Empowering Veterans in Research Effectively Using Virtual Engagement Tools
EVERYVET
EVERYVET (Empowering VEterans in Research effectivelY Using Virtual Engagement Tools): A Patient-Centered Study
2 other identifiers
interventional
100,000
1 country
1
Brief Summary
Cardiovascular disease is the leading cause of death among Veterans. Clinical trials are essential for developing better treatments, but Veterans remain underrepresented in these studies due to barriers including limited health literacy, lack of awareness, and mistrust. Current outreach approaches rely on either in-person physician conversations, which are limited by workforce constraints, or mailed letter invitations, which often fail to engage Veterans with limited health literacy. This study tests whether AI-generated video avatars can improve Veteran engagement in cardiovascular clinical trials.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Oct 2026
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 13, 2026
CompletedFirst Posted
Study publicly available on registry
August 3, 2026
CompletedStudy Start
First participant enrolled
October 1, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2030
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2031
September 3, 2026
August 1, 2026
4.3 years
July 13, 2026
August 31, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Proportion of Veterans who enroll in the parent VA Cooperative Studies cardiovascular trial within 6 months of receiving the invitation
Superiority of enrollment rate in the intervention arm (AI-supported avatar invitation) compared to the control arm (routine letter invitation alone), assessed using an intention-to-treat approach.
Baseline through 6 months
Secondary Outcomes (3)
Proportion of Veterans accessing the intervention website
Baseline through 6 months
Proportion of Veterans viewing avatar videos
Baseline through 6 months
Avatar preferences
Baseline through 6 months
Study Arms (2)
Control: Standard Mailed Letter Invitation
NO INTERVENTIONVeterans randomized to the control arm receive the standard mailed letter invitation to the parent VA Cooperative Studies cardiovascular trial, which represents current standard of care for large-scale VA cardiovascular trial outreach.
Experimental: AI-Supported Virtual Outreach
EXPERIMENTALVeterans randomized to the intervention arm receive the standard mailed letter invitation enhanced with a QR code and URL linking to a website hosting AI-generated avatar videos. Veterans may select their preferred avatar speaker from a diverse set of options and self-select content topics of interest. QR codes are deployed for both the screening and treatment components of the parent cardiovascular trial.
Interventions
Veterans randomized to the intervention arm will receive the website link where they can select their preferred avatar speaker(s) from a diverse set of options and self-select content topics of interest. They may watch the self-directed tailored video to guide their decision to participate in the parent trial.
Eligibility Criteria
You may qualify if:
- Veteran receiving care at VAPAHCS
- Recently invited (within 3 months) to participate in an existing cardiovascular clinical trial at VAPAHCS
- Able to provide informed consent in English
- Veteran receiving care at VAPAHCS or a participating VA-CTC site
- Able to view a brief video and complete a short survey in English
- VA study coordinator or trial investigator actively engaged in cardiovascular clinical trial recruitment at VAPAHCS or a VA-CTC site
- Willing to participate in a 60-90 minute virtual focus group
You may not qualify if:
- Cognitive impairment documented in the electronic health record
- Inability to communicate in English at a level sufficient for qualitative interview participation
- Inability to communicate in English at a level sufficient for survey completion
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Stanford Universitycollaborator
- Palo Alto Veterans Institute for Researchcollaborator
- VA Office of Research and Developmentlead
Study Sites (1)
VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, 94304-1207, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Celina M. Yong, MD MBA MSc
VA Palo Alto Health Care System, Palo Alto, CA
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Masking Details
- Participants in the control arm receive a standard mailed letter and are not aware of the avatar video intervention being received by the intervention arm. Study coordinators and investigators are aware of group assignment for operational purposes. Full blinding is not possible given the nature of the communication intervention.
- Purpose
- HEALTH SERVICES RESEARCH
- Intervention Model
- PARALLEL
- Sponsor Type
- FED
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 13, 2026
First Posted
August 3, 2026
Study Start
October 1, 2026
Primary Completion (Estimated)
December 31, 2030
Study Completion (Estimated)
December 31, 2031
Last Updated
September 3, 2026
Record last verified: 2026-08
Data Sharing
- IPD Sharing
- Will not share
Individual participant data will not be shared externally. De-identified aggregate data will be disseminated through peer-reviewed publication and presentation at national cardiovascular conferences.