NCT03848897

Brief Summary

The process of ageing affects at the same time the sensory, cognitive and driving functions. Furthermore, ageing is often accompanied by pathologies increasing the effects of the senescence. An ageing subject will have then more difficulties in maintaining balance control and will have a falling risk with sometimes critical consequences for the quality of life. The risk of fall is estimated by tests at the same time of current life and with scores of sensitivity and specificity which must be improved. In a review including 25 studies (2 314 subjects), show a sensitivity of 32 % and a specificity of 73 % on the test "Timed Up and Go" (TUG) with a threshold at 13.5 seconds. In addition, the fall occurs in a multifactorial context when a subject interacts with his environment. It therefore seems essential to test balance control or falling risk of individuals as close as possible to the situations of daily life. This research, based on the TUG, will aim to assess the neuro-psycho-motor behavior of subjects in situations close to daily life using a Virtual Reality (VR) and Human Metrology platform. The results could ultimately lead to increased sensitivity and specificity in assessing the risk of falling with a TUG performed in VR, compared to the classic TUG, which is commonly used by healthcare professionals and thus allow for earlier or more appropriate management of the subject in preventing the risk of falling. This could allow healthcare professionals to better understand the risk of falling and thus guide medical recommendations and prescribing, particularly in terms of appropriate physical activity programs.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
116

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Apr 2019

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 30, 2019

Completed
22 days until next milestone

First Posted

Study publicly available on registry

February 21, 2019

Completed
2 months until next milestone

Study Start

First participant enrolled

April 30, 2019

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2020

Completed
2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2022

Completed
Last Updated

April 16, 2019

Status Verified

April 1, 2019

Enrollment Period

1.2 years

First QC Date

January 30, 2019

Last Update Submit

April 12, 2019

Conditions

Keywords

Virtual realityHuman metrologyMotor behaviorModelingAgeingParkinson's disease

Outcome Measures

Primary Outcomes (1)

  • Timed Up & Go in virtual reality (VR)

    Time

    Baseline

Secondary Outcomes (13)

  • Timed Up & Go (non VR condition)

    Baseline

  • Validation of the TUG in VR condition

    1 year follow-up

  • Correlation between TUG and TUG VR times and fall follow-up

    1 year follow-up

  • Kinematics analysis

    Baseline

  • Kinetics analysis

    Baseline

  • +8 more secondary outcomes

Study Arms (3)

Non falling elderly

EXPERIMENTAL
Other: Metrology of motor behavior

Falling elderly

EXPERIMENTAL
Other: Metrology of motor behavior

Non falling patients with Parkinson's disease

EXPERIMENTAL
Other: Metrology of motor behavior

Interventions

Biomechanical, physiological, psychological and behavioral analyses

Falling elderlyNon falling elderlyNon falling patients with Parkinson's disease

Eligibility Criteria

Age65 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsOlder Adult (65+)

You may qualify if:

  • Non-faller elderly
  • Male and female
  • Age between 65 and 80 years old
  • Autonomous
  • Reporting no fall in the last 12 months
  • Fallers elderly
  • Male and female
  • Age between 65 and 80 years old
  • Autonomous
  • Reporting at least 1 fall in the last 12 months
  • Non-faller Patients with Parkinson's disease
  • Male and female
  • Age between 65 and 80 years old
  • Autonomous
  • Reporting no fall in the last 12 months
  • +2 more criteria

You may not qualify if:

  • Hearing loss preventing understanding of the instructions and listening to the sound message
  • Visual acuity not compatible with the test procedure in virtual reality
  • Inability to move without assistance
  • Not understanding written and oral French, illiteracy, dementia
  • Treatment including psychotropic drugs
  • Person in emergency situation,
  • Major person subject to a legal protection measure (guardianship, curator, safeguard of justice),
  • Major person unable to express his consent,
  • Hospitalized person,
  • Person deprived of liberty by a judicial or administrative decision, the persons being the object of psychiatric care by virtue of articles L. 3212-1 and L. 3213-1 of the french Code of Public Health,
  • Person likely, in the opinion of the investigator, not to be cooperating or respectful of the obligations inherent to participation in the study
  • Person with a predisposition to epilepsy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital of Nancy

Vandœuvre-lès-Nancy, 54500, France

Location

MeSH Terms

Conditions

Parkinson DiseaseMotor Activity

Condition Hierarchy (Ancestors)

Parkinsonian DisordersBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative DiseasesBehavior

Central Study Contacts

Philippe Perrin, MD PhD Prof

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 30, 2019

First Posted

February 21, 2019

Study Start

April 30, 2019

Primary Completion

June 30, 2020

Study Completion

June 30, 2022

Last Updated

April 16, 2019

Record last verified: 2019-04

Data Sharing

IPD Sharing
Will not share

Locations