Cerebral Connectivity and Metabolic Phenotype of Gliomas: Prospective Addition of DTI and Rs-fMRI to a Preoperative FDG PET Strategy, With Neuropsychological Correlates and Post-treatment Follow-up
GlioConnect
2 other identifiers
interventional
80
1 country
1
Brief Summary
The aim of this study is to determine whether the diffuse cerebral metabolic disturbances observed in glioblastoma are exclusively linked to the direct and indirect effects of tumor infiltration (particularly structural disconnection), or whether they also reflect a more global alteration of neurometabolic and neurovascular coupling mechanisms. This approach thus aims to better understand the pathophysiological basis of cognitive impairment in glioblastoma and to characterize the impact of the disease at the level of brain networks.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Sep 2026
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 28, 2026
CompletedFirst Posted
Study publicly available on registry
June 4, 2026
CompletedStudy Start
First participant enrolled
September 15, 2026
ExpectedPrimary Completion
Last participant's last visit for primary outcome
September 15, 2030
Study Completion
Last participant's last visit for all outcomes
September 15, 2030
June 4, 2026
June 1, 2026
4 years
May 28, 2026
June 3, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Correlation between cortical energy activity (FDG PET), axonal morphological connectivity (DTI - MRI), synchronous neuronal activity (rs-fMRI), and preoperative neuropsychological performance before surgery
Before surgery
Secondary Outcomes (1)
correlation between cortical energy activity (FDG PET), axonal morphological connectivity (DTI - MRI), synchronous neuronal activity (rs-fMRI), and preoperative neuropsychological performance after surgery
After surgery, through the study, i.e. for a maximum of 2 years
Study Arms (1)
Patients with glioblastoma treated in the Department of Nuclear Medicine & Molecular Imaging
OTHERInterventions
fluorodeoxyglucose (Fluor18) (18F-FDG) PET/MRI with additional DTI and rs-fMRI sequences correlation with neuropsychological tests
Eligibility Criteria
You may qualify if:
- Adult patients
- Patients with glioblastoma
- Patients treated in the Nuclear Medicine \& Molecular Imaging Department of the Strauss Institute for PET/MRI scans for:
- Preoperative metabolic evaluation of a brain-expanding lesion
You may not qualify if:
- Contraindications to MRI
- Minor or incapacitated adult
- Patient deprived of liberty
- Patient under legal guardianship
- Patient unable to consent
- Pregnant or breastfeeding woman
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Institut public de cancérologie Strauss Europe
Strasbourg, 67033, France
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Izzie-Jacques NAMER, MD, PhD
Institut Public De Cancerologie Strauss Europe
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- OTHER
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 28, 2026
First Posted
June 4, 2026
Study Start (Estimated)
September 15, 2026
Primary Completion (Estimated)
September 15, 2030
Study Completion (Estimated)
September 15, 2030
Last Updated
June 4, 2026
Record last verified: 2026-06