Perioperative Antibiotic Exposure and Postoperative Delirium in Older Adults Undergoing Elective Non-cardiac Surgery: A Single-center Prospective Cohort Study

NCT07673510 | Completed DMC

• 1 other identifier: ChinaPLAGH_Antibiotic
• Study Type: observational
• Target: 4,711
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to characterize the current patterns of perioperative prophylactic antibiotic use and to systematically evaluate the association between different antibiotic classes and the occurrence of POD, thereby providing clinically relevant safety evidence for perioperative antibiotic decision-making and delirium prevention strategies.

Conditions

Delirium - Postoperative

Outcome Measures

Primary Outcomes (1)

• Incidence of postoperative delirium

  Evaluations are conducted twice a day.

  Participants will be followed for the duration of hospital stay, an expected average of 7 days.

Study Arms (1)

Antibiotic

Drug: Perioperative antibiotics exposure

Interventions

Perioperative antibiotics exposure DRUG

Antimicrobial exposure was defined as a record of antibiotic use prior to the occurrence of delirium. Antimicrobials were divided into five non-mutually exclusive groups: beta-lactams (subclasses: first- through fourth-generation cephalosporins, penicillins and carbapenems), nitroimidazoles, glycopeptides, fluoroquinolones, and others (subclasses: aminoglycosides, oxazolidinones, antifungals, lincosamides, macrolides, and fosfomycins).

Antibiotic

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study included older adult patients (aged 65 years) scheduled for elective non-cardiac surgery in the First Medicine Department of the Chinese PLA General Hospital between April 2020 and April 2022, from whom complete medication records were obtained.

You may qualify if:

• patients over 65 years old
• patients undergoing elective non-cardiac surgery

You may not qualify if:

• older adult patients who had history of psychotic disorders
• history of neurological disease
• conditions that would make assessments for delirium unreliable
• preoperative infection
• severe hepatic and renal dysfunction, minor and intermediate clean-incision surgery
• missing data exceeding 5%, and no medication records

Sponsors & Collaborators

• Chinese PLA General Hospital: lead

Study Sites (1)

Chinese PLA General Hospital, Beijing

Beijing, China

Location

MeSH Terms

Conditions

Emergence Delirium

Condition Hierarchy (Ancestors)

Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Study Officials

• Hao Li

  Chinese PLA General Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Study Record Dates

• First Submitted: June 23, 2026
• First Posted: June 29, 2026
• Study Start: April 1, 2020
• Primary Completion: April 1, 2022
• Study Completion: May 1, 2026
• Last Updated: June 29, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)