Left Atrial and Left Ventricular Structural and Functional Evaluation by CCTA for Predicting Post-Ablation Outcomes in Patients With Atrial Fibrillation

NCT07651046 | Withdrawn

• 1 other identifier: KY20250327-05
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate whether structural and functional parameters of the left atrium and left ventricle, measured by cardiac computed tomography angiography (CCTA), can predict clinical outcomes after radiofrequency ablation in patients with atrial fibrillation (AF). Atrial fibrillation is a common heart rhythm disorder, and while catheter ablation is an effective treatment, some patients experience recurrence. Current predictive tools have limitations. This prospective observational study will enroll patients with AF scheduled for first-time radiofrequency ablation. All participants will undergo CCTA before the ablation procedure to assess left atrial and left ventricular volumes, ejection fraction, and strain parameters. After ablation, patients will be followed for 12 months to monitor recurrence of atrial arrhythmias. The primary outcome is the recurrence of atrial fibrillation or atrial tachycardia lasting more than 30 seconds after a 3-month blanking period. The study will determine whether CCTA-derived parameters improve risk stratification for post-ablation recurrence. Findings may help identify patients who are more likely to benefit from ablation or who may need additional therapy.

Conditions

Atrial Fibrillation (AF)

Outcome Measures

Primary Outcomes (1)

• Recurrence of atrial arrhythmia after ablation

  Recurrence of atrial fibrillation, atrial flutter, or atrial tachycardia lasting 30 seconds or longer, documented by electrocardiogram (ECG) or Holter monitoring, after a 3-month blanking period following radiofrequency ablation.

  12 months after ablation (following the initial 3-month blanking period)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients with paroxysmal or persistent atrial fibrillation referred for first-time radiofrequency catheter ablation at Nanjing First Hospital.

You may qualify if:

• Meet the indications for radiofrequency ablation recommended by relevant atrial fibrillation diagnosis and treatment guidelines
• Age ≥ 18 years
• First-time radiofrequency ablation

You may not qualify if:

• history of cardiac ablation
• structural heart diseases, such as cardiomyopathy, valvular disease, heart failure, and acute myocardial infarction
• severe renal failure (estimated glomerular filtration rate \<30 ml/m2)
• left ventricular (LV) ejection fraction \<30%
• poor image quality inadequate for assessment

Sponsors & Collaborators

• Nanjing First Hospital, Nanjing Medical University: lead

Study Sites (1)

Nanjing First Hospital, Nanjing Medical University, 68 Changle road, Qinhuai District

Nanjing, Jiangsu, 210006, China

Location

MeSH Terms

Conditions

Atrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 11, 2026
• First Posted: June 16, 2026
• Study Start: August 15, 2024
• Primary Completion (Estimated): August 1, 2028
• Study Completion (Estimated): August 1, 2028
• Last Updated: June 22, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)