- 4th Visit at 17 Years of Cohort STANISLAS - Stanislas Ancillary Study ESCIF

NCT01391442 | Completed DMC

• 1 other identifier: 2010-A01469-30
• Study Type: interventional
• Target: 1,705
• Locations: 1 country
• Sites: 2

Brief Summary

The Stanislas Cohort is a monocentric familial longitudinal cohort comprised of 1006 families (4295 subjects) from the Nancy region recruited in 1993-1995 at the Centre for Preventive Medicine (Centre de Médecine Préventive, CMP), Vandoeuvre lès Nancy for a 5-year periodic health examination, under the auspices of the Caisse Nationale d'Assurance Maladie (CNAM). This cohort was established with the primary objective of investigating gene-gene and gene-environment interactions in the field of cardiovascular diseases, based on the study of inter-individual variability and familial segregation analysis of biological and morphological intermediate phenotypes of cardiovascular risk. The longitudinal nature of this study should enable to take into account the evolution of intermediate phenotypes related to genetic factors throughout the follow-up period. The families, consisting of two parents and at least two biological children, were deemed healthy, free of declared acute and/or chronic illness, in order to assess the effect of genetics on the variability of intermediate phenotypes studied under physiological conditions (without the influence, in the absence) of pathology. The Stanislas Cohort is, both nationally and internationally, the only longitudinal familial cohort of supposedly healthy subjects on such a large scale. Brief summary of ancillary study "Cardiac Functional Indices Comparison Between MRI and Echocardiography" : the ESCIF study is an ancillary study of the Stanislas cohort aiming at comparing in a cohort of supposedly healthy subjects different cardiac functional indices between two different modalities : Echocardiography and MRI. Indeed, new cardiac functional indices have been recently developed in the scope of echocardiography and would be very useful in MRI. In echography they are computed either from tissue Doppler imaging or from a specific image analysis called speckle tracking. These two techniques are accessible in MRI with the Generalized Reconstruction by Inversion of Coupled Systems (GRICS) technology which provides a motion model from which strains and strain rates may be derived and which allow longer acquisition without the constraint of breath holding (mandatory to reach high temporal resolution).

Conditions

Cardiovascular Diseases

Keywords

follow up of troop,; MRI, Echocardiography, Functional indices

Outcome Measures

Primary Outcomes (2)

• investigating gene-gene and gene-environment interactions in the field of cardiovascular diseases

  study of inter-individual variability and familial segregation analysis of biological and morphological intermediate phenotypes of cardiovascular risk

  day 1

• ESCIF ancillary study : pair-wise comparison of functional indices measured in MRI and echocardiography

  day 1

Secondary Outcomes (1)

• ESCIF ancillary study : inter-observer reproducibility of each method (MRI and Echocardiography)

  day 1

Study Arms (1)

family

OTHER

each family, composed of 4 characters at least, is studied

Biological: blood and urine samples; Genetic: blood sample; Other: cardiovascular assessment; Other: Stanislas ancillary study : MRI examination with GRICS technique

Interventions

blood and urine samples BIOLOGICAL

58 ml of blood 120 ml of urine

Also known as: biological analyses, biological collection

family

blood sample GENETIC

11 ml of blood

Also known as: ADN and ARN collection

family

cardiovascular assessment OTHER

echography, echodoppler, measure of blood pressure...

Also known as: cardiovascular risk factors

family

Stanislas ancillary study : MRI examination with GRICS technique OTHER

family

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient having taken part in the STANISLAS troop,
• At least 18 years old,
• Written and signed enlightened assent,
• Ensured social

You may not qualify if:

• Patient unable to understand the informed consent,
• patient under legal protection
• STANISLAS ancillary study:
• Study population = subgroup of 76 subjects from the Stanislas cohort
• Eligibility:
• being member of the Stanislas cohort and participating to 4th visit Specific written and signed enlightened consent for the ESCIF study
• contraindications for MRI examination, possibility of pregnancy

Sponsors & Collaborators

• Pr. Nicolas GIRERD: lead

Study Sites (2)

Centre d'Investigation Clinique -Plurithématique

Nancy, 54500, France

Location

Centre d'Investigation Clinique- INNOVATIONS TECHNOLOGIQUES

Nancy, 54500, France

Location

Related Publications (7)

• Lagrange J, Jahangiri M PhD, Baudry G, Mercier N, Monzo L, Lamiral Z, Duarte K, Ter Maaten JM, Zannad F, Voors AA, Girerd N. Association Between Endothelial Alterations, Cardiac Function, and Outcomes From Health to Heart Failure: Insight From the STANISLAS, MEDIA-DHF, and BIOSTAT-CHF Cohorts. J Am Heart Assoc. 2025 Jun 3;14(11):e040179. doi: 10.1161/JAHA.124.040179. Epub 2025 May 29.

  PMID: 40439171 DERIVED

• Lai TP, Verhulst S, Savage SA, Gadalla SM, Benetos A, Toupance S, Factor-Litvak P, Susser E, Aviv A. Buildup from birth onward of short telomeres in human hematopoietic cells. Aging Cell. 2023 Jun;22(6):e13844. doi: 10.1111/acel.13844. Epub 2023 Apr 28.

  PMID: 37118904 DERIVED

• Kobayashi M, Huttin O, Magnusson M, Ferreira JP, Bozec E, Huby AC, Preud'homme G, Duarte K, Lamiral Z, Dalleau K, Bresso E, Smail-Tabbone M, Devignes MD, Nilsson PM, Leosdottir M, Boivin JM, Zannad F, Rossignol P, Girerd N; STANISLAS Study Investigators. Machine Learning-Derived Echocardiographic Phenotypes Predict Heart Failure Incidence in Asymptomatic Individuals. JACC Cardiovasc Imaging. 2022 Feb;15(2):193-208. doi: 10.1016/j.jcmg.2021.07.004. Epub 2021 Sep 15.

  PMID: 34538625 DERIVED

• Monzo L, Ferreira JP, Lamiral Z, Bozec E, Boivin JM, Huttin O, Lopez-Sublet M, Girerd N, Zannad F, Rossignol P. Isolated diastolic hypertension and target organ damage: Findings from the STANISLAS cohort. Clin Cardiol. 2021 Nov;44(11):1516-1525. doi: 10.1002/clc.23713. Epub 2021 Sep 15.

  PMID: 34523741 DERIVED

• Wagner S, Lioret S, Girerd N, Duarte K, Lamiral Z, Bozec E, Van den Berghe L, Hoge A, Donneau AF, Boivin JM, Merckle L, Zannad F, Laville M, Rossignol P, Nazare JA. Association of Dietary Patterns Derived Using Reduced-Rank Regression With Subclinical Cardiovascular Damage According to Generation and Sex in the STANISLAS Cohort. J Am Heart Assoc. 2020 Apr 7;9(7):e013836. doi: 10.1161/JAHA.119.013836. Epub 2020 Mar 21.

  PMID: 32200718 DERIVED

• Benetos A, Verhulst S, Labat C, Lai TP, Girerd N, Toupance S, Zannad F, Rossignol P, Aviv A. Telomere length tracking in children and their parents: implications for adult onset diseases. FASEB J. 2019 Dec;33(12):14248-14253. doi: 10.1096/fj.201901275R. Epub 2019 Oct 25.

  PMID: 31652401 DERIVED

• Ferreira JP, Girerd N, Bozec E, Machu JL, Boivin JM, London GM, Zannad F, Rossignol P. Intima-Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population-Based Cohort (STANISLAS Cohort Study). J Am Heart Assoc. 2016 Jun 16;5(6):e003529. doi: 10.1161/JAHA.116.003529.

  PMID: 27312804 DERIVED

MeSH Terms

Conditions

Cardiovascular Diseases

Interventions

Blood Specimen Collection; Biological Oxygen Demand Analysis; Heart Disease Risk Factors

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques; Environmental Monitoring; Environmental Exposure; Environmental Pollution; Public Health; Environment and Public Health; Public Health Practice; Risk Factors; Risk; Probability; Statistics as Topic; Epidemiologic Methods; Causality; Epidemiologic Factors; Quality of Health Care; Health Care Quality, Access, and Evaluation; Health Care Evaluation Mechanisms

Study Officials

• Faiez ZANNAD, PU, PH

  CHU Nancy, CIC-P, INSERM

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: May 12, 2011
• First Posted: July 12, 2011
• Study Start: July 1, 2011
• Primary Completion: July 1, 2016
• Study Completion: July 1, 2016
• Last Updated: March 28, 2024

Record last verified: 2024-02

Locations

FR (2)