Short-Axis Versus Long-Axis Ultrasound-Guided Peripheral IV Cannulation in Adults

NCT07683611 | Completed

• 1 other identifier: 962/LRH/MTI
• Study Type: interventional
• Target: 222
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized study compared two ultrasound-guided techniques for placing a peripheral intravenous cannula in adults aged 20 to 60 years who required intravenous access. Participants were assigned equally to either the short-axis out-of-plane approach or the long-axis in-plane approach. The study evaluated whether the techniques differed in successful cannulation. It also compared cannulation time, number of attempts, and immediate complications, including arterial puncture, extravasation, and haematoma.

Conditions

Peripheral Venous Catheterization

Keywords

Ultrasound-Guided Peripheral Intravenous Cannulation; Short-Axis Out-of-Plane Approach; Long-Axis In-Plane Approach; Peripheral Intravenous Access; Interventional Ultrasonography

Outcome Measures

Primary Outcomes (1)

• Successful Peripheral Intravenous Cannulation

  Cannulation was considered successful when the catheter advanced without resistance, blood returned freely into the hub, and saline could be flushed without local swelling. The outcome was recorded as successful or unsuccessful.

  Immediately following the assigned cannulation procedure

Secondary Outcomes (1)

• Cannulation Time

  uring the assigned cannulation procedure

Study Arms (2)

Short-Axis Out-of-Plane Approach

EXPERIMENTAL

Participants underwent ultrasound-guided peripheral intravenous cannulation with the probe positioned perpendicular to the target vein to obtain a transverse image. The needle was advanced using an out-of-plane technique.

Procedure: Short-Axis Out-of-Plane Ultrasound-Guided Cannulation

Long-Axis In-Plane Approach

ACTIVE COMPARATOR

Participants underwent ultrasound-guided peripheral intravenous cannulation with the probe positioned parallel to the target vein to obtain a longitudinal image. The needle was advanced in plane while maintaining visualization of the needle tip.

Procedure: Long-Axis In-Plane Ultrasound-Guided Cannulation

Interventions

Short-Axis Out-of-Plane Ultrasound-Guided Cannulation PROCEDURE

The ultrasound probe was positioned perpendicular to the target vein to obtain a transverse image. A peripheral intravenous cannula was inserted by advancing the needle using the out-of-plane technique under real-time ultrasound guidance.

Short-Axis Out-of-Plane Approach

Long-Axis In-Plane Ultrasound-Guided Cannulation PROCEDURE

The ultrasound probe was positioned parallel to the target vein to obtain a longitudinal image. A peripheral intravenous cannula was inserted by advancing the needle in plane while maintaining visualization of the needle tip under real-time ultrasound guidance.

Long-Axis In-Plane Approach

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Men and women aged 20 to 60 years
• Required peripheral intravenous access

You may not qualify if:

• Body mass index of 30 kg/m² or greater
• Infection at the intended cannulation site
• Upper-limb deformity
• Previous venous thrombosis
• Refusal to participate

Sponsors & Collaborators

• Lady Reading Hospital, Pakistan: lead

Study Sites (1)

Medical Teaching Institution-Lady Reading Hospital

Peshawar, Khyber Pakhtunkhwa, Pakistan

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PGR

Model Details: Participants were randomly assigned in a 1:1 ratio to one of two parallel groups. One group received ultrasound-guided peripheral intravenous cannulation using the short-axis out-of-plane approach, while the other received the long-axis in-plane approach. Each group included 111 participants.

Study Record Dates

• First Submitted: June 28, 2026
• First Posted: July 6, 2026
• Study Start: November 7, 2023
• Primary Completion: May 7, 2024
• Study Completion: May 7, 2024
• Last Updated: July 6, 2026

Record last verified: 2026-06

Locations

PA (1)