Effect of Preoperative CIMT on Hemodynamics During Liver Transplantation

NCT07660679 | Recruiting

• 1 other identifier: 151-2026
• Study Type: observational
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

Candidates for liver transplantation (CT) carry an increased risk of cardiovascular disease (CVD) due to underlying end-stage liver disease (ESHD) and immunosuppressive drugs used post-transplantation. CVD is a significant cause of long-term mortality after CT \[1\] \[2\]. Carotid Intima-Media Thickness (CIMT), a subclinical marker of atherosclerosis in the preoperative period, is a non-invasive method used to predict future CVD risk \[3\]. High CIMT indicates atherosclerosis and decreased arterial compliance. This can compromise organ perfusion and increase the risk of postoperative complications by increasing intraoperative blood pressure variability (BPV) during anesthesia induction and surgical stress in major surgeries such as CT. Studies investigating whether CIMT is an independent risk factor for perioperative hemodynamic instability in CT patients are limited. The aim of our study is to investigate the effect of CIMT values on intraoperative hemodynamic parameters. Secondary objectives are to determine the association of CIMT with the incidence of hypotension, vasopressor requirement, postoperative acute renal injury (ARI), and major cardiac adverse events (MCAE) after anesthesia induction. Theoretical Benefit: To make a significant contribution to the literature on the relationship between atherosclerosis and anesthesia management by determining whether CIMT is an independent predictor of perioperative hemodynamic instability in chemotherapy patients. Practical Benefit: To ensure the inclusion of CIMT measurement in the anesthesia risk assessment of chemotherapy candidates. Identifying patients with high CIMT will guide the implementation of more aggressive and targeted hemodynamic management strategies (e.g., more frequent invasive monitoring, proactive vasopressor use) during anesthesia induction and maintenance.

Conditions

Liver Transplantation; Carotid Intima-media Thickness

Keywords

Liver Transplantation; Hemodynamics; Preoperative Assessment

Outcome Measures

Primary Outcomes (2)

• The Effect of Preoperative Carotid Intima-Media Thickness on Intraoperative Hemodynamic Profile in Liver Transplant Patients

  Correlation Between Preoperative Carotid Intima-Media Thickness and Intraoperative Mean Arterial Pressure

  from january 2023 to july 2026

• Correlation Between Preoperative Carotid Intima-Media Thickness and Intraoperative Vasopressor Consumption

  The correlation coefficient (r value) will be calculated to assess the linear relationship between preoperative carotid intima-media thickness (measured in millimeters via ultrasonography) and the total dose or duration of intraoperative vasopressor support (e.g., noradrenaline, ephedrine, or dopamine) required to maintain hemodynamic stability.

  from jan 2023 to july 2026

Study Arms (1)

This study includes a single group of liver transplant recipients.

Patients aged 18 and over who underwent liver transplantation (LT) at Dicle University Faculty of Medicine Hospital between January 1, 2023, and January 28, 2026, provided written informed consent, and had preoperative carotid intima-media thickness measurements will be evaluated.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients aged 18 years and older

You may qualify if:

• Patients aged between 18 and 65 years
• Scheduled for elective liver transplantation surgery
• Completed preoperative carotid intima-media thickness (CIMT) ultrasonographic measurement
• Patients with signed informed consent for data collection

You may not qualify if:

• Patients undergoing emergency liver transplantation
• History of previous carotid artery surgery or stenting
• Known severe carotid artery stenosis (\>70%)
• Severe intraoperative hemodynamic instability prior to induction (e.g., active bleeding or shock)
• Incomplete intraoperative advanced hemodynamic monitoring data or vasopressor records

Sponsors & Collaborators

• Dicle University: lead

Study Sites (1)

Dicle University Faculty of Medicine, Department of Anesthesiology and Reanimation

Diyarbakır, 21280, Turkey (Türkiye)

RECRUITING

Related Publications (5)

• Sanchez-Torrijos Y, Ampuero J, Romero-Gomez M. Cardiovascular assessment in liver transplant for non-alcoholic steatohepatitis patients: What we do, what we should do. World J Hepatol. 2017 May 28;9(15):697-703. doi: 10.4254/wjh.v9.i15.697.

  PMID: 28596817 BACKGROUND

• Perito ER, Phelps A, Vase T, Feldstein VA, Lustig RH, Rosenthal P. Subclinical Atherosclerosis in Pediatric Liver Transplant Recipients: Carotid and Aorta Intima-Media Thickness and Their Predictors. J Pediatr. 2018 Feb;193:119-127.e1. doi: 10.1016/j.jpeds.2017.10.006. Epub 2017 Dec 7.

  PMID: 29224938 BACKGROUND

• Crouse JR 3rd, Raichlen JS, Riley WA, Evans GW, Palmer MK, O'Leary DH, Grobbee DE, Bots ML; METEOR Study Group. Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR Trial. JAMA. 2007 Mar 28;297(12):1344-53. doi: 10.1001/jama.297.12.1344. Epub 2007 Mar 25.

  PMID: 17384434 BACKGROUND

• Ripoll C, Yotti R, Bermejo J, Banares R. The heart in liver transplantation. J Hepatol. 2011 Apr;54(4):810-22. doi: 10.1016/j.jhep.2010.11.003. Epub 2010 Nov 11.

  PMID: 21145840 BACKGROUND

• Maggi P, Calo F, Messina V, Stornaiuolo G, Stanzione M, Rinaldi L, De Pascalis S, Macera M, Coppola N. Cardiovascular disease risk in liver transplant recipients transplanted due to chronic viral hepatitis. PLoS One. 2022 Mar 16;17(3):e0265178. doi: 10.1371/journal.pone.0265178. eCollection 2022.

  PMID: 35294954 BACKGROUND

Study Officials

• AYHAN KAYDU, assoc. prof.

  Dicle University

  STUDY DIRECTOR

Central Study Contacts

ibrahim andan, Asst. Prof.

CONTACT

+905059051167; ibrahimandan@hotmail.com

ayhan kaydu, Assoc. Prof.

CONTACT

+90 505 556 79 39; akaydu@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: ASSOC PROF

Study Record Dates

• First Submitted: June 16, 2026
• First Posted: June 22, 2026
• Study Start: February 11, 2026
• Primary Completion: July 1, 2026
• Study Completion: July 1, 2026
• Last Updated: June 23, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)