ozone Therapy for Residual Periodontal Pockets

NCT07604636 | Completed

• 1 other identifier: ATAUNI-OZONEPOCKET-26
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with residual periodontal pockets following non-surgical periodontal therapy remain at risk for disease progression and may require further periodontal surgery. Repeated scaling and root planing (SRP) is commonly used for residual pockets; however, complete elimination of periodontal pathogens is often difficult to achieve. Ozone therapy has antimicrobial, anti-inflammatory, and wound-healing properties that may improve periodontal treatment outcomes. The aim of this randomized controlled clinical trial is to clinically and microbiologically evaluate the adjunctive effects of gaseous ozone application during repeated SRP for residual periodontal pockets in patients undergoing periodontal maintenance therapy. Twenty-six patients diagnosed with stage III or IV periodontitis presenting with residual periodontal pockets ≥5 mm with bleeding on probing will be included. Residual pockets will be randomly assigned to either repeated SRP alone (control group) or repeated SRP combined with ozone application (test group). Clinical periodontal parameters and microbiological findings will be evaluated at baseline, 3 months, and 6 months after treatment.

Conditions

Periodontitis; Residual Periodontal Pocket; Periodontal Pocket; Stage III Periodontitis; Stage IV Periodontitis

Keywords

Ozone Therapy; Scaling and Root Planing; Periodontal Maintenance; Residual Pocket; Pocket Closure; Periodontal Debridement; BANA Test; Periodontal Pathogens

Outcome Measures

Primary Outcomes (1)

• Change in Probing Depth

  Assessment of changes in periodontal probing depth (PD) in residual periodontal pockets following repeated scaling and root planing with or without adjunctive gaseous ozone application.

  Baseline, 3 months, and 6 months after treatment

Secondary Outcomes (3)

• Change in Clinical Attachment Level

  Baseline, 3 months, and 6 months after treatment

• Bleeding on Probing

  Baseline, 3 months, and 6 months after treatment

• BANA Test Results

  Baseline, 3 months, and 6 months after treatment

Study Arms (2)

Repeated Scaling and Root Planing

ACTIVE COMPARATOR

Residual periodontal pockets received repeated scaling and root planing alone following periodontal maintenance therapy.

Procedure: Scaling and Root Planing

Repeated Scaling and Root Planing Plus Ozone

EXPERIMENTAL

Residual periodontal pockets received repeated scaling and root planing combined with gaseous ozone application following periodontal maintenance therapy.

Procedure: Scaling and Root Planing; Device: Gaseous Ozone Application

Interventions

Scaling and Root Planing PROCEDURE

Repeated scaling and root planing of residual periodontal pockets was performed using mini-curettes under local anesthesia following periodontal maintenance therapy.

Also known as: Subgingival Reinstrumentation

Repeated Scaling and Root Planing; Repeated Scaling and Root Planing Plus Ozone

Gaseous Ozone Application DEVICE

Gaseous ozone was applied into residual periodontal pockets using the OzoneDTA device with a periodontal probe tip according to the manufacturer's instructions.

Also known as: Ozone Therapy

Repeated Scaling and Root Planing Plus Ozone

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Systemically healthy individuals
• Patients diagnosed with stage III or IV periodontitis
• Patients undergoing periodontal maintenance therapy
• Presence of at least two residual periodontal pockets ≥5 mm with bleeding on probing
• Presence of radiographic bone loss ≥3 mm
• Plaque Index (PI) \<1 before treatment
• Ability and willingness to attend all follow-up visits
• Written informed consent obtained

You may not qualify if:

• Presence of systemic diseases affecting periodontal healing
• Pregnancy or lactation
• Tobacco or alcohol use
• Use of medications affecting periodontal tissues or wound healing
• Periodontal treatment within the previous 6 months
• Presence of carious lesions or periapical pathology on selected teeth
• Furcation involvement
• Tooth mobility ≥ degree 1
• Restorations on selected teeth

Sponsors & Collaborators

• Ataturk University: lead

Study Sites (1)

Ataturk University Faculty of Dentistry, Department of Periodontology

Erzurum, Turkey (Türkiye)

Location

Related Publications (1)

• Sanz M, Herrera D, Kebschull M, Chapple I, Jepsen S, Beglundh T, Sculean A, Tonetti MS; EFP Workshop Participants and Methodological Consultants. Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline. J Clin Periodontol. 2020 Jul;47 Suppl 22(Suppl 22):4-60. doi: 10.1111/jcpe.13290.

  PMID: 32383274 RESULT

MeSH Terms

Conditions

Periodontitis; Periodontal Pocket

Interventions

Tooth Exfoliation; Root Planing

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Dental Physiological Phenomena; Digestive System and Oral Physiological Phenomena; Dental Scaling; Dental Prophylaxis; Periodontics; Dentistry; Subgingival Curettage; Preventive Dentistry

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Clinical and microbiological measurements were performed by a blinded examiner who was not involved in treatment procedures.
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: This study was designed as a split-mouth randomized controlled clinical trial in which residual periodontal pockets within the same participant were randomly assigned to either repeated scaling and root planing alone or repeated scaling and root planing combined with gaseous ozone application.

Study Record Dates

• First Submitted: May 17, 2026
• First Posted: May 22, 2026
• Study Start: March 15, 2024
• Primary Completion: December 15, 2024
• Study Completion: January 20, 2025
• Last Updated: May 22, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)