LifeBio Memory: Development of a Reminiscence Therapy Online Platform With Machine Learning to Increase Engagement

NCT07685067 | Not Yet Recruiting

• 2 other identifiers: koh52R44AG069566-03A1
• Study Type: interventional
• Target: 168
• Locations: 0 countries
• Sites: N/A

Brief Summary

LifeBioMEMORY (LBM) is a reminiscence therapy (RT) mobile application that captures older adults' life stories in their own voices to promote social engagement and psychosocial well-being. This study will develop and evaluate an enhanced multilingual LBM app for community-dwelling, diverse older adults with mild cognitive impairment (MCI) or at risk of MCI and their informal caregivers, including Hispanic/Latino, Asian American (as one of subgroups, Korean), Black or African American, and non-Hispanic White populations. The app provides culturally tailored life story prompts with audio and visual cues to encourage reminiscence and storytelling. The intervention aims to improve quality of life, reduce depressive symptoms and loneliness, and strengthen caregiver-care recipient relationships, with the potential to provide an accessible, non-pharmacological approach to supporting cognitive and emotional well-being.

Conditions

Mild Cognitive Impairment

Keywords

Mild Cognitive Impairment; Reminiscence

Outcome Measures

Primary Outcomes (1)

• Primary Outcome

  Health-Related Quality of Life (SF-12 Physical and Mental Component Summary Scores)

  Assessments will be conducted at baseline, 6 weeks, and 10 weeks.

Secondary Outcomes (3)

• Center for Epidemiologic Studies Depression Scale (CES-D)

  Assessments will be conducted at baseline, 6 weeks, and 10 weeks.

• Relationship Closeness Scale (RCS)

  Assessments will be conducted at baseline, 6 weeks, and 10 weeks.

• UCLA Loneliness Scale

  Assessments will be conducted at baseline, 6 weeks, and 10 weeks.

Study Arms (2)

LifeBio Memory (LBM) digital reminiscence intervention

EXPERIMENTAL

Participants will access the LifeBio Memory (LBM) digital reminiscence platform using a mobile phone or tablet. Informal caregivers will complete a brief training. During Weeks 1-2, dyads will complete at least two weekly sessions recording the older adult's life stories using structured prompts. During Weeks 3-5, dyads will complete one weekly reminiscence and social engagement session. In Week 6, participants will receive personalized LifeBio story materials, including a Life Story Book, Snapshot, and story summary.

Other: LifeBio Memory (LBM) digital reminiscence intervention

Waitlist Control (Delayed LBM digital reminiscence intervention)

ACTIVE COMPARATOR

Participants will receive general education on brain health and information about available local social services during the control period. After the control period, participants will participate in the LifeBio Memory (LBM) App intervention.

Other: LifeBio Memory (LBM) digital reminiscence intervention

Interventions

LifeBio Memory (LBM) digital reminiscence intervention OTHER

LifeBioMEMORY (LBM) is a multilingual digital reminiscence therapy platform that guides older adults through life story sharing using culturally relevant prompts, photos, and voice recording in Spanish, Korean, or English. The app includes "My Story" and "Fun Things to Do" features to support reminiscence and engagement while capturing personal narratives. Using machine learning, LBM generates personalized Life Story Books and summaries in the preferred language of the older adult and informal caregiver, with electronic and printed copies available. The intervention is designed to promote social engagement, strengthen caregiver relationships, and support person-centered care.

LifeBio Memory (LBM) digital reminiscence intervention; Waitlist Control (Delayed LBM digital reminiscence intervention)

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• Self-identified as Hispanic/Latino, Korean, Black/African American, and Non-Hispanic White
• Speak and read Spanish, Korean, or English
• Aged 60 years and older, with Montreal Cognitive Assessment (MoCA) test scores ranging 18-30 (with MCI: 18-25, or at risk for MCI: 26-30)
• Have a local or in-home informal caregiver who can participate who is age 18 or older
• No pre-existing acute psychotic disease or critical illness
• Consent to participate
• Self-identified as Hispanic/Latino, Korean, Black/African American, and Non-Hispanic White
• Speak and read Spanish, Korean, or English
• Aged 18 years and older
• Currently serving as the primary informal caregiver for older adults aged 60 or older
• No pre-existing acute psychotic disease or critical illness
• Consent to participate

Sponsors & Collaborators

• George Mason University: lead
• National Institute on Aging (NIA): collaborator

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Kyeung Mi Oh, PhD

CONTACT

703 993 4550; koh5@gmu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 17, 2026
• First Posted: July 6, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): May 31, 2028
• Study Completion (Estimated): May 31, 2028
• Last Updated: July 6, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share