Impact of Pre-Ablation Prehabilitation on Clinical Outcomes and Cardiorespiratory Fitness in Atrial Fibrillation Patients

NCT07270757 | Recruiting DMC

• 1 other identifier: 2025-SR-429
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective of this study is to compare the effects of a preoperative prehabilitation program versus usual care on post-procedural cardiorespiratory function and clinical outcomes in patients undergoing catheter ablation for atrial fibrillation.

Conditions

Atrial Fibrillation (AF)

Keywords

Atrial Fibrillation; Cardiac rehabilitation

Outcome Measures

Primary Outcomes (2)

• Peak Oxygen Uptake at 3 months

  Measure: Cardiopulmonary exercise testing

  3 months post-ablation

• Atrial Arrhythmic Events within 90 days

  Any atrial arrhythmic events happened within 90 days after the procedure

  Within 90 days post-ablation

Study Arms (2)

Prehabilitation Group

EXPERIMENTAL

Structured Prehabilitation Program for 4 weeks before ablation

Other: 4-week structured prehabilitation program (exercise training + psychological education)

Usual Care Group

NO INTERVENTION

Standard Preoperative Care

Interventions

4-week structured prehabilitation program (exercise training + psychological education) OTHER

The prehabilitation group will receive a 4-week structured program before ablation, including: Individualized exercise training: Prescription based on cardiopulmonary exercise test results, including aerobic exercise (40%-60% of heart rate reserve) and resistance training Psychological and educational intervention: Structured education based on cognitive behavioral therapy principles, focusing on addressing kinesiophobia Delivery mode: Hybrid (supervised in-hospital sessions + monitored home-based sessions) The usual care group will receive only standard preoperative education without structured rehabilitation.

Prehabilitation Group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged 18-70 years
• Scheduled for first AF ablation
• NYHA class I-II
• LVEF ≥ 50%

You may not qualify if:

• Significant structural heart disease (e.g., severe valvular disease)
• Contraindications to CPET or exercise training
• Cognitive impairment preventing cooperation

Sponsors & Collaborators

• Nanjing Medical University: lead

Study Sites (1)

The First Affiliated Hospital with Nanjing Medical University

Nanjing, Please Select, China

RECRUITING

MeSH Terms

Conditions

Atrial Fibrillation

Interventions

Exercise

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Kexin Wang

CONTACT

+8618018223427; 840507356@qq.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: The First Affiliated Hospital with Nanjing Medical University

Study Record Dates

• First Submitted: November 26, 2025
• First Posted: December 8, 2025
• Study Start: February 1, 2025
• Primary Completion: February 1, 2026
• Study Completion: March 1, 2026
• Last Updated: December 8, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)