Diagnostic Performance of Serum Calprotectin in Acute Appendicitis

NCT07643142 | Completed

• 1 other identifier: FSMEAH-KAEK-2015-53
• Study Type: observational
• Target: 74
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study evaluated the diagnostic performance of serum calprotectin in patients presenting with acute abdominal pain and suspected acute appendicitis. Patients with histopathologically confirmed acute appendicitis were compared with patients diagnosed with nonspecific abdominal pain. Serum calprotectin levels were analyzed and compared with conventional inflammatory markers and the Alvarado score to assess their diagnostic value in acute appendicitis.

Conditions

Acute Appendicitis; Abdominal Pain

Keywords

serum calprotectin; acute appendicitis; diagnostic biomarker; inflammatory marker

Outcome Measures

Primary Outcomes (1)

• Diagnostic accuracy of serum calprotectin for acute appendicitis

  Comparison of serum calprotectin levels between patients with acute appendicitis and nonspecific abdominal pain.

  At admission to the emergency department

Study Arms (2)

Acute Appendicitis

Patients with histopathologically confirmed acute appendicitis who underwent appendectomy.

Diagnostic Test: Serum Calprotectin Measurement

Non-specific Abdominal Pain

Patients presenting with nonspecific abdominal pain without evidence of appendicitis during follow-up.

Diagnostic Test: Serum Calprotectin Measurement

Interventions

Serum Calprotectin Measurement DIAGNOSTIC_TEST

Measurement of serum calprotectin levels using ELISA for diagnostic evaluation of acute appendicitis.

Acute Appendicitis; Non-specific Abdominal Pain

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients presenting to the emergency department with acute abdominal pain and suspected acute appendicitis. Participants were divided into two groups: patients diagnosed with acute appendicitis and patients with non-specific abdominal pain.

You may qualify if:

• Age between 18 and 75 years
• Presentation to the emergency department with acute abdominal pain and suspected acute appendicitis
• Willingness to participate and provide informed consent

You may not qualify if:

• Previous abdominal surgery
• Chronic inflammatory or autoimmune disease
• Active infection other than suspected appendicitis
• Use of systemic anti-inflammatory or immunosuppressive therapy
• Pregnancy
• Incomplete clinical or laboratory data

Sponsors & Collaborators

• Fatih Sultan Mehmet Training and Research Hospital: lead

Study Sites (1)

Fatih Sultan Mehmet Training and Research Hospital

Istanbul, ATASEHIR, 34752, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Appendicitis; Abdominal Pain

Condition Hierarchy (Ancestors)

Intraabdominal Infections; Infections; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Cecal Diseases; Intestinal Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Signs and Symptoms, Digestive

Study Officials

• fatih kilic, MD

  Fatih Sultan Mehmet Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 2, 2026
• First Posted: June 11, 2026
• Study Start: December 13, 2015
• Primary Completion: April 19, 2016
• Study Completion: April 21, 2016
• Last Updated: June 11, 2026

Record last verified: 2026-06

Locations

TU (1)