Comparison of Rate of Tooth Movement Between MOPs vs MOPs & LLLT Combined

NCT07626580 | Not Yet Recruiting DMC FDA Device

• 1 other identifier: IIDC/IRC/2025 Nauman Arshad
• Study Type: interventional
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

Orthodontic treatment is often prolonged, requiring years to achieve desirable outcomes. The prolonged duration of treatment increases the risk of complications such as root resorption, periodontal damage, and patient non-compliance. To address these concerns, various methods have been explored to accelerate orthodontic tooth movement, including pharmacological agents, mechanical vibration, corticotomies, and minimally invasive techniques like Micro-Osteoperforations (MOPs) and Low-Level Laser Therapy (LLLT). Micro-Osteoperforations (MOPs) have gained popularity as a minimally invasive technique that enhances bone remodeling by inducing a localized inflammatory response, thereby accelerating tooth movement. Studies have shown that MOPs can effectively stimulate the expression of cytokines, increasing osteoclastic activity and facilitating rapid orthodontic tooth movement. However, the extent of its effectiveness varies among individuals, necessitating additional interventions to maximize efficiency. Low-Level Laser Therapy (LLLT), also known as photobiomodulation, is another promising adjunct in orthodontics. LLLT has been reported to enhance cellular activity, promote osteoblastic and osteoclastic function, and improve tissue healing, leading to accelerated tooth movement. Several studies suggest that LLLT alone can expedite orthodontic treatment, but its combination with MOPs has not been extensively explored. This study aims to compare the rate of orthodontic tooth movement between MOPs alone and MOPs combined with LLLT. By evaluating these two techniques, this research seeks to determine whether LLLT enhances the effectiveness of MOPs in accelerating tooth movement. The findings of this study could provide valuable insights into optimizing orthodontic treatment duration while minimizing potential risks and discomfort for patients.

Conditions

Orthodontic Tooth Movement; Canine Retraction; Low Level Laser Therapy

Keywords

Low Level Laser Therapy; LLLT; Micro-Osteoperforations; Canine Retraction; Maxillary Scan

Outcome Measures

Primary Outcomes (1)

• Rate of Tooth Movement

  To compare the rate of orthodontic tooth movement while retraction of Maxillary Canine in extracted first premolar sight between MOPs alone and MOPs combined with LLLT. The mesurements were done on Intraoral scan of Maxilla, before the experiment and after 9 weeks, the MOPs and LLLT were repeated after every 3 weeks.

  3 weeks

Secondary Outcomes (2)

• Root Resorption

  3 weeks

• Pain in each visit

  3 weeks

Study Arms (2)

Right side LLLT + MOP, Left side MOP only

EXPERIMENTAL

Group A will undergo micro-osteoperforations on Left side and Microosteoperforations with Low Level Laser Therapy combined on Right side of the Maxillary Arch

Other: Micro-osteoperforation; Device: Low Level Laser Therapy and Micro-osteoperforations Combined

Right side MOP only, Left side LLLT + MOP

EXPERIMENTAL

Group B will undergo micro-osteoperforations on Right side and Microosteoperforations with Low Level Laser Therapy combined on Leftside of the Maxillary Arch

Other: Micro-osteoperforation; Device: Low Level Laser Therapy and Micro-osteoperforations Combined

Interventions

Micro-osteoperforation OTHER

MOPs will be performed using a sterile surgical instrument under local anesthesia, ensuring patient comfort during the procedure. Small perforations will be created in the alveolar bone adjacent to the tooth undergoing orthodontic movement along the long axis of the tooth with rule of 3, 3mm difference between three sites along the distal root of Canine. The intervention was repeated after 3 weeks interval for 9 weeks. GNI Mini Screws 1.8 x 8 mm

Right side LLLT + MOP, Left side MOP only; Right side MOP only, Left side LLLT + MOP

Low Level Laser Therapy and Micro-osteoperforations Combined DEVICE

Woodpecker LX16 Plus Diode Laser (976± 20nm) will be applied at 5W and Frequency of 10000 Hz for 8 seconds producing a total of 8J Energy. MOPs will be performed using a sterile surgical instrument under local anesthesia, ensuring patient comfort during the procedure. Small perforations will be created in the alveolar bone adjacent to the tooth undergoing orthodontic movement along the long axis of the tooth with rule of 3, 3mm difference between three sites along the distal root of Canine. The intervention was repeated after 3 weeks interval for 9 weeks. GNI Mini Screws 1.8 x 8 mm

Right side LLLT + MOP, Left side MOP only; Right side MOP only, Left side LLLT + MOP

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients aged 12-30 years requiring fixed orthodontic treatment.
• Patients with Class I or mild-to-moderate Class II malocclusion requiring canine retraction.
• No history of previous orthodontic treatment.
• Patients with indications for the extraction of the first premolars on both sides of the maxilla.

You may not qualify if:

• Patients with systemic conditions affecting bone metabolism (e.g., osteoporosis, diabetes).
• Smokers and individuals with poor oral hygiene.
• Pregnant or lactating women.

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Islamic International Dental Hospital

Islamabad, Punjab Province, Pakistan

Location

Related Publications (8)

• Moradinejad M, Chaharmahali R, Shamohammadi M, Mir M, Rakhshan V. Low-level laser therapy, piezocision, or their combination vs. conventional treatment for orthodontic tooth movement : A hierarchical 6-arm split-mouth randomized clinical trial. J Orofac Orthop. 2024 Mar;85(2):110-122. doi: 10.1007/s00056-022-00427-1. Epub 2022 Sep 21.

  PMID: 36129485 BACKGROUND

• Huang CY, Le HHT, Tsai HC, Tang CH, Yu JH. The effect of low-level laser therapy on osteoclast differentiation: Clinical implications for tooth movement and bone density. J Dent Sci. 2024 Jul;19(3):1452-1460. doi: 10.1016/j.jds.2024.03.023. Epub 2024 Mar 30.

  PMID: 39035342 BACKGROUND

• Alzahrani AM, Aljibrin FJ, Alqahtani AM, Saklou R, Alhassan IA, Alamer AH, Al Ameer MH, Hatami MS, Dahhas FY. Photobiomodulation in Orthodontics: Mechanisms and Clinical Efficacy for Faster Tooth Movement. Cureus. 2024 Apr 26;16(4):e59061. doi: 10.7759/cureus.59061. eCollection 2024 Apr.

  PMID: 38800347 BACKGROUND

• Ciobotaru CD, Festila D, Dinte E, Muntean A, Bosca BA, Ionel A, Ilea A. Enhancement of Orthodontic Tooth Movement by Local Administration of Biofunctional Molecules: A Comprehensive Systematic Review. Pharmaceutics. 2024 Jul 25;16(8):984. doi: 10.3390/pharmaceutics16080984.

  PMID: 39204329 BACKGROUND

• Narayan H. Gandedkar, Oyku Dalci, M. Ali Darendeliler, Accelerated orthodontics (AO): The past, present and the future, Seminars in Orthodontics, Volume 30, Issue 2, 2024, Pages 172-182, ISSN 1073-8746, https://doi.org/10.1053/j.sodo.2024.01.012.

  BACKGROUND

• Dipalma, Gianna, Assunta Patano, Irene Ferrara, Fabio Viapiano, Anna Netti, Sabino Ceci, Daniela Azzollini, Anna Maria Ciocia, Giuseppina Malcangi, Alessio Danilo Inchingolo, and et al. 2023. "Acceleration Techniques for Teeth Movements in Extractive Orthodontic Therapy" Applied Sciences 13, no. 17: 9759. https://doi.org/10.3390/app13179759

  BACKGROUND

• Ramseier CA. Diagnostic measures for monitoring and follow-up in periodontology and implant dentistry. Periodontol 2000. 2024 Jun;95(1):129-155. doi: 10.1111/prd.12588. Epub 2024 Jul 1.

  PMID: 38951873 BACKGROUND

• Pattanaik S, Veeraraghavan VP, Dasari AK, Patil SR, Alzahrani SG, Fareed M. Orthodontic treatment in adults: Challenges, outcomes, and factors affecting compliance and satisfaction. J Orthod Sci. 2024 May 8;13:14. doi: 10.4103/jos.jos_186_23. eCollection 2024.

  PMID: 38784082 BACKGROUND

MeSH Terms

Interventions

Low-Level Light Therapy

Intervention Hierarchy (Ancestors)

Laser Therapy; Therapeutics; Phototherapy

Study Officials

• Ulfat Bashir

  Riphah International University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Imran Amjad, Phd

CONTACT

+923324390125; imran.amjad@riphah.edu.pk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 1, 2026
• First Posted: June 4, 2026
• Study Start: June 1, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: June 4, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)