A Study to Assess the Efficacy of Public Health Campaigns in Reducing Lead Exposure

NCT07632937 | Not Yet Recruiting DMC

• 1 other identifier: InternationalHealth2026
• Study Type: interventional
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical trial aims to evaluate the effectiveness of targeted public health campaigns in reducing lead exposure among adults living in urban communities with known environmental lead hazards. Lead exposure remains a significant public health concern, particularly in older urban neighborhoods with aging infrastructure and legacy contamination. Despite existing regulations and remediation efforts, many communities continue to experience elevated blood lead levels, especially among vulnerable populations. The study will compare the impact of an intensive, multi-modal public health campaign-featuring community workshops, educational materials, and home intervention resources-against standard municipal information dissemination. By assessing changes in blood lead levels and lead-related knowledge, attitudes, and behaviors over a 12-month period, the trial seeks to determine whether enhanced public health outreach can more effectively reduce lead exposure and promote safer practices. The findings will inform future strategies for community-based environmental health interventions.

Conditions

Lead Poisoning; Environmental Exposure

Keywords

lead poisoning; lead

Outcome Measures

Primary Outcomes (1)

• Change in Blood Lead Level

  Mean change in venous blood lead concentration (μg/dL) among index household participants from baseline to 12 months.

  Through study completion, an average of 1 year

Secondary Outcomes (4)

• Change in Lead-Related Knowledge

  Through study completion, an average of 1 year

• Adoption of Lead-Safe Practices

  Through study completion, an average of 1 year

• Environmental Lead Levels in Home

  Through study completion, an average of 1 year

• Incidence of New Elevated Blood Lead Cases

  Through study completion, an average of 1 year

Study Arms (2)

Intensive Public Health Campaign

EXPERIMENTAL

Participants receive an intensive, multi-modal public health campaign including workshops, educational materials, lead-safe cleaning kits, and home visits by health educators.

Behavioral: Intensive Public Health Campaign

Standard Information Dissemination

ACTIVE COMPARATOR

Participants receive the standard municipal information package on lead exposure prevention currently distributed by city health departments.

Behavioral: Standard Information Dissemination

Interventions

Intensive Public Health Campaign BEHAVIORAL

A comprehensive intervention including: (1) three interactive community workshops on lead risks and prevention, (2) distribution of tailored educational materials, (3) provision of lead-safe cleaning kits (HEPA vacuums, cleaning supplies), and (4) two home visits by trained health educators to reinforce messages and assess household practices. Delivered over a 12-month period.

Intensive Public Health Campaign

Standard Information Dissemination BEHAVIORAL

Provision of standard municipal information on lead exposure prevention, including pamphlets and website links, as currently distributed by public health authorities. No additional workshops or home visits provided.

Standard Information Dissemination

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Resident of selected urban neighborhoods with documented environmental lead risk
• Household includes at least one adult aged 18-75 years willing to participate
• Willing to provide informed consent
• Willing to allow home visits and blood sampling
• Able to understand study procedures and interventions

You may not qualify if:

• Planning to relocate from the area within the next 12 months
• Household member with a known diagnosis of severe anemia or bleeding disorder
• Participation in another intervention study targeting lead exposure in the past 12 months
• Inability or unwillingness to comply with study procedures
• Household with known ongoing lead remediation efforts during the study period
• Pregnant women (due to additional ethical considerations for blood sampling)

Sponsors & Collaborators

• International Health Strategies LLC: lead

Study Sites (1)

Philadelphia City Center

Philadelphia, Pennsylvania, 19107, United States

Location

MeSH Terms

Conditions

Lead Poisoning

Condition Hierarchy (Ancestors)

Heavy Metal Poisoning; Poisoning; Chemically-Induced Disorders

Study Officials

• Brian Goldstein, MD MPH

  International Health Strategies LLC

  STUDY DIRECTOR

Central Study Contacts

Brian Goldstein, MD MPH

CONTACT

215-287-7688; Brian.Goldstein@intlhealthstrategies.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Open-label due to the nature of behavioral and educational interventions.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Model Details: Parallel assignment of neighborhoods to either intensive public health campaign or standard information dissemination.

Study Record Dates

• First Submitted: May 27, 2026
• First Posted: June 8, 2026
• Study Start (Estimated): October 31, 2026
• Primary Completion (Estimated): November 1, 2028
• Study Completion (Estimated): November 1, 2028
• Last Updated: June 8, 2026

Record last verified: 2026-06

Locations

US (1)