Inflammatory Cytokines and Oxidative Stress Biomarkers in Diabetic Chronic Kidney Disease Patients

NCT07657286 | Recruiting

• 1 other identifier: diabetic kidney disease
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This research intends to analyze how a 12-week adjustment in lifestyle influences inflammatory cytokines and oxidative stress indicators in overweight individuals diagnosed with type 2 diabetes and moderate CKD

Conditions

Chronic Kidney Disease; Diabetes

Keywords

Diabetes; Weight Reduction; Oxidative Stress; Cytokines; Obesity.

Outcome Measures

Primary Outcomes (7)

• MDA

  malondialdehyde

  at baseline and after 12 WEEKS

• GSH

  Glutathione

  at baseline and after 12 WEEKS

• GPx

  Glutathione peroxidase

  at baseline and after 12 WEEKS

• SOD

  Superoxide dismutase

  at baseline and after 12 WEEKS

• IL-6

  Interleukin-6

  at baseline and after 12 WEEKS

• TNF-α

  tumor necrosis factor alpha

  at baseline and after 12 WEEKS

• CRP

  C-reactive protein

  at baseline and after 12 WEEKS

Secondary Outcomes (1)

• BMI

  at baseline and after 12 WEEKS

Study Arms (2)

(Group A)

EXPERIMENTAL

Participants completed supervised aerobic treadmill exercises while sticking to a calorie-limited diet (1200 kcal/day) throughout a 12-week period.

Other: aerobic treadmill exercises

group (B)

NO INTERVENTION

Participants received standard nephrology care without any alterations in lifestyle.

Interventions

aerobic treadmill exercises OTHER

diet (1200 kcal/day)

Also known as: a calorie-limited diet (1200 kcal/day)

(Group A)

Eligibility Criteria

• Age: 36 Years - 58 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• sedentary lifestyle for at least three months prior to enrollment
• body mass index (BMI) of 30-35 kg/m².

You may not qualify if:

• using tobacco
• heart failure
• coronary arteries
• severe heart valve problems
• pregnant
• liver inflammation
• kidney transplant
• physical injuries restricting them from exercising
• utilization of anti-inflammatory medications

Sponsors & Collaborators

• Badr University: lead

Study Sites (1)

Mona Mohamed Abdelkhalek

Cairo, Egypt

RECRUITING

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Diabetes Mellitus; Weight Loss; Obesity

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Body Weight Changes; Body Weight; Signs and Symptoms; Overweight; Overnutrition; Nutrition Disorders

Study Officials

• Mona Mohamed Abdelkhalek

  Badr University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mona Mohamed Abdelkhalek, assistance professor

CONTACT

00201024056108; 3m.sons@gmail.com

Mona Mohamed Abdelkhalek, assistance professor

CONTACT

00201024056108; mona.abdelkhalek@buc.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistance professor

Study Record Dates

• First Submitted: June 14, 2026
• First Posted: June 18, 2026
• Study Start: June 7, 2026
• Primary Completion (Estimated): September 7, 2026
• Study Completion (Estimated): September 7, 2026
• Last Updated: June 18, 2026

Record last verified: 2026-06

Locations

EG (1)