General Versus Spinal Anesthesia in RIRS

NCT07664384 | Completed

• 1 other identifier: AIP02942671
• Study Type: observational
• Target: 252
• Locations: 1 country
• Sites: 1

Brief Summary

The impact of anesthesia type on Retrograde Intrarenal Surgery (RIRS) outcomes remains a subject of ongoing debate. Several studies have compared general anesthesia (GA) and spinal anesthesia (SA) in endourological procedures, with conflicting results regarding operative time, complication rates, and stone-free outcomes. Importantly, the interaction between anesthesia type and stone characteristics-particularly stone size-has not been fully elucidated. Therefore, this study aims to conduct a retrospective comparative analysis of general versus spinal anesthesia in patients undergoing RIRS at Qena University Hospital, with particular emphasis on the effect of stone size stratification on perioperative outcomes.

Conditions

Retrograde Intrarenal Surgery

Keywords

RIRS; Spinal Anesthesia; General Anesthesia; Perioperative Outcomes

Outcome Measures

Primary Outcomes (2)

• Stone Free Rate

  Follow-up Ultrasound/Computed Tomography (US/CT) to assess stone-free status after the first postoperative month. Success was considered as residues of \<2mm or absence of any stone fragments.

  after the first postoperative month.

• Total opioid consumption

  Total opioid consumption in the whole postoperative period is recorded

  Perioperative

Secondary Outcomes (3)

• Pain assessement

  at 6 hours, 12 hours, 24 hours

• Patient Satisfaction

  Perioperative

• PACU stay

  Perioperative

Study Arms (2)

General Anesthesia

patients in this group receive general anesthesia for RIRS: Intravenous anesthetic induction, Endotracheal intubation, controlled ventilation, muscle relaxation and inhalational anesthetic maintenance.

Spinal Anesthesia

patients in this group receive spinal anesthesia for RIRS: Standard spinal block using bupivacaine without sedation.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All eligible patients undergoing retrograde intrarenal surgery (RIRS)

You may qualify if:

• Adult patients (≥18 years) scheduled for elective RIRS for renal stones \<2 cm.
• Written informed consent obtained.

You may not qualify if:

• History of previous ureteral surgery or known ureteral stricture.
• Multiple or bilateral renal stones requiring staged procedures.

Sponsors & Collaborators

• South Valley University: lead

Study Sites (1)

Qena University

Qina, Qena Governorate, 83511, Egypt

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical professor in Anesthesia, Intensive Care and Pain Management

Study Record Dates

• First Submitted: June 15, 2026
• First Posted: June 24, 2026
• Study Start: April 1, 2022
• Primary Completion: February 1, 2025
• Study Completion: February 15, 2025
• Last Updated: July 21, 2026

Record last verified: 2026-07

Locations

EG (1)