Sponsor study identifier
interventional
60
1 country
1
Study Start
July 8, 2026
Actual (reported)Primary Completion
July 8, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
January 8, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The CAPTURE AMI trial is an investigator-initiated, single-centre, two-arm, randomised controlled trial. Patients aged ≥ 18 years who present with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) will be enrolled after angiographic evidence of a high thrombus burden (TIMI thrombus grade ≥ 4) and meeting the inclusion criteria laid out in section 9.2 will be 1:1 randomised to receive either standalone PCI (Arm 1) or adjunct sustained mechanical thrombectomy + PCI (Arm 2). The CAPTURE AMI study will enrol specifically patients with: A. Evidence of high thrombus burden on coronary angiography (TIMI thrombus grade ≥ 4) B. Culprit in an artery with a diameter of 3.0 mm or more. The trial is designed to evaluate the efficacy of sustained mechanical thrombectomy versus standalone PCI in patients with a large thrombus burden assessed angiographically, with a pre-stent thrombus burden (%) as the primary imaging endpoint.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 8, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 25, 2026
Actual (reported)July 7, 2026
Actual (reported)July 8, 2026
Actual (reported)July 8, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
January 8, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Pre stent Thrombus Burden
Pre stent Thrombus Burden (thrombus volume/lumen volume) evaluated by Optical Coherence Tomography
Pre stent implantation (Periprocedural)
Clinical Outcomes
In hospital (Pre-discharge), 30 days & 6 months
Efficacy of thrombus burden reduction
Pre stent implantation (Periprocedural)
Efficacy of thrombus burden reduction
Pre stent Implantation (Periprocedural)
Standalone OCT guided PCI
OCT guided PCI \& Sustained Thrombectomy
Sustained thrombectomy with the Indigo® System CAT™ RX aspiration catheter
Optical Coherence Tomography guided Percutaneous Coronary Intervention
Oxford Heart Centre - John Radcliffe Hospital
Oxford, Oxfordshire, OX3 9DU, United Kingdom
Kotronias RA, Walsh JL, Andreaggi S, Portolan L, Maino A, Marin F, Chai J, Sobirov I, Sheikh M, Cahill TJ, Lucking AJ, Costello M, Fraile Moreno E, Haridas V, Shaji A, Garcia-Garcia HM, Channon KM, Banning AP, Langrish JP, De Maria GL; OxAMI and RETRIEVE AMI Investigators. Stent-Retriever Thrombectomy in STEMI With Large Thrombus Burden: The RETRIEVE AMI Randomized Trial. JACC Adv. 2025 Jul;4(7):101893. doi: 10.1016/j.jacadv.2025.101893. Epub 2025 Jun 23.
Walsh JL, Kotronias RA, Banning AP, De Maria GL. Interventional thrombus modification in STEMI. Nat Rev Cardiol. 2024 Jul;21(7):435-436. doi: 10.1038/s41569-024-01020-2. No abstract available.
First Submitted
June 25, 2026
First Posted
July 7, 2026
Study Start
July 8, 2026
Actual (reported)Primary Completion
July 8, 2027
EstimatedUse of the Methoxyflurane as Pain-killer in the Prehospital Management of Acute Myocardial Infarction
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Kotronias RA, Marin F, Emfietzoglou M, Langrish JP, Lucking AJ, Channon KM, Banning AP, De Maria GL. Rationale and Design of a Randomized Controlled Pilot Trial to Assess Stent Retriever Thrombectomy for Thrombus Burden Reduction in Patients with Acute Myocardial Infarction: The RETRIEVE-AMI Study. Cardiovasc Revasc Med. 2023 Jul;52:75-85. doi: 10.1016/j.carrev.2023.02.012. Epub 2023 Mar 6.
Snir AD, Kotronias RA, Cascone A, Andreaggi S, Shabbir A, Langrish JP, Banning AP, De Maria GL. Rationale and design of a randomized controlled trial to evaluate thrombus modification efficacy of sustained mechanical aspiration thrombectomy in patients with ST Elevation Myocardial Infarction: The CAPTURE AMI study. Cardiovasc Revasc Med. 2026 Oct 7:S1553-8389(26)00399-4. doi: 10.1016/j.carrev.2026.10.002. Online ahead of print.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
January 8, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
July 10, 2026
Record last verified: 2026-06
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Source: ClinicalTrials.gov.
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