Pulse Wave Transit Time After Infraclavicular Block

NCT07669688 | Not Yet Recruiting

• 1 other identifier: SAU-ANE-BA-04
• Study Type: observational
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to evaluate the time-dependent changes in Pulse Wave Transit Time (PWTT) following ultrasound-guided infraclavicular brachial plexus block. PWTT is a non-invasive hemodynamic parameter reflecting vascular tone and sympathetic nervous system activity. Patients undergoing upper extremity surgery under infraclavicular block will be monitored using standard perioperative monitoring devices. PWTT measurements will be obtained before and after block placement at predefined time intervals. Secondary outcomes will include perfusion index, skin temperature, heart rate, blood pressure, respiratory rate, and oxygen saturation. The study seeks to determine whether PWTT can serve as an objective and non-invasive marker of sympathetic blockade following infraclavicular block.

Conditions

Infraclavicular Brachial Plexus Block

Keywords

Infraclavicular Block; Pulse Wave Transit Time; Regional Anesthesia; Brachial Plexus Block; Sympathetic Blockade

Outcome Measures

Primary Outcomes (1)

• Change in Pulse Wave Transit Time

  The primary outcome is the time-dependent change in Pulse Wave Transit Time (PWTT) following ultrasound-guided infraclavicular brachial plexus block. PWTT will be measured as the interval between the R-wave of the electrocardiogram (ECG) and the corresponding pulse wave detected by peripheral pulse oximetry. Measurements will be recorded at baseline (pre-block) and at 0, 5, 10, 15, and 20 minutes after block placement. The primary analysis will evaluate the change in PWTT over time within the blocked extremity.

  20 minutes after infraclavicular block

Secondary Outcomes (3)

• Perfusion Index

  20 minutes after infraclavicular block

• Skin Temperature

  20 minutes after infraclavicular block

• oxygen saturation

  20 minutes after infraclavicular block

Study Arms (1)

Infraclavicular Block Group

Patients undergoing routine ultrasound-guided infraclavicular brachial plexus block for upper extremity surgery will be included in this observational cohort. Pulse Wave Transit Time (PWTT) and other hemodynamic parameters will be measured at predefined time points before and after block administration. No additional intervention beyond standard clinical care will be performed for research purposes.

Procedure: Ultrasound-guided infraclavicular brachial plexus block

Interventions

Ultrasound-guided infraclavicular brachial plexus block PROCEDURE

Ultrasound-guided infraclavicular brachial plexus block will be performed as part of routine clinical anesthesia practice for upper extremity surgery. Local anesthetic will be administered according to standard institutional protocols. No additional or experimental drug or procedure will be applied for research purposes. Pulse Wave Transit Time (PWTT) and other hemodynamic parameters will be recorded before and after block placement at predefined time intervals.

Infraclavicular Block Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of adult patients aged 18-65 years with ASA physical status I who are scheduled to undergo elective upper extremity hand surgery under ultrasound-guided infraclavicular brachial plexus block. All participants will receive standard-of-care anesthesia management. Patients with contraindications to peripheral nerve block, significant systemic disease, obesity (BMI ≥30 kg/m²), coagulation disorders, opioid use, or conditions affecting sympathetic activity will be excluded. Only patients who provide informed consent will be enrolled.

You may qualify if:

• Patients undergoing elective upper extremity hand surgery
• years
• ASA I
• No coagulopathy, thrombocytopenia, coagulation disorders
• Patients who provide informed consent to participate in the study

You may not qualify if:

• History of drug allergy relevant to study procedures or local anesthetics
• Body mass index (BMI) ≥ 30 kg/m²
• Body weight \< 40 kg
• Age \< 18 years or \> 65 years
• History of significant cardiac disease (e.g., arrhythmia, conduction abnormalities)
• Coagulopathy (INR \> 1.5 or platelet count \< 100,000/mm³)
• Pregnancy or lactation
• Infection at the site of peripheral nerve block
• ASA II-IV
• Failed block or motor block duration exceeding 30 minutes
• Patients reporting pain (NRS ≥ 3), due to potential influence on sympathetic activity
• Chronic opioid use

Sponsors & Collaborators

• Sakarya University: lead

Study Sites (1)

Sakarya University-Anesthesiology and Reanimation Department

Sakarya, Turkey (Türkiye)

Location

Related Publications (1)

• Choi EJ, Lim JA, Choi CH, Kim DH, Jo S, Kim J. Changes in pulse wave transit time variability after interscalene brachial plexus block placement. Korean J Anesthesiol. 2026 Feb;79(1):82-94. doi: 10.4097/kja.24861. Epub 2025 May 21.

  PMID: 40398868 RESULT

Central Study Contacts

Burçin Alaçam

CONTACT

+905465903851; burcin.ersoy90@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: June 20, 2026
• First Posted: June 25, 2026
• Study Start: July 20, 2026
• Primary Completion (Estimated): October 15, 2026
• Study Completion (Estimated): November 15, 2026
• Last Updated: July 7, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)