Pathological Mechanism Study of Aerobic Exercise Regulating Cold Stress-induced Hypertension Via the Thermosensitive Target-mediated Sympathetic Nerve Pathway

NCT07666607 | Completed DMC

• 1 other identifier: Wjingfeng1103
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This study focuses on the specificity of thermosensitive targets in populations with hypertension in cold regions, identifies core targets through transcriptome sequencing and clinical validation, and clarifies the regulatory mechanism of moderate-intensity aerobic exercise through a prospective cohort study, providing scientific basis for precise prevention and treatment of hypertension in cold regions and personalized exercise intervention.

Conditions

Hypertension

Outcome Measures

Primary Outcomes (4)

• blood pressure (BP)

  Systolic blood pressure, unit: mmHg Diastolic blood pressure, unit: mmHg Mean arterial pressure, unit: mmHg

  December 28, 2025

• heart rate variability (HRV)

  Low Frequency，Unit: nu High Frequency ，Unit: nu Low Frequency / High Frequency ratio Root Mean Square of Successive Differences，Unit: ms Percentage of successive NN intervals differing by more than 50 ms，Unit: % Standard Deviation of all Normal-to-Normal RR intervals，Unit: ms

  28 December 2025

• markers of the sympathetic nervous system (SNS)

  Epinephrine, unit: ng/L Norepinephrine, unit: ng/L

  December 28, 2025

• mRNA expression of genes

  Unit: relative expression level

  December 28, 2025

Interventions

Exercise exposure BEHAVIORAL

Patients with essential hypertension in cold regions who met the inclusion criteria were prospectively recruited and divided into an exercise exposure group and a non-exercise control group based on their willingness to accept and adhere to the exercise protocol developed for this study, with a follow-up period of 16 weeks. At baseline and the end of follow-up, we measured the expression of core thermosensitive targets, blood pressure (BP), heart rate variability (HRV), as well as the levels of sympathetic neurotransmitters and indicators of the renin-angiotensin-aldosterone system (RAAS), and compared the changes in these indicators between the two groups.

Eligibility Criteria

• Age: 60 Years - 69 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Hypertensive population

Sponsors & Collaborators

• Wang Jingfeng: lead

Study Sites (1)

Harbin Sport University

Harbin, Heilongjiang, 150008, China

Location

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 16 Weeks
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Ph.D.

Study Record Dates

• First Submitted: June 13, 2026
• First Posted: June 24, 2026
• Study Start: October 4, 2024
• Primary Completion: December 28, 2025
• Study Completion: December 28, 2025
• Last Updated: June 24, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)