Exposome, Pollutants, Biology in the Older Subject: EXPOSAGE

NCT07678528 | Not Yet Recruiting

• 1 other identifier: 25-PP-25
• Study Type: interventional
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

Numerous factors, both individual and environmental, can influence aging, an individual's health, and their functional status. However, the understanding of the combined impact of lifestyle-related exposures (e.g., physical activity, diet, sleep) (personal external exposome), exposures to pollutants (environmental external exposome), and their biological responses (internal exposome)-in other words, the impact of the "exposome" on healthy aging-remains limited, particularly in characterizing the molecular mechanisms associated with these interactions. Exposome approaches identifying key exposures and molecular mechanisms could lead to a better understanding of how the environment, interacting with health behaviors, can affect functional status. Thus, the objective of this study is i) to evaluate the links between the external exposome, the internal exposome and the health of older and aging individuals, and ii) to identify biological markers associated with a vulnerable health status in older and aging individuals.

Conditions

Aging Disorder

Outcome Measures

Primary Outcomes (1)

• Frailty (health measure)

  Frailty is assessed using the Groningen Frailty Indicator. The scale comprises 15 items. The total score ranges from 0 to 25, with a higher score being worse.

  at baseline and 12 months later

Secondary Outcomes (16)

• Functional and health status

  at baseline and 1 year

• Physical functional capacities (health measure)

  at baseline and at 12 months

• Quality of life (health measure)

  at baseline and 12 months

• Autonomy (health measure)

  at baseline and 12 months

• Comorbidity (health measure)

  at baseline and 12 months

Study Arms (1)

Exposome assessment

OTHER

Other: Exposome assessment

Interventions

Exposome assessment OTHER

Visit 1: blood sample, questionnaires on the personal exposome (lifestyle habits (e.g., physical activity, diet, stress) and social characteristics and health status) \| ii) Outpatient assessment: wearing a silicone bracelet for 7 days to measure external environmental exposure to pollutants and quantify physical activity \| iii) Visit 2: 1-year follow-up of health status

Exposome assessment

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged 55 or over
• Affiliated with or beneficiaries of a social security scheme
• Signed the informed consent form •-Persons residing in one of the following municipalities : Antibes, Le Bar-sur-Loup, Berre-les-Alpes, Beuil, Blausasc, Breil-sur-Roya, Cabris, Cannes, Carros, Clans, Contes, Drap, L'Escarène, Escragnolles, Fontan, La Gaude, Gilette, Grasse, Lantosque, Levens, Nice, Peillon, Peymeinade, Saint-André-de-la-Roche, Saint-Etienne-de-Tinée, Sospel, Tourrettes-sur-Loup, Vence, Tende

You may not qualify if:

• patients currently undergoing intensive drug treatment, including chemotherapy

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nice: lead

Study Sites (1)

CHU de Nice - Hopital de Cimiez

Nice, France

Location

Central Study Contacts

Olivier GUERIN, PROFESSOR

CONTACT

0492034194; guerin.o@chu-nice.fr

Virginie PIOVANO

CONTACT

piovano.v@chu-nice.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 11, 2026
• First Posted: July 1, 2026
• Study Start (Estimated): September 1, 2030
• Primary Completion (Estimated): September 1, 2031
• Study Completion (Estimated): September 1, 2031
• Last Updated: July 1, 2026

Record last verified: 2026-06

Locations

FR (1)