Home-based Vision Rehabilitation Guided by Brain Imaging

NCT07635329 | Recruiting

• 2 other identifiers: STUDY0001031426CDA1590827
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss. Using a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.

Conditions

Visual Field Defect; Hemianopia Homonymous; Cortical Blindness; Brain Tumor; Visual Field Defect, Peripheral; Stroke; Quadrantanopia; Visual Field Loss; Traumatic Brain Injury

Keywords

neuroplasticity; stroke; vision; TBI; brain tumor

Outcome Measures

Primary Outcomes (2)

• Change in high-level perceptual discrimination performance

  Change in performance on an online computerized high-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy.

  Week 2-4 or Week 7-9 of the study (depending on the order)

• Change in low-level perceptual discrimination performance

  Change in performance on an online computerized low-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy.

  Week 2-4 or Week 7-9 of the study (depending on the order)

Study Arms (2)

Perceptual learning-based training using high-level visual stimuli

EXPERIMENTAL

A 3 week at-home online perceptual learning-based training using high-level visual stimuli.

Behavioral: High-level perceptual learning-based training

Perceptual learning-based training using low-level visual stimuli

ACTIVE COMPARATOR

A 3 week at-home online perceptual learning-based training using low-level visual stimuli.

Behavioral: Low-level perceptual learning-based training

Interventions

Low-level perceptual learning-based training BEHAVIORAL

behavioral intervention consisting of repeated computerized visual discrimination tasks targeting low-level visual processing

Perceptual learning-based training using low-level visual stimuli

High-level perceptual learning-based training BEHAVIORAL

Behavioral intervention consisting of repeated computerized visual discrimination tasks targeting higher-order visual processing

Perceptual learning-based training using high-level visual stimuli

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• At least 18 years of age.
• Capable of providing informed consent and complying with study procedures.
• Unilateral or bilateral focal brain damage causing visual field loss.
• At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.
• Eligible for MRI based on standard safety screening.

You may not qualify if:

• Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation.
• Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.
• Ocular disease or disorder.

Sponsors & Collaborators

• Georgetown University: lead
• American Heart Association: collaborator

Study Sites (1)

Georgetown University Medical Center

Washington D.C., District of Columbia, 20057, United States

RECRUITING

MeSH Terms

Conditions

Stroke; Hemianopsia; Blindness, Cortical; Brain Injuries, Traumatic; Brain Neoplasms

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Vision Disorders; Sensation Disorders; Neurologic Manifestations; Blindness; Eye Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Brain Injuries; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries; Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Neoplasms

Central Study Contacts

Tina Liu, PhD

CONTACT

2027849920; tina.liu@georgetown.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Neurology

Model Details: Study Procedures Week 1: Pre-intervention visual assessment and functional magnetic resonance imaging (fMRI) scan (in-person study visit). Weeks 2-4: Participants complete at-home, online perceptual learning training using either low-level or high-level visual stimuli. End of Week 4: Online assessment to evaluate the spatial transfer of training effects. Weeks 5-6: Washout period to minimize potential carryover effects. Weeks 7-9: Participants complete the alternate at-home, online perceptual learning training condition (low-level or high-level visual stimuli). End of Week 9: Second online assessment to evaluate the spatial transfer of training effects. Week 10 (Final Visit): Post-intervention visual assessment and fMRI scan (in-person study visit). Approximately Week 24: Follow-up visual assessment and fMRI scan (in-person study visit). The timing of study visits and training sessions may be adjusted as needed to accommodate participants' health status, scheduling needs, or o

Study Record Dates

• First Submitted: June 3, 2026
• First Posted: June 9, 2026
• Study Start (Estimated): July 1, 2026
• Primary Completion (Estimated): March 31, 2030
• Study Completion (Estimated): March 31, 2030
• Last Updated: June 9, 2026

Record last verified: 2026-06

Locations

US (1)