Corneal Epithelial Thickness Mapping by Anterior Segment Optical Coherence Tomography in Patients With Refractive Errors

NCT07647146 | Not Yet Recruiting

• 1 other identifier: Soh-Med-26-5-7MS
• Study Type: observational
• Target: 360
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates corneal epithelial thickness using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. It aims to assess the relationship between epithelial thickness patterns and different types of refractive errors.

Conditions

Myopia; Hyperopia; Astigmatism; Emmetropia

Keywords

Corneal epithelial thickness, AS-OCT, anterior segment optical coherence tomography, refractive errors, myopia, hyperopia, astigmatism, cornea

Outcome Measures

Primary Outcomes (1)

• Measurement of corneal epithelial thickness using AS-OCT

  Corneal epithelial thickness will be measured using anterior segment optical coherence tomography (AS-OCT). Measurements will include central and regional epithelial thickness values in microns in patients with different refractive errors.

  At baseline during a single study visit when participants undergo AS-OCT examination.

Secondary Outcomes (4)

• Comparison of epithelial thickness between myopic and hyperopic eyes

  At baseline (single visit)

• Comparison of epithelial thickness in eyes with and without astigmatism

  At baseline (single visit)

• Corneal epithelial thickness asymmetry across corneal regions and inter-eye comparison

  At baseline (single visit)

• Comparison of epithelial thickness in low and high refractive errors

  At baseline (single visit)

Study Arms (1)

All Participants

All participants diagnosed with refractive errors (myopia, hyperopia, astigmatism) and emmetropia will be included in the study. All subjects will undergo anterior segment optical coherence tomography (AS-OCT) for corneal epithelial thickness mapping. Participants will then be analyzed according to their refractive status.

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult participants (≥18 years) with refractive errors, including myopia, hyperopia, and astigmatism, as well as emmetropic subjects, recruited from the Ophthalmology Department and undergoing anterior segment optical coherence tomography (AS-OCT) examination.

You may qualify if:

• Age ≥ 18 years-
• Patients diagnosed with myopia or hyperopia by refraction
• Clear cornea with no evidence of corneal pathology
• Ability to undergo reliable anterior segment imaging

You may not qualify if:

• Inability to fixate or follow instructions
• Family history of keratoconus
• Glaucoma,Cataract
• Previous ocular surgery including refractive surgery
• Keratoconus or suspected corneal ectasia
• Corneal opacities or scars
• Contact lens wear within the last two weeks
• Ocular trauma
• systemic disease affecting the cornea ( Such as diabetes)

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University Hospital

Sohag, Sohag Governorate, 82524, Egypt

Location

MeSH Terms

Conditions

Myopia; Hyperopia; Astigmatism; Refractive Errors; Corneal Diseases

Condition Hierarchy (Ancestors)

Eye Diseases

Study Officials

• Engy Mohamed Mostafa, Professor

  Department of Ophthalmology, Faculty of Medicine, Sohag University

  PRINCIPAL INVESTIGATOR

• Amin Abu-Ali Hassan, Assistant Professor

  Department of Ophthalmology, Faculty of Medicine, Sohag University

  STUDY DIRECTOR

• Yasmeen Gamal Abd-El latif, Lecturer

  Department of Ophthalmology, Faculty of Medicine, Sohag University

  STUDY DIRECTOR

Central Study Contacts

Merna romany loza, MBBCh, Ophthalmology Resident

CONTACT

01275800331; mernaromany54@yahoo.com

Engy Mohamed Mostafa, Professor

CONTACT

01005643587; Engymostafa@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Sub-investigator(resident)

Study Record Dates

• First Submitted: June 9, 2026
• First Posted: June 15, 2026
• Study Start (Estimated): July 1, 2026
• Primary Completion (Estimated): May 1, 2027
• Study Completion (Estimated): May 1, 2027
• Last Updated: June 15, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)