A Clinical Trial to Evaluate the Effects of a Plant-Based Liquid Supplement on Metabolic Health and Overall Well-Being

NCT07673432 | Completed

• 1 other identifier: #20758
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This single-arm clinical trial will evaluate the effects of a plant-based liquid supplement on metabolic health, digestive health, skin health, and overall well-being. Twenty participants aged 40 to 60 years with elevated alanine transaminase (ALT) or aspartate transaminase (AST) levels will use the supplement daily for 90 days. Participants will complete questionnaires, provide body composition and waist circumference measurements, submit photographs, and undergo blood testing throughout the study. Outcomes include changes in metabolic biomarkers, body composition, digestive symptoms, skin health, and overall well-being.

Conditions

Metabolic Health; Elevated Liver Enzymes; Digestive Symptoms

Outcome Measures

Primary Outcomes (10)

• Change in Body Weight

  Change in body weight measured using a Withings smart scale.

  Baseline, Day 30, Day 60, and Day 90.

• Change in Waist Circumference

  Change in waist circumference measured using a tape measure and recorded in centimeters.

  Baseline, Day 7, Day 30, Day 60, and Day 90.

• Change in Body Fat Mass

  Change in body fat mass measured using a Withings smart scale.

  Baseline, Day 7, Day 30, Day 60, and Day 90.

• Change in Lean Body Mass

  Change in lean body mass measured using a Withings smart scale.

  Baseline, Day 7, Day 30, Day 60, and Day 90.

• Change in Visceral Fat Index

  Change in visceral fat index measured using a Withings smart scale.

  Baseline, Day 7, Day 30, Day 60, and Day 90.

• Change in Alanine Aminotransferase (ALT)

  Change in serum alanine aminotransferase concentration measured by hepatic function panel.

  Baseline, Day 30, Day 60, and Day 90.

• Change in Aspartate Aminotransferase (AST)

  Change in serum aspartate aminotransferase concentration measured by hepatic function panel.

  Baseline, Day 30, Day 60, and Day 90

• Change in Alkaline Phosphatase (ALP)

  Change in serum alkaline phosphatase concentration measured by hepatic function panel.

  Baseline, Day 30, Day 60, and Day 90.

• Change in Total Bilirubin

  Change in serum total bilirubin concentration measured by hepatic function panel.

  Baseline, Day 30, Day 60, and Day 90.

• Change in Total Cholesterol

  Change in serum total cholesterol concentration measured by lipid panel.

  Baseline, Day 30, Day 60, and Day 90.

Secondary Outcomes (5)

• Change in Participant-Reported Bloating Severity

  Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.

• Change in Participant-Reported Flatulence Severity

  Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.

• Change in Participant-Reported Heartburn Severity

  Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.

• Change in Participant-Reported Digestive Comfort

  Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.

• Change in Participant-Reported Skin Health

  Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.

Study Arms (1)

Plant-Based Liquid Supplement

EXPERIMENTAL

Participants will consume one ampule of the study product diluted in approximately 8 ounces of water before the first meal of the day throughout the study period.

Dietary Supplement: Plant-Based Liquid Supplement

Interventions

Plant-Based Liquid Supplement DIETARY_SUPPLEMENT

A liquid dietary supplement containing choline bitartrate, zinc sulfate, manganese sulfate, artichoke leaf extract, fennel extract, rosemary leaf extract, L-arginine monohydrochloride, inositol, bromelain, papain, sorbitol, glycerin, artificial flavour, and potassium sorbate.

Plant-Based Liquid Supplement

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age 40 to 60 years
• Elevated ALT or AST identified during prescreening blood testing
• Currently experiencing at least two of the following:
• Stomach discomfort, Constipation, Diarrhea, Heartburn, Bloating, Gas, Abdominal pain, Skin redness or pimples, Sugar cravings
• Willing to comply with study requirements
• Willing to discontinue supplements or herbal remedies targeting detoxification, digestive health, liver function, or skin health during the study
• Willing to avoid starting new products, medications, or supplements targeting detoxification, digestive health, liver function, or skin health
• Willing to maintain normal diet, sleep patterns, and activity levels
• Generally healthy without uncontrolled chronic disease
• Resides in the United States
• Not participating in another research study during the study period
• Has access to a study partner to take study photographs

You may not qualify if:

• Severe digestive disorders including acid reflux, IBS, IBD, Crohn's disease, or gastrointestinal tract surgeries
• Liver disease
• Known allergy or hypersensitivity to study product ingredients Chronic conditions that would interfere with study participation, including oncological or psychiatric disorders
• Known severe allergic reactions
• Pregnant, breastfeeding, or attempting to conceive
• Unwilling to follow study procedures
• Stopped hormonal birth control within the past month
• History of substance abuse
• Use of prescription diabetes medications, including GLP-1 receptor agonists such as Ozempic, Wegovy, or Mounjaro

Sponsors & Collaborators

• Biocol Labs: lead
• Citruslabs: collaborator

Study Sites (1)

Citruslabs

Las Vegas, Nevada, 89118, United States

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 23, 2026
• First Posted: June 29, 2026
• Study Start: June 5, 2025
• Primary Completion: January 15, 2026
• Study Completion: January 15, 2026
• Last Updated: June 29, 2026

Record last verified: 2026-06

Locations

US (1)