NCT07674914

Brief Summary

The goal of this study is to develop and test the impact of a smartphone-based working memory cognitive training digital therapeutic for individuals with schizophrenia or a related disorder.

Trial Health

63
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
45

participants targeted

Target at P50-P75 for phase_1

Timeline
23mo left

Started Sep 2026

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 23, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

June 30, 2026

Completed
2 months until next milestone

Study Start

First participant enrolled

September 1, 2026

Expected
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2027

8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2028

Last Updated

June 30, 2026

Status Verified

June 1, 2026

Enrollment Period

1.2 years

First QC Date

June 23, 2026

Last Update Submit

June 23, 2026

Conditions

Schizophrenia / Schizoaffective Disorder

Keywords

schizophreniapsychosis

Outcome Measures

Primary Outcomes (1)

  • Change in number correct in letter number span working memory test

    Full scale of 24 items

    Day 1 and Day 16

Study Arms (1)

cognitive intervention

EXPERIMENTAL
Behavioral: Cognitive TrainingBehavioral: Mobile cognitive training

Interventions

Cognitive TrainingBEHAVIORAL

This will be a digital cognitive training program.

cognitive intervention
Mobile cognitive trainingBEHAVIORAL

This will be a remotely delivered mobile cognitive intervention via a smartphone application.

cognitive intervention

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • diagnosis of schizophrenia, schizoaffective disorder, or a related psychotic disorder
  • own a smartphone
  • English speaking
  • experiencing challenges with cognitive functioning
  • no changes to antipsychotic medication in past month

You may not qualify if:

  • history of neurological disorder
  • traumatic brain injury with loss of consciousness \> 10 minutes or behavioral sequelae.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States

Location

MeSH Terms

Conditions

SchizophreniaPsychotic Disorders

Interventions

Cognitive Training

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic DisordersMental Disorders

Intervention Hierarchy (Ancestors)

Neurological RehabilitationRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsHealth ServicesHealth Care Facilities Workforce and Services

Central Study Contacts

Lauren Luther, PhD

CONTACT

205-530-1117CAS-treatlab@uab.edu

Study Design

Study Type
interventional
Phase
phase 1
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

June 23, 2026

First Posted

June 30, 2026

Study Start (Estimated)

September 1, 2026

Primary Completion (Estimated)

December 1, 2027

Study Completion (Estimated)

August 1, 2028

Last Updated

June 30, 2026

Record last verified: 2026-06

Data Sharing

IPD Sharing
Will share

Locations

US(1)