Association Between Trendelenburg Sign and Lumbar MRI Abnormalities

NCT07629466 | Not Yet Recruiting

• 1 other identifier: BAU-FTR-2026-07/04
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The Trendelenburg sign is a common clinical finding indicating hip abductor dysfunction and altered pelvic stability. The relationship between the Trendelenburg sign, spinopelvic biomechanics, hip muscle strength, and lumbar magnetic resonance imaging (MRI) abnormalities remains insufficiently understood. This study aims to investigate the association between Trendelenburg sign positivity and lumbar MRI findings, including facet arthropathy, ligamentum flavum hypertrophy, multifidus muscle morphology, and psoas muscle characteristics, as well as spinopelvic biomechanical parameters and hip abductor muscle strength.

Conditions

Facet Joint Arthropathy; Lower Back Pain

Outcome Measures

Primary Outcomes (1)

• Presence and Severity of Lumbar Facet Joint Arthropathy

  Assessment of the presence and severity of lumbar facet joint arthropathy on magnetic resonance imaging (MRI) and its association with Trendelenburg sign positivity.

  Baseline

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults aged 18-65 years with low back pain and available lumbar MRI scans obtained within the previous 12 months. Participants will undergo clinical assessment for Trendelenburg sign and hip function, and lumbar MRI evaluation for degenerative changes.

You may qualify if:

• Age between 18 and 65 years.
• Patients who have previously presented to the clinic with a complaint of low back pain.
• Willingness and ability to provide written informed consent for participation in the study.
• Availability of lumbar MRI images obtained within the previous 12 months and accessible for evaluation.

You may not qualify if:

• Presence of red flag conditions associated with low back pain, including malignancy, infection, acute trauma, or significant neurological deficits.
• History of lumbar spine surgery.
• Structural spinal anomalies such as sacralization or lumbarization.
• Spinal deformities, including scoliosis.
• Rheumatologic diseases affecting the spine (e.g., axial spondyloarthritis).
• Significant radiculopathy or advanced neurological deficits, and the presence of extruded or sequestrated lumbar disc herniation.
• Clinically significant lumbar spinal stenosis.
• Spondylolysis and/or spondylolisthesis.
• Acute vertebral fracture, compression fracture, or recent fracture associated with severe osteoporosis.
• Hip or pelvic conditions that may directly influence the Trendelenburg sign, including: History of hip arthroplasty or hip surgery, advanced hip osteoarthritis, residual deformity following lower-extremity fracture, significant leg length discrepancy (\>2 cm).
• Systemic or neuromuscular disorders, including multiple sclerosis, myopathies, amyotrophic lateral sclerosis (ALS), stroke, or peripheral neuropathies.
• Pregnancy.
• Severe knee or ankle pathology or other conditions causing substantial gait impairment.

Sponsors & Collaborators

• Bahçeşehir University: lead

Study Sites (1)

Bahcesehir university

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Low Back Pain

Condition Hierarchy (Ancestors)

Back Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

zeynep Iyigun, Prof. MD

CONTACT

+905056987368; zeynep.iyigun@bau.edu.tr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: prof., MD

Study Record Dates

• First Submitted: June 1, 2026
• First Posted: June 5, 2026
• Study Start: June 4, 2026
• Primary Completion: August 25, 2026
• Study Completion (Estimated): October 10, 2026
• Last Updated: June 10, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)