Exercise On Bone Metabolism Markers In Chronic Kidney Disease

NCT07628621 | Completed

• 1 other identifier: SU.REC.2025(45H)
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Sixty chronic kidney disease patients, Measurement of bone turnover markers done prior to the study and at the end of the study after 6 months.

Conditions

Chronic Kidney Diseases

Outcome Measures

Primary Outcomes (2)

• serum osteoprotegerin (OPG)

  An overnight fasting venous blood sample was drained, centrifuged and stored at -70 °C

  at baseline and after six month

• receptor activator of nuclear factor kappa B ligand

  An overnight fasting venous blood sample was drained, centrifuged and stored at -70 °C

  at baseline and after six month

Secondary Outcomes (1)

• Bone mineral density (BMD)

  at baseline and after six month

Study Arms (2)

Group (A)

EXPERIMENTAL

Participants received resisted exercise training on some resistance machines

Other: resisted exercise training on some resistance machines

group (B)

EXPERIMENTAL

Participants received treadmill exercise training

Other: treadmill exercise training

Interventions

resisted exercise training on some resistance machines OTHER

resistance exercises on some resistance machines, 3 sessions of exercise training /week

Group (A)

treadmill exercise training OTHER

treadmill aerobic exercise (intensity equal 60-80 % of each individual maximum heart rate)

group (B)

Eligibility Criteria

• Age: 30 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Non-smokers,
• no alcohol consumption
• no intake of hormone replacement therapy
• mass index ranged from 20-24 kg/m2.

You may not qualify if:

• diabetes disorders
• hypertension disorders
• cardiac disorders
• musculoskeletal disorders
• endocrine disorders
• intake of medications that may affect bone metabolism.

Sponsors & Collaborators

• Badr University: lead

Study Sites (1)

Badr university

Cairo, Egypt

Location

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: double
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistance professor

Model Details: Participants included in two groups. Group (A) received resisted exercise training on some resistance machines where; group (B) received treadmill exercise training

Study Record Dates

• First Submitted: June 1, 2026
• First Posted: June 5, 2026
• Study Start: December 1, 2025
• Primary Completion: May 30, 2026
• Study Completion: May 30, 2026
• Last Updated: June 5, 2026

Record last verified: 2026-06

Locations

EG (1)