The Relationship Between Measured Creatinine Clearance and Acute Kidney Injury in Critically Ill Patients

NCT07624721 | Completed DMC

• 1 other identifier: ONZ-2025-0607
• Study Type: observational
• Target: 1,416
• Locations: 1 country
• Sites: 1

Brief Summary

With this study, the investigators want to find out how well different stages of acute kidney injury (AKI), match with the actual filtering ability of the kidneys in very sick adults in the intensive care unit (ICU). Kidney function will be measured using a urine test that estimates how much waste the kidneys can clear from the blood. The investigators will also compare two ways of diagnosing and staging AKI: one based on how much urine a person makes, and the other based on blood creatinine levels (a waste product that rises when kidney function worsens). In addition, the investigators will examine how factors that can be changed (such as treatments or medications) and factors that cannot be changed (such as age or existing health conditions) may affect this relationship. Finally, the investigators will look at whether drops in kidney function are linked to problems like high potassium levels in the blood and a buildup of acid in the body.

Conditions

AKI - Acute Kidney Injury

Keywords

intensive care; acute kidney injury

Outcome Measures

Primary Outcomes (1)

• The association between KDIGO AKI stage and measured creatinine clearance.

  During each patient's entire ICU stay, the KDIGO stage will be determined at every time point for which a measured creatinine clearance value is available. As this is a retrospective analysis, the timing and frequency of measured creatinine clearance assessments will vary between patients throughout their ICU stay. Measured creatine clearance will be corrected for body surface area and expressed as mL/min/1.73 m². The KDIGO classification categorizes AKI severity from mild to severe using a scoring system ranging from stage 1 to stage 3.

  from ICU admission until ICU discharge (average 4 days)

Secondary Outcomes (5)

• The association between KDIGO AKI 'urine output criteria' and 'serum creatinine criteria' and the measured creatinine clearance.

  from ICU admission until ICU discharge (average 4 days)

• The association of gender with differences in measured creatinine clearance according to AKI severity.

  from ICU admission until ICU discharge (average 4 days)

• Comparison of measured creatinine clearance in patients with chronic kidney disease (CKD) in the different AKI (KDIGO) stages

  from ICU admission until ICU discharge (average 4 days)

• Association of measured creatinine clearance and KDIGO stage with complications

  from ICU admission until ICU discharge (average 4 days)

• The association between measured creatinine clearance and estimated glomerular filtration rate (eGFR)

  from ICU admission until ICU discharge (average 4 days)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients admitted on the ICU of Ghent Univesity Hospital between 1 December 2024 and 30 November 2025

You may qualify if:

• Admission ICU of Ghent university hospital
• Availability of at least one serum creatinine clearance

You may not qualify if:

• chronic RRT before ICU admission
• RRT during ICU
• Missing or incomplete data preventing KDIGO AKI classification

Sponsors & Collaborators

• University Hospital, Ghent: lead

Study Sites (1)

Ghent university hospital

Ghent, 9000, Belgium

Location

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 20, 2026
• First Posted: June 3, 2026
• Study Start: April 1, 2026
• Primary Completion: April 19, 2026
• Study Completion: April 19, 2026
• Last Updated: June 3, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)