Khoury's Bone Shell Technique Versus Titanium-Reinforced Polytetrafluoroethylene for Augmentation of Horizontal Deficiency in Posterior Mandible (Histomorphometry Analysis)

NCT07669792 | Recruiting DMC

• 1 other identifier: 25-018
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the study is the comparison of bone gained histologically from the Bone Shell Khoury's Technique in comparison with the usage of non-resorbable membrane polytetrafluoroethylene and discussing its eligibility for implant placement in restoring the atrophic posterior mandible.

Conditions

Alveolar Bone Loss; Posterior Mandible

Outcome Measures

Primary Outcomes (1)

• Histomorphometric analysis of gained bone

  Primary evaluation is achieved through re opening of the flap after 6 months for removing the microscrews used in Khoury group and the nonresorbable membrane as well as the screws will be removed from the nonresorbable membrane group. Then the usage of 2 millimeters bur for core biopsy at the site of the implant that will be placed.

  6 Months

Study Arms (2)

GBR using Ti based PTFE

EXPERIMENTAL

This group will receive a non resorbable membrane using titanium reinforced polytetrafluorethylene membrane.

Procedure: GBR using Ti based PTFE

Bone Shell Khoury's Technique

ACTIVE COMPARATOR

This group will receive a block graft using Khoury Technique.

Procedure: Bone Shell Khoury's Technique

Interventions

GBR using Ti based PTFE PROCEDURE

Patients will receive a non resorbable membrane using titanium reinforced polytetrafluorethylene membrane with full releasing flap buccal and lingual with the lingual dissection for the releasing of the mylohyoid attachment and nerve dissection of the mental nerve buccally. The membrane needs to be fixed lingually with microscrews or titanium screws then the gap will be filled through Auto Chip Maker ACM or bone scraper from the external oblique ridge. Then the harvested bone shall be mixed xenograft with ratio 70 to 30 then the membrane fixed buccally as well as covered by collagen membrane to avoid one of the main obstacles of the procedure which is wound dehiscence.

GBR using Ti based PTFE

Bone Shell Khoury's Technique PROCEDURE

A block graft using Khoury Technique: Prior to harvesting the needed bone, measurement of the defect size as well as measurement of the donor site bone block will be harvested from the mandibular retromolar area. The bone shall be acquired through piezoelectric device that perform the osteotomy then separated through the usage of thin chisel. The acquired bone needs to be smoothened to avoid any sharp edge that may cause wound dehiscence or infection. The harvested bone will be divided into two thinner bone shells through using titanium disk with copious irrigation with saline. The bone shell shall be fixated in the defect site buccally through two microscrews at least then the created space shall be filled with a combination of autogenous bones harvested through Auto Chip Maker (ACM) or bone scraper from the external oblique ridge. The harvested bone will be combined with xenograft with ratio 70 to 30 then the defect shall be covered with collagen membrane.

Bone Shell Khoury's Technique

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Have two or more missing teeth in the posterior mandibular segment.
• The patients age of 18 and above.
• The alveolar ridge in the edentulous site of the selected patients will have a buccolingual width of less than 4mm.
• Sufficient vertical bone height.
• Free of any local or systemic condition that may contraindicate ridge expansion procedure.

You may not qualify if:

• Patients taking any medication that may interfere with bone healing or bone biology.
• Patients with any systemic disease that may affect bone healing.
• Any patients with any previous bone grafting procedure at the site of interest.
• Smokers.
• Patient's that have been diagnosed with periodontal disease, as sufficient ridge height would be improbable.
• Patients with significant vitamin D deficiency.

Sponsors & Collaborators

• British University In Egypt: lead

Study Sites (1)

The British University in Egypt

Cairo, Egypt

RECRUITING

MeSH Terms

Conditions

Alveolar Bone Loss

Condition Hierarchy (Ancestors)

Bone Resorption; Bone Diseases; Musculoskeletal Diseases; Periodontal Atrophy; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Central Study Contacts

Abdelaziz H. Saad Abdelkarim, Bachelor's Degree

CONTACT

+201020690459; PG.Abdelaziz92344012@bue.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Master's Candidate

Study Record Dates

• First Submitted: June 21, 2026
• First Posted: June 25, 2026
• Study Start: June 20, 2025
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): March 1, 2027
• Last Updated: July 16, 2026

Record last verified: 2026-07

Locations

EG (1)