Influence of Cardiopulmonary Rehabilitation on Cardiorespiratory Adaptation in Patients With Pulmonary Hypertension

NCT07648524 | Not Yet Recruiting

• 1 other identifier: P.T.REC/012/005518
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the effect of cardiopulmonary rehabilitation on cardiorespiratory parameters and functional capacity in patients with pulmonary hypertension.

Conditions

Pulmonary Hypertension Due to Lung Disease (Disorder)

Keywords

Pulmonary Hypertension Cardiopulmonary Rehabilitation Inspiratory Muscle Training Exercise Training Functional Capacity Pulmonary Function

Outcome Measures

Primary Outcomes (3)

• 6-minute walk distance

  total distance walked in 6 minutes

  12 weeks

• Maximal Oxygen Consumption

  Estimated VO2max

  12weeks

• spirometry

  FEV1, FVC, FEV1/FVC, MVV

  12weeks

Secondary Outcomes (3)

• Dyspnea Severity

  12weeks

• change Pulmonary Artery Pressure

  12weeks

• change of total score of SF-12 Questionnaire) Quality of Life

  12weeks

Study Arms (4)

group III PH with obstructive lung disease

EXPERIMENTAL

Group (A), (n =16) patients with group III PH with obstructive lung disease will receive cardiopulmonary Rehabilitation in the form of moderate-intensity interval aerobic training and inspiratory muscle training in addition to the routine medical treatment.

Behavioral: cardiopulmonary rehabilitation in the form of moderate-intensity interval aerobic training; Device: Inspiratory Muscle Training

group III PHT with restrictive lung disease

EXPERIMENTAL

group (B), (n =16) patients with group III PHT with restrictive lung disease will receive cardiopulmonary rehabilitation in the form of moderate-intensity interval aerobic training and inspiratory muscle training in addition to the routine medical treatment.

Behavioral: cardiopulmonary rehabilitation in the form of moderate-intensity interval aerobic training; Device: Inspiratory Muscle Training

control group III PH with obstructive lung disease

EXPERIMENTAL

Group (c), (n =5) patients with group III PH with obstructive lung disease will receive medical treatment only

Other: Medical treatment

control group III PHT with restrictive lung disease

EXPERIMENTAL

Group (D), (n =5) patients with group III PH with restrictive lung disease will receive medical treatment only

Other: Medical treatment

Interventions

cardiopulmonary rehabilitation in the form of moderate-intensity interval aerobic training BEHAVIORAL

Training will be conducted on a treadmill three times weekly for 12 weeks. Exercise intensity will progress from 30-40% to 60-70% of target heart rate. Each session will last 30 minutes and include warm-up and cool-down periods.

group III PH with obstructive lung disease; group III PHT with restrictive lung disease

Inspiratory Muscle Training DEVICE

inspiratory muscle training will be performed using a Threshold Inspiratory Muscle Trainer (Philips Respironics). Training intensity will correspond to moderate-to-severe effort (3-5 on the Modified Borg Scale).

group III PH with obstructive lung disease; group III PHT with restrictive lung disease

Medical treatment OTHER

medication

control group III PH with obstructive lung disease; control group III PHT with restrictive lung disease

Eligibility Criteria

• Age: 45 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \- a)Medically stable pulmonary hypertension patients who were under optimized medical therapy. b)Pulmonary artery pressure ≥ 25 mmHg confirmed by RT side heart catheterization.
• c)Forty two male patients with group 3 pulmonary hypertension (Chest cause) include Obstructive lung disease ( COPD and sleep apnea ) and restrictive lung disease (ILD). d)The patients' ages will range from 45 to 65 years old. e)BMI (25 - 34.9) kg/m2. f)World Health Organization (WHO) classification of functional classes II to III ( class II are patients with pulmonary hypertension who have a mild limitation of physical activity )(class III are patients with pulmonary hypertension who have a marked limitation of physical activity

You may not qualify if:

• g)Uncontrolled systemic HTN. h)Other types of pulmonary hypertension.. i)Smoker j)Any condition of kidney failure. k)Neurological or musculoskeletal conditions that interfere with gait
• l)Impaired vision and/or hearing.
• m)Patients who are unable to follow verbal instructions. n)acute exacerbation condition. o)unstable angina, serious cardiac dysrhythmias on resting ECG.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Faculty of Physical Therapy ,Cairo University

Giza, Egypt

Location

Study Officials

• NESREEN GHAREEB MOHAMED EL-NAHAS, Prof PT

  faculty of P.T. Cairo University

  STUDY CHAIR

• HEBA AHMED ALI ABDEEN, Prof

  faculty of P.T. Cairo University

  STUDY CHAIR

• HEND ABD EL-MONAEM ABD EL-MONAEM, Lecturer of physical therapy

  faculty of P.T. Cairo University

  STUDY CHAIR

• REEM IBRAHIM EL KORASHY, prof of pulmonology

  Cairo University

  STUDY CHAIR

Central Study Contacts

Rana Essam El Din Abd Elbar, Assistant lecturer

CONTACT

01013981766; rana.essam@acu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 10, 2026
• First Posted: June 15, 2026
• Study Start: June 13, 2026
• Primary Completion (Estimated): September 13, 2026
• Study Completion (Estimated): September 13, 2026
• Last Updated: June 15, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)