NCT07665008

Brief Summary

Muscle fatigue is a multifactorial physiological phenomenon characterized by a reduction in the ability of a muscle to generate force during sustained or repetitive contractions. This cross-sectional observational study aimed to investigate the relationships among muscle thickness, surface electromyography (sEMG) median frequency, accelerometer-derived mechanical vibration parameters, and isometric force characteristics in healthy male soccer players. Thirty participants aged 18-30 years underwent ultrasonographic muscle thickness assessment, synchronized sEMG and accelerometer recordings, and isometric strength testing at different knee flexion angles (90°, 60°, and 30°). The study evaluated the interaction between morphological, electrical, and mechanical indicators of muscle fatigue to support the development of multidimensional fatigue monitoring approaches.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Nov 2024

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2024

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 20, 2025

Completed
23 days until next milestone

Study Completion

Last participant's last visit for all outcomes

March 15, 2025

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

June 12, 2026

Completed
12 days until next milestone

First Posted

Study publicly available on registry

June 24, 2026

Completed
Last Updated

June 24, 2026

Status Verified

June 1, 2026

Enrollment Period

4 months

First QC Date

June 12, 2026

Last Update Submit

June 18, 2026

Conditions

Keywords

Muscle FatigueSurface ElectromyographyAccelerometryMuscle ThicknessMechanomyography

Outcome Measures

Primary Outcomes (1)

  • Surface Electromyography (sEMG) Median Frequency

    Median frequency (Hz) obtained from the vastus lateralis obliquus (VLO), vastus medialis obliquus (VMO), and rectus femoris obliquus (RFO) muscles during maximal voluntary isometric contractions performed at 30°, 60°, and 90° knee flexion angles.

    Day 1

Secondary Outcomes (3)

  • Muscle Thickness

    Day 1

  • Accelerometer-Derived Mechanical Vibration Parameters

    Day 1

  • Isometric Strength Parameters

    Day 1

Study Arms (1)

Healthy Male Soccer Players

Healthy male soccer players aged 18-30 years who participated in a cross-sectional observational study. Participants underwent ultrasonographic muscle thickness assessment, surface electromyography (sEMG), accelerometer-based mechanical vibration measurements, and isometric strength testing during maximal voluntary isometric contractions performed at different knee flexion angles (30°, 60°, and 90°).

Device: Neuromuscular Assessment Devices

Interventions

Participants underwent non-invasive neuromuscular assessment procedures using surface electromyography (sEMG), triaxial accelerometers, ultrasonography, and an isokinetic dynamometer. Measurements were performed during maximal voluntary isometric contractions at 30°, 60°, and 90° knee flexion angles. The devices were used exclusively for data collection and assessment purposes. No therapeutic, pharmacological, behavioral, or rehabilitative intervention was administered.

Healthy Male Soccer Players

Eligibility Criteria

Age18 Years - 30 Years
Sexmale(Gender-based eligibility)
Gender Eligibility DetailsOnly male participants were eligible for inclusion in this study. The study was designed to evaluate muscle fatigue, muscle thickness, electromyographic, and accelerometer-derived mechanical parameters in a homogeneous sample of healthy male soccer players aged 18 to 30 years.
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Healthy male soccer players aged 18 to 30 years who were actively participating in regular football training and competition. Participants were recruited from football teams and underwent assessments of muscle thickness, surface electromyography (sEMG), accelerometer-derived mechanical vibration parameters, and isometric strength during laboratory-based testing sessions. Only individuals meeting all eligibility criteria and providing informed consent were included in the study.

You may qualify if:

  • Healthy male soccer players aged 18-30 years
  • No lower extremity injury within the previous six months
  • No condition limiting lower extremity exercise performance
  • No caffeine or stimulant consumption on the testing day
  • Non-smoker
  • Provided written informed consent

You may not qualify if:

  • Female athletes
  • Serious injury to the dominant leg within the previous year
  • Intense exercise within the previous 24 hours
  • Use of pain relievers or muscle relaxants on the testing day
  • Inability to complete testing procedures

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ordu University Faculty of Sports Sciences

Ordu, Merkez, 52100, Turkey (Türkiye)

Location

Related Publications (1)

  • Karthick PA, Venugopal G, Ramakrishnan S. Analysis of Muscle Fatigue Progression using Cyclostationary Property of Surface Electromyography Signals. J Med Syst. 2016 Jan;40(1):28. doi: 10.1007/s10916-015-0394-0. Epub 2015 Nov 7.

    PMID: 26547848BACKGROUND

Related Links

Biospecimen

Retention: SAMPLES WITHOUT DNA

No biospecimens were collected or stored in this study.

Study Officials

  • Tuğçe Namazcı, PhD

    Giresun Üniversitesi

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
research assistant

Study Record Dates

First Submitted

June 12, 2026

First Posted

June 24, 2026

Study Start

November 1, 2024

Primary Completion

February 20, 2025

Study Completion

March 15, 2025

Last Updated

June 24, 2026

Record last verified: 2026-06

Data Sharing

IPD Sharing
Will not share

Individual participant data will not be publicly shared. The study was conducted as part of a doctoral thesis, and no formal data-sharing plan has been established. Aggregate study results are reported in publications, while access to underlying data may be considered by the corresponding author on a reasonable request basis and in accordance with applicable ethical and institutional requirements.

Locations