Effect of Marjoram, Vetiver, and Lavender Oil in the Treatment of Bruxism

NCT07665398 | Active Not Recruiting

• 1 other identifier: 2023/346
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to investigate the possible effects of the use of lavender, marjoram and vetiver oil via inhalation and/or massage application on the treatment of bruxism.

Conditions

Bruxism; Bruxism, Sleep; Bruxism, Sleep-Related

Keywords

bruxism; sleep bruxism; aromatherapy; lavender oil; marjoram oil; vetiver oil; essentials oil; masticatory muscle; masseter muscle; ultrasonography; myofascial pain

Outcome Measures

Primary Outcomes (2)

• Change in Masseter Muscle Elasticity

  Assessment of changes in masseter muscle elasticity using shear-wave elastography measured by ultrasonography.

  Baseline to Week 4

• Change in Masseter Muscle Thickness

  Assessment of changes in masseter muscle thickness measured by ultrasonography.

  Baseline to Week 4

Secondary Outcomes (2)

• Change in Bruxism-Related Symptoms

  Baseline to Week 4

• Patient Satisfaction With Treatment

  Week 4

Study Arms (2)

Aromatherapy Group

EXPERIMENTAL

Participants receive aromatherapy by inhalation twice daily and extraoral massage once daily throughout the study period. Outcomes are evaluated using ultrasonographic measurements and patient-reported questionnaires.

Other: Aromatherapy with Essential Oil Blend (Lavender, Marjoram, Vetiver)

Control Group

PLACEBO COMPARATOR

Participants receive carrier oil (sesame oil) administered through inhalation and extraoral massage following the same protocol as the intervention group. Outcomes are evaluated using ultrasonographic measurements and patient-reported questionnaires.

Other: Carrier Oil (Sesame Oil)

Interventions

Carrier Oil (Sesame Oil) OTHER

Participants receive carrier oil (sesame oil) administered through inhalation and extraoral massage according to the same protocol used in the intervention group.

Control Group

Aromatherapy with Essential Oil Blend (Lavender, Marjoram, Vetiver) OTHER

Participants receive aromatherapy using a proprietary essential oil blend (Lavender Lavandula angustifolia, Marjoram Origanum majorana, and Vetiver Vetiveria zizanioides; Art De Huile®, formulated by Hülya Kayhan). The blend is administered by inhalation twice daily and extraoral massage once daily throughout the study period.

Aromatherapy Group

Eligibility Criteria

• Age: 18 Years - 25 Years
• Gender Eligibility Details: Only female participants are eligible for this study, as the study population is restricted to women aged 18 to 25 years according to the study protocol.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients between 18-25
• Patients with full dentition including 2nd molars
• Patients without facial asymmetry
• Patients without history of sensitivity or allergy to plants
• Patients without olfactory disorders

You may not qualify if:

• Patients with systemic (asthma history) and/or neuromuscular disease
• Patients with orofacial pain not caused by bruxism
• Temporomandibular joint (TMJ) surgery or injection history
• Use of any medical drug affecting the muscular system
• Patients with developmental deformity or surgery history in the maxillofacial region (facial trauma history, resection history, etc.)
• TMJ pathologies (major condylar changes seen on panoramic radiograph)
• Radiotherapy and/or chemotherapy history
• Ongoing orthodontic treatment
• Removable prosthesis use
• Inflammatory connective tissue diseases
• Pregnancy
• Obstructive sleep apnea
• Local skin infection over the myofascial area
• Reluctance to take responsibility for the work

Sponsors & Collaborators

• Necmettin Erbakan University: lead
• Ankara University: collaborator
• Izmir Katip Celebi University: collaborator
• Bilecik Seyh Edebali Universitesi: collaborator

Study Sites (1)

Bilecik Seyh Edebali University

Bilecik, Merkez, 11100, Turkey (Türkiye)

Location

Related Publications (12)

• Seifert O, Baerwald C. [Stimulation of the vagus nerve as a therapeutic principle. German Version]. Z Rheumatol. 2023 Aug;82(6):462-471. doi: 10.1007/s00393-023-01390-x. Epub 2023 Jul 25. German.

  PMID: 37490129 BACKGROUND

• Bennett R. Myofascial pain syndromes and their evaluation. Best Pract Res Clin Rheumatol. 2007 Jun;21(3):427-45. doi: 10.1016/j.berh.2007.02.014.

  PMID: 17602992 BACKGROUND

• Palinkas M, De Luca Canto G, Rodrigues LA, Bataglion C, Siessere S, Semprini M, Regalo SC. Comparative Capabilities of Clinical Assessment, Diagnostic Criteria, and Polysomnography in Detecting Sleep Bruxism. J Clin Sleep Med. 2015 Nov 15;11(11):1319-25. doi: 10.5664/jcsm.5196.

  PMID: 26235152 BACKGROUND

• Johnson JR, Rivard RL, Griffin KH, Kolste AK, Joswiak D, Kinney ME, Dusek JA. The effectiveness of nurse-delivered aromatherapy in an acute care setting. Complement Ther Med. 2016 Apr;25:164-9. doi: 10.1016/j.ctim.2016.03.006. Epub 2016 Mar 7.

  PMID: 27062964 BACKGROUND

• Gok Metin Z, Arikan Donmez A, Izgu N, Ozdemir L, Arslan IE. Aromatherapy Massage for Neuropathic Pain and Quality of Life in Diabetic Patients. J Nurs Scholarsh. 2017 Jul;49(4):379-388. doi: 10.1111/jnu.12300. Epub 2017 Jun 12.

  PMID: 28605119 BACKGROUND

• Nasiri A, Mahmodi MA, Nobakht Z. Effect of aromatherapy massage with lavender essential oil on pain in patients with osteoarthritis of the knee: A randomized controlled clinical trial. Complement Ther Clin Pract. 2016 Nov;25:75-80. doi: 10.1016/j.ctcp.2016.08.002. Epub 2016 Aug 3.

  PMID: 27863613 BACKGROUND

• Medlicott MS, Harris SR. A systematic review of the effectiveness of exercise, manual therapy, electrotherapy, relaxation training, and biofeedback in the management of temporomandibular disorder. Phys Ther. 2006 Jul;86(7):955-73.

  PMID: 16813476 BACKGROUND

• Ariji Y, Nakayama M, Nishiyama W, Ogi N, Sakuma S, Katsumata A, Kurita K, Ariji E. Potential clinical application of masseter and temporal muscle massage treatment using an oral rehabilitation robot in temporomandibular disorder patients with myofascial pain. Cranio. 2015 Oct;33(4):256-62. doi: 10.1080/08869634.2015.1097303. Epub 2015 Dec 29.

  PMID: 26714800 BACKGROUND

• Capellini VK, de Souza GS, de Faria CR. Massage therapy in the management of myogenic TMD: a pilot study. J Appl Oral Sci. 2006 Jan;14(1):21-6. doi: 10.1590/s1678-77572006000100005.

  PMID: 19089025 BACKGROUND

• Pessoa DR, Costa DR, Prianti BM, Costa DR, Delpasso CA, Arisawa EALS, Nicolau RA. Association of facial massage, dry needling, and laser therapy in Temporomandibular Disorder: case report. Codas. 2018 Nov 29;30(6):e20170265. doi: 10.1590/2317-1782/20182017265.

  PMID: 30517267 BACKGROUND

• Armijo-Olivo S, Pitance L, Singh V, Neto F, Thie N, Michelotti A. Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis. Phys Ther. 2016 Jan;96(1):9-25. doi: 10.2522/ptj.20140548. Epub 2015 Aug 20.

  PMID: 26294683 BACKGROUND

• Fernandez-de-las-Penas C, Svensson P. Myofascial Temporomandibular Disorder. Curr Rheumatol Rev. 2016;12(1):40-54. doi: 10.2174/1573397112666151231110947.

  PMID: 26717949 BACKGROUND

Related Links

• Vetiver Oil and Its Sedative Effect

MeSH Terms

Conditions

Bruxism; Sleep Bruxism

Interventions

Aromatherapy; Carrier State; Sesame Oil

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases; Habits; Behavior; Parasomnias; Sleep Wake Disorders; Nervous System Diseases; Mental Disorders

Intervention Hierarchy (Ancestors)

Mind-Body Therapies; Complementary Therapies; Therapeutics; Phytotherapy; Sensory Art Therapies; Psychotherapy; Behavioral Disciplines and Activities; Epidemiologic Methods; Public Health; Environment and Public Health; Dietary Fats, Unsaturated; Dietary Fats; Fats; Lipids; Fats, Unsaturated; Plant Oils; Oils; Plant Preparations; Biological Products; Complex Mixtures; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Prof.

Model Details: Participants with bruxism are assigned to one of two parallel groups. The intervention group receives aromatherapy with lavender, marjoram, and vetiver essential oils administered through inhalation and massage, while the control group receives carrier oil with the same massage protocol. Outcomes are assessed at baseline and during follow-up using ultrasonographic measurements and patient-reported questionnaires.

Study Record Dates

• First Submitted: June 18, 2026
• First Posted: June 24, 2026
• Study Start: September 2, 2024
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): January 31, 2027
• Last Updated: July 2, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)