Periodization-Based Strength Exercise Training in İndividuals With Type 2 Diabetes

NCT07659925 | Recruiting

• 1 other identifier: T2DM-NLP-2026
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled study aims to compare the effects of different periodization-based strength training approaches in individuals with type 2 diabetes mellitus. Participants will be allocated to non-linear periodization, linear periodization, or control groups. The intervention program will be conducted for 8 weeks and will evaluate exercise capacity, muscle strength, quality of life, body composition, and metabolic parameters.

Conditions

Type 2 Diabetes

Keywords

Type 2 Diabetes Mellitus; Strength Training; Non-linear Periodization; Exercise Capacity; Muscle Strength; Quality of Life; Linear Periodization; Resistance Training

Outcome Measures

Primary Outcomes (1)

• Exercise Capacity

  Exercise capacity will be assessed using the 6-Minute Walk Test (6MWT)

  Baseline and after 8 week

Secondary Outcomes (8)

• Change in Peripheral Muscle Strength

  Baseline and after 8 weeks

• Change in Hand Grip Strength

  Baseline and after 8 weeks

• Change in Diabetes Quality of Life Questionnaire Score

  Baseline and after 8 weeks

• Change in Body Fat Percentage

  Baseline and after 8 weeks

• Change in Skeletal Muscle Mass

  Baseline and after 8 weeks

Study Arms (3)

Non-linear Periodization Group

EXPERIMENTAL

Participants will receive non-linear periodization-based strength training three times per week for 8 weeks.

Behavioral: Non-linear Periodization-Based Strength Training

Linear Periodization Group

EXPERIMENTAL

Participants will receive linear periodization-based strength training three times per week for 8 weeks.

Behavioral: Linear Periodization-Based Strength Training

Control Group

ACTIVE COMPARATOR

Participants will receive usual care and no structured exercise intervention during the study period.

Other: Usual Care

Interventions

Non-linear Periodization-Based Strength Training BEHAVIORAL

Participants will perform supervised non-linear periodization-based strength training three times per week for 8 weeks.

Non-linear Periodization Group

Linear Periodization-Based Strength Training BEHAVIORAL

Participants will perform supervised linear periodization-based strength training three times per week for 8 weeks.

Linear Periodization Group

Usual Care OTHER

Participants will receive usual care and no structured exercise intervention during the study period.

Control Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged between 18 to 65 years
• Diagnosis of Type 2 Diabetes Mellitus (T2DM)
• Not having participated in any structured exercise program within the last 6 months
• Willingness to participate in the study and provide written informed consent

You may not qualify if:

• Presence of nephropathy, retinopathy, or peripheral neuropathy
• Presence of neurological, cognitive, or orthopedic disorders that may affect outcome measurements
• Severe respiratory disease (Forced Expiratory Volume in the first second \[FEV1\] \<35% or Forced Vital Capacity \[FVC\] \<50%)
• Presence of ischemic heart disease or peripheral arterial disease
• History of any cardiovascular event within the last 6 months
• Current malignancy

Sponsors & Collaborators

• Baskent University: lead

Study Sites (1)

Baskent University Hospital

Ankara, Ankara, 06790, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• Neslihan Duruturk, PhD

  Baskent University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ayşegül Erkoç, PT

CONTACT

+90 553-301-36-73; erkcaysegl@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Model Details: Participants will be assigned to one of three parallel groups: non-linear periodization-based strength training, linear periodization-based strength training, or control.

Study Record Dates

• First Submitted: June 6, 2026
• First Posted: June 22, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: June 22, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)