Customized Approaches for Evaluating and Reducing Chemical Exposures From Home Building Materials

NCT05416281 | Completed

• 1 other identifier: Pro00110402
• Study Type: interventional
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

This project will evaluate new approaches to quantify and reduce chemical exposures from common building materials, with an emphasis on plastic additives, pesticides, flame retardants and lead in addition to other environmental contaminants. The objective of this project is to develop methods to quantify and reduce chemical exposures from the home environment using approaches that are adaptable and customizable to individuals and households. To achieve this goal investigators will: 1) Identify the types of building materials and housing characteristics associated with higher levels of exposure to different classes of contaminants; 2) Assess the effectiveness of a simple robotic vacuuming intervention for reducing exposure to a range of indoor contaminants; and 3) Evaluate a new wearable silicone wristband for monitoring exposure to lead and other metals.

Conditions

Environmental Exposure

Keywords

Environmental Exposure; Vacuum

Outcome Measures

Primary Outcomes (1)

• Change in Environmental Chemical Exposures

  Change in the mass of environmental chemicals on silicone wristbands will be evaluated after an 8-week vacuum intervention.

  Participation will last through study completion, an average of 9 weeks

Study Arms (2)

Robotic Vacuum Intervention

EXPERIMENTAL

This will include a home visit for environmental assessment AND a robotic vacuum intervention. Silicone wristbands will be used to evaluate exposure before and after a cleaning intervention.

Other: Robotic Vacuum

No Intervention

NO INTERVENTION

This will include a home visit for environmental assessment.

Interventions

Robotic Vacuum OTHER

Participants will be provided with a Roomba iRobot vacuum and will be asked to use the vacuum in their home for 8 weeks. Exposure to environmental exposures will be evaluated before and after the intervention using silicone wristbands.

Robotic Vacuum Intervention

Eligibility Criteria

• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants enrolled in Project HOPE 1000, a pregnancy cohort study at Duke University Medical Center.
• Any enrolled HOPE 1000 participants planning to remain in their homes for at least the following 12 weeks will be eligible for our sub-studies.

You may not qualify if:

• Individuals not planning to remain in their homes for at least 12 weeks.
• Those not able to communicate in fluent English will be excluded.

Sponsors & Collaborators

• Duke University: lead

Study Sites (1)

Duke University

Durham, North Carolina, 27708, United States

Location

Study Officials

• Heather Stapleton, PhD

  Duke University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Exposure will be evaluated before vacuuming and again after 8 weeks of vacuuming.

Study Record Dates

• First Submitted: June 5, 2022
• First Posted: June 13, 2022
• Study Start: August 11, 2022
• Primary Completion: October 11, 2024
• Study Completion: October 11, 2024
• Last Updated: November 18, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)