Prediction of Myocardial Injury After Non-Cardiac Surgery in Urologic Cancer Patients

NCT07634666 | Recruiting DMC

• 2 other identifiers: URO-MINS-012026AN0157
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective multicenter observational study aims to evaluate the predictive value of artificial intelligence-based analysis of preoperative 12-lead electrocardiography for myocardial injury after non-cardiac surgery (MINS) and major adverse cardiovascular events (MACE) within 30 days after surgery in patients undergoing non-cardiac surgery for urologic cancer.

Conditions

Urologic Cancer; Major Adverse Cardiovascular Events (MACE); Myocardial Injury After Non-cardiac Surgery

Keywords

Artificial Intelligence; Electrocardiography; Myocardial Injury After Non-cardiac Surgery; Major Adverse Cardiovascular Events; Perioperative Cardiovascular Risk; Urologic Cancer

Outcome Measures

Primary Outcomes (1)

• Number of Participants with Myocardial Injury After Non-Cardiac Surgery (MINS)

  Myocardial injury after non-cardiac surgery (MINS), defined as an elevation of fourth-generation cardiac troponin T measured on the day of surgery, postoperative day 1, and postoperative day 2 (within 3 days after surgery)

  Intraoperative day and postoperative days 1-2 (within 3 days after surgery)

Secondary Outcomes (1)

• Number of Participants with 30-Day Major Adverse Cardiovascular Events (MACE)

  Within 30 days after surgery

Study Arms (1)

Urologic cancer patients undergoing major non-cardiac surgery

Patients with urologic malignancy scheduled for major non-cardiac surgery will be prospectively enrolled and observed for perioperative myocardial injury and related outcomes.

Other: No intervention assigned

Interventions

No intervention assigned OTHER

This is a prospective observational study. No interventions are administered. Participants are followed for the development of myocardial injury after major non-cardiac surgery.

Urologic cancer patients undergoing major non-cardiac surgery

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 60 years or older scheduled for major non-cardiac surgery under general anesthesia due to urologic malignancy (e.g., radical prostatectomy, radical nephrectomy, partial nephrectomy) will be prospectively enrolled from participating centers. All eligible patients who provide informed consent and meet inclusion criteria will be followed for perioperative myocardial injury and 30-day cardiovascular outcomes.

You may qualify if:

• Age ≥ 60 years
• Patients scheduled for major non-cardiac surgery under general anesthesia due to urologic cancer (e.g., radical prostatectomy, radical nephrectomy, partial nephrectomy)
• Patients who undergo preoperative standard 12-lead electrocardiography
• Patients classified as having intermediate or higher surgical risk
• Patients who can be followed for at least 30 days postoperatively
• Patients who voluntarily provide written informed consent to participate in this study

You may not qualify if:

• History of major adverse cardiovascular events (MACE) within 6 months prior to surgery
• Inability to obtain essential clinical information required for study participation and follow-up
• Patients who are not hospitalized after surgery
• Individuals deemed inappropriate for participation in the study by the investigator due to legal or psychiatric reasons

Sponsors & Collaborators

• Korea University Anam Hospital: lead
• Medical AI Co., Ltd: collaborator
• The Catholic University of Korea: collaborator
• Keimyung University Dongsan Medical Center: collaborator

Study Sites (1)

Seoul St. Mary's Hospital, The Catholic University of Korea

Seoul, 06591, South Korea

RECRUITING

Related Publications (4)

• Xie X, Hu W, Fan X, Chen H, Tang M. Interactions Between Phosphorus, Zinc, and Iron Homeostasis in Nonmycorrhizal and Mycorrhizal Plants. Front Plant Sci. 2019 Sep 26;10:1172. doi: 10.3389/fpls.2019.01172. eCollection 2019.

  PMID: 31616454 RESULT

• Matsubara M, Muraki Y, Suzuki H, Hatano N, Muraki K. Critical amino acid residues regulating TRPA1 Zn2+ response: A comparative study across species. J Biol Chem. 2024 Jun;300(6):107302. doi: 10.1016/j.jbc.2024.107302. Epub 2024 Apr 18.

  PMID: 38642892 RESULT

• Halvorsen S, Mehilli J, Cassese S, Hall TS, Abdelhamid M, Barbato E, De Hert S, de Laval I, Geisler T, Hinterbuchner L, Ibanez B, Lenarczyk R, Mansmann UR, McGreavy P, Mueller C, Muneretto C, Niessner A, Potpara TS, Ristic A, Sade LE, Schirmer H, Schupke S, Sillesen H, Skulstad H, Torracca L, Tutarel O, Van Der Meer P, Wojakowski W, Zacharowski K; ESC Scientific Document Group. 2022 ESC Guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery. Eur Heart J. 2022 Oct 14;43(39):3826-3924. doi: 10.1093/eurheartj/ehac270. No abstract available.

  PMID: 36017553 RESULT

• Zhong L, Yan K, Liu C, Xue J, Wu L, Yin F. Clinical reasoning: a young man with reversible paralysis, cerebral white matter lesions, and peripheral neuropathy. Neurology. 2012 Aug 21;79(8):e70-2. doi: 10.1212/WNL.0b013e3182661eca. No abstract available.

  PMID: 22915180 RESULT

MeSH Terms

Conditions

Urologic Neoplasms

Condition Hierarchy (Ancestors)

Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Urologic Diseases

Study Officials

• Dong Hyuck Cho, MD, PhD

  Korea University Anam Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Dong Hyuck Cho, MD, PhD

CONTACT

+82-2-920-5448; why012@gmail.com

Jong-Chan Youn, MD, PhD

CONTACT

+82-2-2258-6145; jong.chan.youn@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: June 3, 2026
• First Posted: June 9, 2026
• Study Start: July 15, 2026
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: July 22, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)