Cardiovascular Risk in Patients With Takayasu Arteritis: A Nationwide Population-Based Cohort Study

NCT07686991 | Completed

• 1 other identifier: TAK-CV-2026
• Study Type: observational
• Target: 8,275
• Locations: 1 country
• Sites: 2

Brief Summary

This nationwide observational cohort study compares the risk of major adverse cardiovascular events (MACE) and territory-specific arterial complications between patients with incident Takayasu arteritis and matched general-population controls, and identifies determinants of MACE within the Takayasu arteritis population, including cumulative glucocorticoid exposure, using the French National Health Data System (SNDS).

Conditions

Takayasu Arteritis; Cardiovascular Diseases

Keywords

Takayasu Arteritis; MACE; Inflammation; Atherosclerosis; Cardiovascular risk

Outcome Measures

Primary Outcomes (1)

• Major Adverse Cardiovascular Events (MACE)

  Major Adverse Cardiovascular Events (MACE) Composite of myocardial infarction, ischemic stroke, or all-cause death

  Up to 15 years (January 2010 to December 2024)

Secondary Outcomes (6)

• Coronary events

  Time Frame: Up to 15 years (2010-2024)

• Ischemic stroke

  Time Frame: Up to 15 years (2010-2024)

• All-cause mortality

  Time Frame: Up to 15 years (2010-2024)

• Aortic events

  Up to 15 years (2010-2024)

• Visceral artery events

  Up to 15 years (2010-2024)

Study Arms (2)

Takayasu arteritis cohort

Patients aged 15 to 60 years with an incident hospital diagnosis of Takayasu arteritis (ICD-10 M31.4) recorded between 2010 and 2024 (n=1,655).

Matched general-population controls

General-population controls without Takayasu arteritis, matched 4:1 (exact on sex and region, calipers on year of birth and propensity-score logit), each inheriting the index date of the matched case (n=6,620).

Eligibility Criteria

• Age: 15 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 15 to 60 years hospitalized for incident Takayasu arteritis in France identified from the SNDS database, together with up to four matched general-population controls per case.

You may qualify if:

• Age 15 to 60 years Cases: incident hospital diagnosis of Takayasu arteritis (ICD-10 M31.4) recorded as principal, related, or associated diagnosis between 2010 and 2024 Cases matched 4:1 to general-population controls (exact on sex and region; calipers on year of birth and propensity-score logit) Controls: alive and active in the database at the index date (≥1 reimbursed contact in the prior 365 days), residing in the same region, with no recorded Takayasu arteritis diagnosis

You may not qualify if:

• Cases who could not be matched to at least four eligible general-population controls Age outside the 15 to 60 years range at the index date

Sponsors & Collaborators

• Groupe français d'étude des Maladies Inflammatoires de loeil: lead

Study Sites (2)

APHP_ Hôpital Pitié-Salpêtrière

Paris, France

Location

APHP_ Hôpital Saint-Antoine

Paris, France

Location

Related Publications (3)

• Tuppin P, Rudant J, Constantinou P, Gastaldi-Menager C, Rachas A, de Roquefeuil L, Maura G, Caillol H, Tajahmady A, Coste J, Gissot C, Weill A, Fagot-Campagna A. Value of a national administrative database to guide public decisions: From the systeme national d'information interregimes de l'Assurance Maladie (SNIIRAM) to the systeme national des donnees de sante (SNDS) in France. Rev Epidemiol Sante Publique. 2017 Oct;65 Suppl 4:S149-S167. doi: 10.1016/j.respe.2017.05.004. Epub 2017 Jul 27.

  PMID: 28756037 BACKGROUND

• Scailteux LM, Droitcourt C, Balusson F, Nowak E, Kerbrat S, Dupuy A, Drezen E, Happe A, Oger E. French administrative health care database (SNDS): The value of its enrichment. Therapie. 2019 Apr;74(2):215-223. doi: 10.1016/j.therap.2018.09.072. Epub 2018 Oct 25.

  PMID: 30392702 BACKGROUND

• Guedon AF, Espitia O, Beydon M, Ghrenassia E, Mirault T, Messas E, Tubach F, Seror R, Boccara F, Cohen A, Frikke-Schmidt R, Nordestgaard BG, Dellal A, Fain O, Mekinian A, Carrat F. Cardiovascular risk among Giant cells arteritis patients. Eur J Prev Cardiol. 2026 Jan 14:zwag034. doi: 10.1093/eurjpc/zwag034. Online ahead of print.

  PMID: 41537566 BACKGROUND

MeSH Terms

Conditions

Takayasu Arteritis; Cardiovascular Diseases; Inflammation; Atherosclerosis

Condition Hierarchy (Ancestors)

Aortic Arch Syndromes; Aortic Diseases; Vascular Diseases; Arteritis; Vasculitis; Skin Diseases, Vascular; Skin Diseases; Skin and Connective Tissue Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Arteriosclerosis; Arterial Occlusive Diseases

Study Officials

• Alexis Guedon

  APHP - HOPITAL SAINT ANTOINE

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 30, 2026
• First Posted: July 7, 2026
• Study Start: January 1, 2010
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: July 7, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

FR (2)