Clinical and Jaw Tracking Assessment Following Intra-articular Injection of PRP and HA in TMJ Disc Displacement With Reduction

NCT07643402 | Completed

• 1 other identifier: MS.25.03.12
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

Assessment of intra-articular injection of hyaluronic acid and prp within TMJ using the Zebris jaw tracking device as an objective method

Conditions

Disc Displacement With Reduction

Keywords

tmj; disc displacement with reduction; jaw tracking; hyaluronic acid; prp

Outcome Measures

Primary Outcomes (1)

• Mandibular movements assessed using the zebris JMA

  changes in mandibular movements assessed using the Zebris Jaw Motion Analyzer (JMA) system following treatment

  Baseline, 1month

Secondary Outcomes (3)

• Maximum interincisal opening (MIO)

  Baseline, 1 week, 1 month, 3 months,6 months

• Pain intensity assessed using the Visual Analog Scale (VAS)

  baseline, 1 week, 1 month, 3months, 6 months

• clicking sound

  Baseline, 6 months

Study Arms (1)

Hyaluronic acid + PRP

EXPERIMENTAL

patients with disc displacement with reduction will undergo intra-articular injection with hyaluronic acid and prp

Combination Product: Hyaluronic Acid (HA) and Platelet rich plasma

Interventions

Hyaluronic Acid (HA) and Platelet rich plasma COMBINATION_PRODUCT

A combination of Autologous Platelet-Rich Plasma prepared from the patient's blood and hyaluronic acid injected intra-articularly

Hyaluronic acid + PRP

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• The patients' ages range from 18 to 45.
• Patients experienced clicking sounds, painful joints, and restricted mouth opening.
• Individuals whose MRI confirms a unilateral internal abnormality with reduction.
• A patient who did not respond to conservative treatment. 5 • The patient's capacity and willingness to finish the course of therapy and subsequent appointments.

You may not qualify if:

• A patient suffering from a connective tissue or inflammatory condition.
• A patient who has had TMJ surgery in the past.
• A history of injecting any kind of material into the target TMJ.
• Drug allergy history.
• A patient who has previously had fibrous or bony adhesion.
• A patient experiencing psychological issues.

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Faculty of Dentistry, Mansoura university

Al Mansurah, Dakahlia Governorate, 35516, Egypt

Location

MeSH Terms

Conditions

Temporomandibular Joint Disorders; Insomnia, Fatal Familial

Interventions

Hyaluronic Acid

Condition Hierarchy (Ancestors)

Craniomandibular Disorders; Mandibular Diseases; Jaw Diseases; Musculoskeletal Diseases; Joint Diseases; Muscular Diseases; Stomatognathic Diseases; Prion Diseases; Central Nervous System Infections; Infections; Central Nervous System Diseases; Nervous System Diseases; Neurodegenerative Diseases; Sleep Initiation and Maintenance Disorders; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders

Intervention Hierarchy (Ancestors)

Glycosaminoglycans; Polysaccharides; Carbohydrates

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Oral and maxillofacial master student

Study Record Dates

• First Submitted: June 7, 2026
• First Posted: June 11, 2026
• Study Start: July 1, 2025
• Primary Completion: November 15, 2025
• Study Completion: May 5, 2026
• Last Updated: June 11, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)