Comparative Effects of Neurodynamic Stretch and Myofascial Pain Release in Polycystic Ovarian Syndrome.

NCT07645014 | Recruiting

• 1 other identifier: REC/PCR & AHS/25/0515
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

The study will be a non-blinded randomized controlled trial, consisting of two groups. Non-probability Convenience sampling will be used to recruit participants who will meet the inclusion criteria. Group allocation will be performed using the sealed envelope method to ensure randomization of participants into experimental and control groups. The sample size will be 38 (19 in each group). Group A will receive neurodynamic stretches while Group B will receive myofascial pain release technique.

Conditions

Polycystic Ovarian Syndrome

Keywords

Dysmenorrhea; Myofascial pain release Neurodynamic stretch; Polycystic ovarian syndrome; Quality of sleep; Stress

Outcome Measures

Primary Outcomes (3)

• Mc Gill Questionnaire

  The short-form McGill Pain Questionnaire (SF-MPQ) is a shorter version of the original MPQ, and was developed later in 1987.The pain rating index has 2 subscales: * Sensory subscale with 11 words, and * Affective subscale with 4 words from the original MPQ. These words or items are rated on an intensity scale as 0 = none, 1 = mild, 2 = moderate and 3 = severe. Version includes 7 additional symptoms related to neuropathic pain, for a total of 22 items with 0-10 numerical response options. The reliability of the tool was measured using Cronbach's alpha value, and it was found to be 0.91

  6 weeks

• WaLIDD Score

  The WaLIDD score, or Working ability, Location, Intensity, Days of pain, Dysmenorrhea score, is a tool used to assess and diagnose dysmenorrhea (menstrual cramps) and predict the likelihood of needing medical leave. It's a self-report scale where individuals rate their experience of dysmenorrhea based on four key aspects: pain location, pain range, duration of pain, and disability. The total score, ranging from 0 to 12, categorizes the severity of dysmenorrhea: 0 indicates no dysmenorrhea, 1-4 is mild, 5-7 is moderate, and 8-12 is severe. The reliability of the tool was measured using Cronbach's alpha value, and it was found to be 0.88.

  6 weeks

• PSQI Scale

  The Pittsburgh Sleep Quality Index (PSQI) is a widely used self-report questionnaire that assesses sleep quality over a one-month time interval. Each component score of the PSQI ranges from 0 to 3, with 3 indicating the greatest dysfunction or disturbance. The seven component scores are then summed to obtain a global PSQI score, which ranges from 0 to 21. Higher scores indicate poorer sleep quality, with a score greater than 5 suggesting significant sleep difficulties. The reliability of the tool was measured using Cronbach's alpha value, and it was found to be 0.83.

  6 weeks

Study Arms (2)

Neurodynamic stretches

ACTIVE COMPARATOR

Group A will receive neurodynamic stretches which includes abdominal stretches, calf stretches, hamstring stretches.

Other: Neurodynamic stretches

myofascial pain release technique

EXPERIMENTAL

Group B will receive myofascial pain release technique.

Other: myofascial pain release technique Interventions:

Interventions

Neurodynamic stretches OTHER

Participants will receive neurodynamic mobilization techniques focused on improving the mobility of the lumbosacral plexus and peripheral nerves. Week 1-2: * Introduction to neural sliders only. * Techniques: Supine straight leg raise (SLR) with ankle dorsiflexion, femoral nerve glide, and seated slump position. Frequency: 3 sets of 10 repetitions per nerve. Emphasis: Gentle, pain-free movements with diaphragmatic breathing Week 3-4: Progression to sliders + tensioners. • Techniques: Dynamic slump with tensioning, prone femoral tensioner. Repetitions: 2 sets of 5-7 controlled repetitions. Emphasis: Slight neural load increase while ensuring patient comfort. Week 5-6: * Continuation of advanced techniques with full-range tensioners. * Integration of posture correction and relaxation techniques. Emphasis: Endurance and mobility with symptom monitoring. Frequency: 3 sessions per week Duration: 20-30 minutes per session Total duration: 6 weeks

Neurodynamic stretches

myofascial pain release technique Interventions: OTHER

Participants will receive myofascial release therapy aimed at relieving fascial tightness, trigger points, and muscle stiffness in the abdominal, pelvic, and lumbar regions. Week 1-2: * Light pressure applied to abdominal fascia and lower back region. * Techniques: Cross-hand fascial release, skin rolling, and gentle pressure on trigger points. Each hold: 90-120 seconds per site. Week 3-4: * Increased pressure depth depending on patient tolerance. * Targeting deeper pelvic structures and sacroiliac area. * Use of foam roller introduced for myofascial self-release. Week 5-6: * Maintenance of deeper myofascial techniques with added pelvic stretching. * Integration of postural awareness and relaxation breathing. * Focus on combining manual release with functional mobility. Frequency: 3 sessions per week Duration: 20-30 minutes per session Total duration: 6 weeks

myofascial pain release technique

Eligibility Criteria

• Age: 18 Years - 35 Years
• Gender Eligibility Details: Diagnosed cases of PCOS with irregular periods until 3 months and Presence of dysmenorrhea (Check WaLIDD Questionnaire)
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18-35 years
• Diagnosed cases of PCOS
• Irregular periods until 3 months.
• Presence of dysmenorrhea (Check WaLIDD Questionnaire)
• BMI
• Age of Menarche (13 years)

You may not qualify if:

• History of endocrine disorders
• Endometriosis
• Tumour
• Any major surgeries
• Marital Status (un married)

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Shaikh Zayed Hospital

Lahore, Punjab Province, 54000, Pakistan

RECRUITING

Related Publications (5)

• Nunez de Arenas-Arroyo S, Martinez-Vizcaino V, Torres-Costoso A, Reina-Gutierrez S, Bizzozero-Peroni B, Cavero-Redondo I. Immediate and short-term effects of neurodynamic techniques on hamstring flexibility: A systematic review with meta-analysis. PLoS One. 2025 Feb 6;20(2):e0318671. doi: 10.1371/journal.pone.0318671. eCollection 2025.

  PMID: 39913497 BACKGROUND

• Lv Y, Yin Y. A Review of the Application of Myofascial Release Therapy in the Treatment of Diseases. J Multidiscip Healthc. 2024 Sep 26;17:4507-4517. doi: 10.2147/JMDH.S481706. eCollection 2024.

  PMID: 39351042 BACKGROUND

• Haider R, Geetha K. Das,(2024), Menstrual Problems: Menorrhagia and Primary Dysmenorrhagia. Biomedical Research and Clinical Trials.;3(1).

  BACKGROUND

• Wang C, Liu L, Bai X. Knowledge Mapping of Primary Dysmenorrhea: Hotspots, Knowledge Structure, and Theme Trends. J Pain Res. 2023 Oct 27;16:3613-3624. doi: 10.2147/JPR.S435236. eCollection 2023.

  PMID: 37915863 BACKGROUND

• Teede HJ, Neven ACH, Pena A. Evolution of evidence-based diagnostic criteria in adolescents with polycystic ovary syndrome. Hum Reprod. 2024 May 2;39(5):876-877. doi: 10.1093/humrep/deae050. No abstract available.

  PMID: 38514447 BACKGROUND

MeSH Terms

Conditions

Polycystic Ovary Syndrome; Dysmenorrhea; Sleep Initiation and Maintenance Disorders

Condition Hierarchy (Ancestors)

Ovarian Cysts; Cysts; Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Gonadal Disorders; Endocrine System Diseases; Menstruation Disturbances; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pelvic Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Mental Disorders

Study Officials

• Hafiza Iqra Rubab, MSWHPT

  Riphah International University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Imran Amjad, PhD

CONTACT

03324390125; imran.amjad@riphah.edu.pk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 8, 2026
• First Posted: June 12, 2026
• Study Start: October 1, 2025
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: June 12, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)