NCT07652398

Brief Summary

This randomized crossover trial will investigate the acute effects of five passive recovery interventions following a standardized high-intensity cycling exercise protocol. Participants will complete the standardized high-intensity cycling exercise protocol during five separate study sessions. Immediately after each exercise session, participants will receive one of five recovery interventions: compression therapy, vacuum therapy, kinesiology taping, passive rest, or classical massage. The order of the interventions will be randomized according to a balanced crossover sequence. Each participant will experience all five recovery interventions during the study period. Outcomes related to post-exercise recovery will be assessed across intervention periods.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
12

participants targeted

Target at below P25 for not_applicable

Timeline
1mo left

Started Jun 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress71%
Jun 2026Aug 2026

First Submitted

Initial submission to the registry

June 10, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

June 17, 2026

Completed
5 days until next milestone

Study Start

First participant enrolled

June 22, 2026

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 14, 2026

Expected
7 days until next milestone

Study Completion

Last participant's last visit for all outcomes

August 21, 2026

Last Updated

July 14, 2026

Status Verified

April 1, 2026

Enrollment Period

2 months

First QC Date

June 10, 2026

Last Update Submit

July 10, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Total Quality Recovery (TQR) Score

    Recovery status assessed using the Total Quality Recovery (TQR) scale following each recovery intervention.

    At each of the five study sessions: immediately after completion of the 30-minute recovery period and 24 hours after completion of the high-intensity cycling exercise.

Secondary Outcomes (8)

  • Perceived Recovery Status

    At each of the five study sessions: immediately before exercise, immediately after completion of the 30-minute recovery period, and 24 hours after completion of the high-intensity cycling exercise.

  • Rating of Perceived Exertion (RPE)

    At each of the five study sessions: immediately before exercise and immediately after completion of the 15-minute high-intensity cycling bout, before the cool-down and recovery intervention.

  • Fatigue Visual Analog Scale (VAS)

    At each of the five study sessions: immediately before exercise; immediately after the 15-minute high-intensity cycling bout; immediately after the 30-minute recovery period; and 24 hours after completion of cycling exercise.

  • Muscle Soreness Visual Analog Scale (VAS)

    At each of the five study sessions: immediately before exercise; immediately after completion of the standardized cool-down and before initiation of the 30-minute recovery period; immediately after the 30-minute recovery period; and 24 hours after cyclin

  • Vertical Jump Performance

    At each of the five study sessions: immediately before exercise; immediately after completion of the standardized cool-down and before initiation of the 30-minute recovery period; immediately after the 30-minute recovery period; and 24 hours after cyclin

  • +3 more secondary outcomes

Study Arms (5)

Sequence A: Compression-Vacuum-KT-Rest-Massage

EXPERIMENTAL

Participants randomized to Sequence A will complete a standardized high-intensity cycling exercise protocol during five separate study sessions. Immediately after each session, they will receive recovery interventions in the following order: Session 1 compression therapy, Session 2 vacuum therapy, Session 3 kinesiology taping, Session 4 passive rest, and Session 5 classical massage.

Behavioral: High-Intensity Cycling Exercise ProtocolDevice: Doctor Life MK400L Sequential Intermittent Compression DeviceDevice: Intelect Neo Therapy System with Chattanooga Intelect Neo Vacuum ModuleOther: Kinesiology TapingOther: Passive RestOther: Classical Massage

Sequence B: Vacuum-KT-Rest-Massage-Compression

EXPERIMENTAL

Participants randomized to Sequence B will complete a standardized high-intensity cycling exercise protocol during five separate study sessions. Immediately after each session, they will receive recovery interventions in the following order: Session 1 vacuum therapy, Session 2 kinesiology taping, Session 3 passive rest, Session 4 classical massage, and Session 5 compression therapy.

Behavioral: High-Intensity Cycling Exercise ProtocolDevice: Doctor Life MK400L Sequential Intermittent Compression DeviceDevice: Intelect Neo Therapy System with Chattanooga Intelect Neo Vacuum ModuleOther: Kinesiology TapingOther: Passive RestOther: Classical Massage

Sequence C: KT-Rest-Massage-Compression-Vacuum

EXPERIMENTAL

Participants randomized to Sequence C will complete a standardized high-intensity cycling exercise protocol during five separate study sessions. Immediately after each session, they will receive recovery interventions in the following order: Session 1 kinesiology taping, Session 2 passive rest, Session 3 classical massage, Session 4 compression therapy, and Session 5 vacuum therapy.

Behavioral: High-Intensity Cycling Exercise ProtocolDevice: Doctor Life MK400L Sequential Intermittent Compression DeviceDevice: Intelect Neo Therapy System with Chattanooga Intelect Neo Vacuum ModuleOther: Kinesiology TapingOther: Passive RestOther: Classical Massage

Sequence D: Rest-Massage-Compression-Vacuum-KT

EXPERIMENTAL

Participants randomized to Sequence D will complete a standardized high-intensity cycling exercise protocol during five separate study sessions. Immediately after each session, they will receive recovery interventions in the following order: Session 1 passive rest, Session 2 classical massage, Session 3 compression therapy, Session 4 vacuum therapy, and Session 5 kinesiology taping.

Behavioral: High-Intensity Cycling Exercise ProtocolDevice: Doctor Life MK400L Sequential Intermittent Compression DeviceDevice: Intelect Neo Therapy System with Chattanooga Intelect Neo Vacuum ModuleOther: Kinesiology TapingOther: Passive RestOther: Classical Massage

Sequence E: Massage-Compression-Vacuum-KT-Rest

EXPERIMENTAL

Participants randomized to Sequence E will complete a standardized high-intensity cycling exercise protocol during five separate study sessions. Immediately after each session, they will receive recovery interventions in the following order: Session 1 classical massage, Session 2 compression therapy, Session 3 vacuum therapy, Session 4 kinesiology taping, and Session 5 passive rest.

Behavioral: High-Intensity Cycling Exercise ProtocolDevice: Doctor Life MK400L Sequential Intermittent Compression DeviceDevice: Intelect Neo Therapy System with Chattanooga Intelect Neo Vacuum ModuleOther: Kinesiology TapingOther: Passive RestOther: Classical Massage

Interventions

All participants will perform a standardized supervised high-intensity cycling exercise protocol during five separate study sessions. The cycling protocol will be administered before the assigned recovery intervention in each study period. Exercise intensity, duration, and progression will be standardized across participants and sessions.

Sequence A: Compression-Vacuum-KT-Rest-MassageSequence B: Vacuum-KT-Rest-Massage-CompressionSequence C: KT-Rest-Massage-Compression-VacuumSequence D: Rest-Massage-Compression-Vacuum-KTSequence E: Massage-Compression-Vacuum-KT-Rest

Compression therapy will be administered using the Doctor Life MK400L 6-chamber sequential intermittent compression device, code MK4L250-BL. The intervention will be applied immediately after the standardized high-intensity cycling exercise session. The application will be delivered according to a standardized protocol, including participant positioning, treated body region, application duration, and device settings.

Also known as: Doctor Life MK400L, MK4L250-BL, 6-Chamber Sequential Intermittent Compression Device, Compression Therapy
Sequence A: Compression-Vacuum-KT-Rest-MassageSequence B: Vacuum-KT-Rest-Massage-CompressionSequence C: KT-Rest-Massage-Compression-VacuumSequence D: Rest-Massage-Compression-Vacuum-KTSequence E: Massage-Compression-Vacuum-KT-Rest

Kinesiology taping will be applied immediately after the standardized high-intensity cycling exercise session by a trained physiotherapist. Tape placement, application technique, tension, target region, and wear time will be standardized across participants.

Sequence A: Compression-Vacuum-KT-Rest-MassageSequence B: Vacuum-KT-Rest-Massage-CompressionSequence C: KT-Rest-Massage-Compression-VacuumSequence D: Rest-Massage-Compression-Vacuum-KTSequence E: Massage-Compression-Vacuum-KT-Rest

Participants will rest quietly after the standardized high-intensity cycling exercise session for a standardized duration. No manual therapy, mechanical therapy, taping, or additional recovery intervention will be administered during the passive rest condition.

Sequence A: Compression-Vacuum-KT-Rest-MassageSequence B: Vacuum-KT-Rest-Massage-CompressionSequence C: KT-Rest-Massage-Compression-VacuumSequence D: Rest-Massage-Compression-Vacuum-KTSequence E: Massage-Compression-Vacuum-KT-Rest

Classical massage will be administered immediately after the standardized high-intensity cycling exercise session by a trained physiotherapist. The treated body region, massage techniques, sequence of techniques, pressure, and application duration will be standardized across participants.

Sequence A: Compression-Vacuum-KT-Rest-MassageSequence B: Vacuum-KT-Rest-Massage-CompressionSequence C: KT-Rest-Massage-Compression-VacuumSequence D: Rest-Massage-Compression-Vacuum-KTSequence E: Massage-Compression-Vacuum-KT-Rest

Vacuum therapy will be administered using the Intelect Neo Therapy System with the Chattanooga Intelect Neo Vacuum Module. The intervention will be applied immediately after the standardized high-intensity cycling exercise session. The application will be delivered according to a standardized protocol, including participant positioning, treated body region, application duration, vacuum cup placement, and vacuum pressure settings.

Also known as: Intelect Neo, Chattanooga Intelect Neo Vacuum Module, Vacuum Therapy, Vacuum-Assisted Therapy
Sequence A: Compression-Vacuum-KT-Rest-MassageSequence B: Vacuum-KT-Rest-Massage-CompressionSequence C: KT-Rest-Massage-Compression-VacuumSequence D: Rest-Massage-Compression-Vacuum-KTSequence E: Massage-Compression-Vacuum-KT-Rest

Eligibility Criteria

Age18 Years - 30 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy adult volunteers aged 18-30 years
  • Able to perform high-intensity cycling exercise
  • No musculoskeletal injury within the last six months
  • No known cardiovascular, neurological, or metabolic disease
  • Not using medication that may affect exercise performance, pain perception, or recovery
  • Willing to attend all five study sessions
  • Willing to receive all five passive recovery interventions
  • Provided written informed consent

You may not qualify if:

  • Presence of acute or chronic musculoskeletal injury
  • History of cardiovascular, neurological, respiratory, or metabolic disease
  • Contraindication to high-intensity exercise
  • Contraindication to compression therapy, vacuum therapy, kinesiology taping, passive rest, or classical massage
  • Skin allergy, open wound, dermatological disease, or sensitivity to kinesiology tape
  • Use of analgesic, anti-inflammatory, muscle relaxant, or performance-enhancing medication during the study period
  • Participation in another exercise or recovery intervention study during the study period
  • Failure to attend all study sessions or comply with study procedures

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Pamukkale University, Faculty of Physiotherapy and Rehabilitation

Denizli, Turkey (Türkiye)

RECRUITING

MeSH Terms

Interventions

Negative-Pressure Wound Therapy

Intervention Hierarchy (Ancestors)

DrainageTherapeuticsSurgical Procedures, OperativeWound Closure Techniques

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
CROSSOVER
Model Details: Participants will be randomized to one of five balanced crossover sequences. All participants will complete the same standardized high-intensity cycling exercise protocol during five separate study sessions. After each exercise session, participants will receive one of five passive recovery interventions. Each participant will receive all five interventions, but the order of interventions will differ according to the randomized sequence.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor, Faculty of Physiotherapy and Rehabilitation

Study Record Dates

First Submitted

June 10, 2026

First Posted

June 17, 2026

Study Start

June 22, 2026

Primary Completion (Estimated)

August 14, 2026

Study Completion (Estimated)

August 21, 2026

Last Updated

July 14, 2026

Record last verified: 2026-04

Locations