Health Ahead Comparative Effectiveness Study
HACE
Health Ahead: Sequential Comparative-Effectiveness Studies Toward Automated, Universally Deployable Preventive Health Screening
2 other identifiers
interventional
1,000,000
1 country
1
Brief Summary
The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening - each isolated as a single variable against current practice - on the path toward a fully automated screening system deployable in any environment, including the most isolated and resource-limited communities. Each comparison is evaluated with a common set of engagement, behavior-change, experience, cost, and longitudinal outcome measures, allowing results to accumulate on a consistent yardstick across the life of the platform. The first comparison evaluates static versus interactive personalized health report delivery. Subsequent pre-planned comparisons, added by protocol amendment, evaluate mobile community versus fixed laboratory screening; and a hybrid medical-droid plus human-delivery model versus human-only screening. All participants are simultaneously enrolled in the 100-Year Human Aging Study and the Human Observatory Study, contributing individual longitudinal and population-level causal inference data through those protocols.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jun 2026
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 9, 2026
CompletedStudy Start
First participant enrolled
June 9, 2026
CompletedFirst Posted
Study publicly available on registry
June 25, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2099
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2099
June 25, 2026
June 1, 2026
73.6 years
June 9, 2026
June 20, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Health Activation and Engagement (Non-Inferiority)
Change from baseline in health activation score, measured by a validated open-source instrument, compared between the static report arm (Arm A) and the interactive report arm (Arm B). Non-inferiority of the interactive arm is assessed with a one-sided non-inferiority test against a non-inferiority margin pre-specified in the comparison's Statistical Analysis Plan and locked before any analysis of comparison data.
Baseline, 6-12-month follow-up, then periodically from enrollment until death, up to 100 years.
Secondary Outcomes (23)
Health Activation and Engagement (Superiority)
Baseline, 6-12-month follow-up, then periodically from enrollment until death, up to 100 years.
Report Efficacy and Utilization
Baseline, 6-12-month follow-up, then periodically from enrollment until death, up to 100 years.
Unintended Consequences and Psychological Impact
Baseline, 6-12-month follow-up, then periodically from enrollment until death, up to 100 years.
Completion of Provider-Recommended Health Behavior Changes
Baseline, 6-12-month follow-up, then periodically from enrollment until death, up to 100 years.
Primary Barrier to Non-Completion of Recommended Changes
Baseline, 6-12-month follow-up, then periodically from enrollment until death, up to 100 years.
- +18 more secondary outcomes
Study Arms (6)
Static Personalized Health Report
ACTIVE COMPARATORParticipants complete comprehensive multi-system health screening and receive a standard static personalized health report.
Interactive Personalized Health Report
EXPERIMENTALParticipants complete identical comprehensive multi-system health screening and receive an interactive personalized report allowing real-time adjustment of behaviors and diagnostic inputs to visualize projected changes in composite scores, estimated biological age, and aging trajectory.
Fixed-Lab Health Screenings
ACTIVE COMPARATORHealth screenings performed at fixed-lab site.
Mobile Lab Health Screenings
EXPERIMENTALHealth screenings performed in remote locations using a mobile lab
Human Delivered Health Screenings
ACTIVE COMPARATORHealth screenings delivered by human operators only
Hybrid Medical Droid and Human Delivered Health Screenings
EXPERIMENTALHealth screenings delivered by a hybrid model using medical droid and human operators
Interventions
Static versus interactive health report
Mobile versus Fixed Laboratory Health Screenings
Hybrid Medical Droid and Human Delivered versus Human-Only Delivered Health Screenings
Eligibility Criteria
You may qualify if:
- Age 18 years or older
- Willing and able to provide written informed consent, or enrollment with consent of a legally authorized representative
- Willing to participate in longitudinal follow-up.
You may not qualify if:
- \- Age under 18 years.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Longevity Metrics
Boulder, Colorado, 80301, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
William Brandenburg, MD
Longevity Metrics
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- HEALTH SERVICES RESEARCH
- Intervention Model
- FACTORIAL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
June 9, 2026
First Posted
June 25, 2026
Study Start
June 9, 2026
Primary Completion (Estimated)
December 31, 2099
Study Completion (Estimated)
December 31, 2099
Last Updated
June 25, 2026
Record last verified: 2026-06
Data Sharing
- IPD Sharing
- Will not share