Triggered Imaging in Glioblastoma Based on Clinical Outcome Evaluation Compared to Routine: a Feasibility Study

NCT07634575 | Enrolling By Invitation

• 1 other identifier: KCH22-151
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This is a feasibility randomized controlled trial comparing triggered imaging based on patient symptom self-reporting and performance-based measures with the existing imaging schedule.

Conditions

Glioblastoma

Keywords

imaging

Outcome Measures

Primary Outcomes (2)

• The primary outcomes are: - Number of patients willing to self-report symptoms on an online app - Number of patients willing to undertake cognitive testing - Number of complete symptom questionnaires and assessments - Number of fast track MRI

  From enrollment up to 12 months

• The primary outcomes are: - Number of patients willing to self-report symptoms on an online app - Number of complete symptom questionnaires and assessments - Number of fast track MRI

  From enrollment up to 12 months

Study Arms (1)

Diagnostic Test: triggered imaging Description: triggered imaging for symptoms as opposed to routine

EXPERIMENTAL

1

Diagnostic Test: triggered imaging

Interventions

triggered imaging DIAGNOSTIC_TEST

triggered imaging for symptoms as opposed to routine interval imaging

Diagnostic Test: triggered imaging Description: triggered imaging for symptoms as opposed to routine

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• i. Newly diagnosed glioblastoma (WHO grade IV) ii. Planned to undergo the Stupp treatment regimen iii. Aged 18-70 iv. To be treated at KCH and GSTT v. No MRI contraindications vi. Patients with internet access and an e-mail account

You may not qualify if:

• i. Uncertainty of diagnosis ii. Deviation from the standard Stupp regimen iii. Patients participating in another interventional study iv. Unable to read and comprehend English language text v. Lack capacity at point of consent vi. WHO Performance status \> 3 (Karnofsky score \< 30)

Sponsors & Collaborators

• King's College Hospital NHS Trust: lead

Study Sites (1)

KCH

London, United Kingdom

Location

MeSH Terms

Conditions

Glioblastoma

Interventions

Cardiac-Gated Imaging Techniques

Condition Hierarchy (Ancestors)

Astrocytoma; Glioma; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 17, 2026
• First Posted: June 9, 2026
• Study Start: April 1, 2025
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: June 9, 2026

Record last verified: 2026-05

Locations

GB (1)