NCT07652398

Brief Summary

This randomized crossover trial will investigate the acute effects of five passive recovery interventions following a standardized high-intensity cycling exercise protocol. Participants will complete one supervised high-intensity cycling session per week for five consecutive weeks. Immediately after each exercise session, participants will receive one of five recovery interventions: compression therapy, vacuum therapy, kinesiology taping, passive rest, or classical massage. The order of the interventions will be randomized according to a balanced crossover sequence. Each participant will experience all five recovery interventions during the study period. Outcomes related to post-exercise recovery will be assessed across intervention periods.

Trial Health

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Trial Health Score

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Enrollment
10

participants targeted

Target at below P25 for not_applicable

Timeline
17mo left

Started Jun 2026

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 10, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

June 17, 2026

Completed
3 days until next milestone

Study Start

First participant enrolled

June 20, 2026

Expected
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 20, 2026

1.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

October 30, 2027

Last Updated

June 17, 2026

Status Verified

April 1, 2026

Enrollment Period

3 months

First QC Date

June 10, 2026

Last Update Submit

June 16, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Total Quality Recovery (TQR) Score

    Recovery status assessed using the Total Quality Recovery (TQR) scale following each recovery intervention.

    Baseline, immediately after recovery intervention, and 24 hours after exercise

Secondary Outcomes (7)

  • Perceived Recovery Status

    Baseline, immediately after the recovery intervention, and 24 hours after exercise

  • Rating of Perceived Exertion (RPE)

    Immediately after exercise

  • Muscle Soreness Visual Analog Scale (VAS)

    Baseline, immediately after the recovery intervention, and 24 hours after exercise

  • Vertical Jump Performance

    Baseline, immediately after the recovery intervention, and 24 hours after exercise

  • Sit-and-Reach Test

    Baseline, immediately after the recovery intervention, and 24 hours after exercise

  • +2 more secondary outcomes

Study Arms (5)

Sequence A: Compression-Vacuum-KT-Rest-Massage

EXPERIMENTAL

Participants randomized to Sequence A will complete a standardized high-intensity cycling exercise session once weekly for five consecutive weeks. Immediately after each session, they will receive recovery interventions in the following order: Week 1 compression therapy, Week 2 vacuum therapy, Week 3 kinesiology taping, Week 4 passive rest, and Week 5 classical massage.

Behavioral: High-Intensity Cycling Exercise ProtocolDevice: Doctor Life MK400L Sequential Intermittent Compression DeviceDevice: Intelect Neo Therapy System with Chattanooga Intelect Neo Vacuum ModuleOther: Kinesiology TapingOther: Passive RestOther: Classical Massage

Sequence B: Vacuum-KT-Rest-Massage-Compression

EXPERIMENTAL

Participants randomized to Sequence B will complete a standardized high-intensity cycling exercise session once weekly for five consecutive weeks. Immediately after each session, they will receive recovery interventions in the following order: Week 1 vacuum therapy, Week 2 kinesiology taping, Week 3 passive rest, Week 4 classical massage, and Week 5 compression therapy.

Behavioral: High-Intensity Cycling Exercise ProtocolDevice: Doctor Life MK400L Sequential Intermittent Compression DeviceDevice: Intelect Neo Therapy System with Chattanooga Intelect Neo Vacuum ModuleOther: Kinesiology TapingOther: Passive RestOther: Classical Massage

Sequence C: KT-Rest-Massage-Compression-Vacuum

EXPERIMENTAL

Participants randomized to Sequence C will complete a standardized high-intensity cycling exercise session once weekly for five consecutive weeks. Immediately after each session, they will receive recovery interventions in the following order: Week 1 kinesiology taping, Week 2 passive rest, Week 3 classical massage, Week 4 compression therapy, and Week 5 vacuum therapy.

Behavioral: High-Intensity Cycling Exercise ProtocolDevice: Doctor Life MK400L Sequential Intermittent Compression DeviceDevice: Intelect Neo Therapy System with Chattanooga Intelect Neo Vacuum ModuleOther: Kinesiology TapingOther: Passive RestOther: Classical Massage

Sequence D: Rest-Massage-Compression-Vacuum-KT

EXPERIMENTAL

Participants randomized to Sequence D will complete a standardized high-intensity cycling exercise session once weekly for five consecutive weeks. Immediately after each session, they will receive recovery interventions in the following order: Week 1 passive rest, Week 2 classical massage, Week 3 compression therapy, Week 4 vacuum therapy, and Week 5 kinesiology taping.

Behavioral: High-Intensity Cycling Exercise ProtocolDevice: Doctor Life MK400L Sequential Intermittent Compression DeviceDevice: Intelect Neo Therapy System with Chattanooga Intelect Neo Vacuum ModuleOther: Kinesiology TapingOther: Passive RestOther: Classical Massage

Sequence E: Massage-Compression-Vacuum-KT-Rest

EXPERIMENTAL

Participants randomized to Sequence E will complete a standardized high-intensity cycling exercise session once weekly for five consecutive weeks. Immediately after each session, they will receive recovery interventions in the following order: Week 1 classical massage, Week 2 compression therapy, Week 3 vacuum therapy, Week 4 kinesiology taping, and Week 5 passive rest.

Behavioral: High-Intensity Cycling Exercise ProtocolDevice: Doctor Life MK400L Sequential Intermittent Compression DeviceDevice: Intelect Neo Therapy System with Chattanooga Intelect Neo Vacuum ModuleOther: Kinesiology TapingOther: Passive RestOther: Classical Massage

Interventions

All participants will perform a standardized supervised high-intensity cycling exercise protocol once weekly for five consecutive weeks. The cycling protocol will be administered before the assigned recovery intervention in each study period. Exercise intensity, duration, and progression will be standardized across participants and sessions.

Sequence A: Compression-Vacuum-KT-Rest-MassageSequence B: Vacuum-KT-Rest-Massage-CompressionSequence C: KT-Rest-Massage-Compression-VacuumSequence D: Rest-Massage-Compression-Vacuum-KTSequence E: Massage-Compression-Vacuum-KT-Rest

Compression therapy will be administered using the Doctor Life MK400L 6-chamber sequential intermittent compression device, code MK4L250-BL. The intervention will be applied immediately after the standardized high-intensity cycling exercise session. The application will be delivered according to a standardized protocol, including participant positioning, treated body region, application duration, and device settings.

Also known as: Doctor Life MK400L, MK4L250-BL, 6-Chamber Sequential Intermittent Compression Device, Compression Therapy
Sequence A: Compression-Vacuum-KT-Rest-MassageSequence B: Vacuum-KT-Rest-Massage-CompressionSequence C: KT-Rest-Massage-Compression-VacuumSequence D: Rest-Massage-Compression-Vacuum-KTSequence E: Massage-Compression-Vacuum-KT-Rest

Vacuum therapy will be administered using the Intelect Neo Therapy System with the Chattanooga Intelect Neo Vacuum Module. The intervention will be applied immediately after the standardized high-intensity cycling exercise session. The application will be delivered according to a standardized protocol, including participant positioning, treated body region, application duration, vacuum cup placement, and vacuum pressure settings.

Also known as: Intelect Neo, Chattanooga Intelect Neo Vacuum Module, Vacuum Therapy, Vacuum-Assisted Therapy
Sequence A: Compression-Vacuum-KT-Rest-MassageSequence B: Vacuum-KT-Rest-Massage-CompressionSequence C: KT-Rest-Massage-Compression-VacuumSequence D: Rest-Massage-Compression-Vacuum-KTSequence E: Massage-Compression-Vacuum-KT-Rest

Kinesiology taping will be applied immediately after the standardized high-intensity cycling exercise session by a trained physiotherapist. Tape placement, application technique, tension, target region, and wear time will be standardized across participants.

Sequence A: Compression-Vacuum-KT-Rest-MassageSequence B: Vacuum-KT-Rest-Massage-CompressionSequence C: KT-Rest-Massage-Compression-VacuumSequence D: Rest-Massage-Compression-Vacuum-KTSequence E: Massage-Compression-Vacuum-KT-Rest

Participants will rest quietly after the standardized high-intensity cycling exercise session for a standardized duration. No manual therapy, mechanical therapy, taping, or additional recovery intervention will be administered during the passive rest condition.

Sequence A: Compression-Vacuum-KT-Rest-MassageSequence B: Vacuum-KT-Rest-Massage-CompressionSequence C: KT-Rest-Massage-Compression-VacuumSequence D: Rest-Massage-Compression-Vacuum-KTSequence E: Massage-Compression-Vacuum-KT-Rest

Classical massage will be administered immediately after the standardized high-intensity cycling exercise session by a trained physiotherapist. The treated body region, massage techniques, sequence of techniques, pressure, and application duration will be standardized across participants.

Sequence A: Compression-Vacuum-KT-Rest-MassageSequence B: Vacuum-KT-Rest-Massage-CompressionSequence C: KT-Rest-Massage-Compression-VacuumSequence D: Rest-Massage-Compression-Vacuum-KTSequence E: Massage-Compression-Vacuum-KT-Rest

Eligibility Criteria

Age18 Years - 30 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy adult volunteers aged 18-35 years
  • Able to perform high-intensity cycling exercise
  • No musculoskeletal injury within the last six months
  • No known cardiovascular, neurological, or metabolic disease
  • Not using medication that may affect exercise performance, pain perception, or recovery
  • Willing to attend all five study sessions
  • Willing to receive all five passive recovery interventions
  • Provided written informed consent

You may not qualify if:

  • Presence of acute or chronic musculoskeletal injury
  • History of cardiovascular, neurological, respiratory, or metabolic disease
  • Contraindication to high-intensity exercise
  • Contraindication to compression therapy, vacuum therapy, kinesiology taping, passive rest, or classical massage
  • Skin allergy, open wound, dermatological disease, or sensitivity to kinesiology tape
  • Use of analgesic, anti-inflammatory, muscle relaxant, or performance-enhancing medication during the study period
  • Participation in another exercise or recovery intervention study during the study period
  • Failure to attend all study sessions or comply with study procedures

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Interventions

Negative-Pressure Wound Therapy

Intervention Hierarchy (Ancestors)

DrainageTherapeuticsSurgical Procedures, OperativeWound Closure Techniques

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
CROSSOVER
Model Details: Participants will be randomized to one of five balanced crossover sequences. All participants will complete the same standardized high-intensity cycling exercise protocol once weekly for five weeks. After each exercise session, participants will receive one of five passive recovery interventions. Each participant will receive all five interventions, but the order of interventions will differ according to the randomized sequence.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor, Faculty of Physiotherapy and Rehabilitation

Study Record Dates

First Submitted

June 10, 2026

First Posted

June 17, 2026

Study Start (Estimated)

June 20, 2026

Primary Completion (Estimated)

September 20, 2026

Study Completion (Estimated)

October 30, 2027

Last Updated

June 17, 2026

Record last verified: 2026-04