Prospective Dynamic Cohort Study of Phenotypic Profiles in Patients With Chronic Obstructive Pulmonary Disease

NCT07627763 | Recruiting

• 1 other identifier: 2024-A00438-39 / COPD-BPCO 2
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 7

Brief Summary

This prospective, multicenter, real-world observational cohort study will describe phenotypic profiles, patient characteristics, and treatments in adults with stable chronic obstructive pulmonary disease (COPD). The profiles observed in the current cohort will be compared with those of patients recruited between 2005 and 2018 in the previous COPD-BPCO 1 cohort. Patients will be followed for at least 3 years as part of routine care, with no study-specific visit or treatment.

Conditions

COPD

Keywords

quality of life; dyspnea; pulmonary function; exacerbations; COPD; CART

Outcome Measures

Primary Outcomes (1)

• Identification and description of COPD phenotypic profiles

  COPD phenotypic subgroups will be defined using unsupervised clustering and described according to patient characteristics, treatments, pulmonary function, symptoms, exacerbations, clinically important deterioration, and mortality

  Baseline and up to 3 years

Secondary Outcomes (4)

• Comparison of phenotypic profiles with the previous COPD-BPCO 1 cohort

  Current profiles will be compared with those observed in the previous cohort recruited between 2005 and 2018.

• Prognosis of current patients compared with the previous cohort

  3 years

• Applicability of previously developed CART algorithms

  Through study completion, an average of 3 years

• Adverse events

  Through study completion, an average of 3 years

Study Arms (1)

Patients with stable COPD

Adults with stable COPD confirmed by post-bronchodilator FEV1/FVC \< 70%, recruited during routine pulmonology care

Other: Routine care / no study-specific intervention

Interventions

Routine care / no study-specific intervention OTHER

Patients will be managed according to usual care at the investigator's discretion. The study does not assign any treatment, medicinal product, or medical device.

Patients with stable COPD

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with stable COPD followed in French hospital pulmonology centers.

You may qualify if:

• Age 18 years or older.
• Stable COPD, defined as no exacerbation requiring treatment during the previous 4 weeks.
• Confirmed COPD diagnosis based on post-bronchodilator FEV1/FVC \< 70%

You may not qualify if:

• Main diagnosis of bronchiectasis, asthma, or any other significant respiratory disease.
• Patients under legal protection.
• Pregnant women.

Sponsors & Collaborators

• Initiatives Bronchopneumopathie Chronique Obstructive (BPCO): lead
• Clin-Experts: collaborator

Study Sites (7)

Chu Bordeaux

Bordeaux, France

RECRUITING

Chu Lille

Lille, France

RECRUITING

Chu Lille

Lille, France

RECRUITING

Chu Nancy-Brabois

Nancy, France

RECRUITING

Hopital Cochin

Paris, France

RECRUITING

Chu Reims

Reims, France

RECRUITING

Chu Saint Etienne

Saint-Etienne, France

RECRUITING

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Dyspnea

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiration Disorders; Signs and Symptoms, Respiratory; Signs and Symptoms

Study Officials

• Nicolas ROCHE

  HOPITAL COCHIN

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Renaud URBINELLI

CONTACT

+33756882093; etudes@clin-experts.fr

José GARCIA-MACE

CONTACT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 20, 2026
• First Posted: June 4, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): December 31, 2029
• Study Completion (Estimated): December 31, 2029
• Last Updated: June 4, 2026

Record last verified: 2026-05

Locations

FR (7)