Risk Factors And Outcomes Of Hospital Acquired AKI

NCT06051708 | Completed

• 1 other identifier: Hospiat Acq. AKI
• Study Type: observational
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study is to assess the common risk factors for development of hospital acquired acute kidney injury among hospitalized patients in Alexandria Main University hospital and their outcomes.

Conditions

AKI - Acute Kidney Injury

Keywords

AKI; Hospital Acquired; risk factors; outcomes

Outcome Measures

Primary Outcomes (1)

• Recovery of kidney functions

  (improvement of eGFR, serum creatinine to normal or previous baseline).

  12 weeks

Secondary Outcomes (3)

• progression to chronic kidney disease.

  12 weeks

• mortality

  12 weeks

• Need for renal replacement therapy

  12 weeks

Study Arms (2)

AKI group

patients who are hospitalized and develop acute kidney injury after 48 hours from admission

Other: standard AKI care bundle

no AKI group

patients who are hospitalized and do not develop acute kidney injury after 48 hours from admission till discharge

Other: standard care for hospitalized patients

Interventions

standard AKI care bundle OTHER

AKI care bundle include use of iv fluids, diuretics, antihyperkalemic drugs, sodium bicarbonate, antibiotics in septic patients.

AKI group

standard care for hospitalized patients OTHER

this includes iv fluids, diuretics, antibiotics in septic patients, other measures according to original disease

no AKI group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This research is a prospective cohort study that will include hospitalized patients in Alexandria Main University Hospital (in non-intensive care unit sittings) admitted over a period of sixteen weeks. Patients will be divided into two groups: Group (A) : patients who are hospitalized and develop acute kidney injury after 48 hours from admission. Group (B) : patients who are hospitalized and do not develop acute kidney injury after 48 hours from admission till discharge. All participants will be followed till discharge and after 3 months to assess outcomes.

You may qualify if:

• Fulfilment of definition of acute kidney injury according to KDIGO reference.
• Age more than 18 years.

You may not qualify if:

• Mentally or physically unfit patients.
• Patients who developed acute kidney injury within 48 hours of admission to hospital.

Sponsors & Collaborators

• Alexandria University: lead

Study Sites (1)

Faculty of Medicine, Aexandria University

Alexandria, 21526, Egypt

Location

Related Publications (4)

• Singh TB, Rathore SS, Choudhury TA, Shukla VK, Singh DK, Prakash J. Hospital-acquired acute kidney injury in medical, surgical, and intensive care unit: A comparative study. Indian J Nephrol. 2013 Jan;23(1):24-9. doi: 10.4103/0971-4065.107192.

  PMID: 23580801 BACKGROUND

• Sawhney S, Mitchell M, Marks A, Fluck N, Black C. Long-term prognosis after acute kidney injury (AKI): what is the role of baseline kidney function and recovery? A systematic review. BMJ Open. 2015 Jan 6;5(1):e006497. doi: 10.1136/bmjopen-2014-006497.

  PMID: 25564144 BACKGROUND

• Hsu CN, Lee CT, Su CH, Wang YL, Chen HL, Chuang JH, Tain YL. Incidence, Outcomes, and Risk Factors of Community-Acquired and Hospital-Acquired Acute Kidney Injury: A Retrospective Cohort Study. Medicine (Baltimore). 2016 May;95(19):e3674. doi: 10.1097/MD.0000000000003674.

  PMID: 27175701 BACKGROUND

• Ponce D, Balbi A. Acute kidney injury: risk factors and management challenges in developing countries. Int J Nephrol Renovasc Dis. 2016 Aug 22;9:193-200. doi: 10.2147/IJNRD.S104209. eCollection 2016.

  PMID: 27578995 BACKGROUND

MeSH Terms

Conditions

Acute Kidney Injury

Interventions

Standard of Care

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Quality Indicators, Health Care; Quality of Health Care; Health Services Administration; Health Care Quality, Access, and Evaluation

Study Officials

• Hala S ElWakil, MD

  professor

  PRINCIPAL INVESTIGATOR

• yasmine s naga, MD

  ASS. prof

  STUDY CHAIR

• Mohamed mamdouh Elsayed, MD

  Lecturer

  STUDY CHAIR

• sara R Nagib, MBBCh

  Resident

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: September 17, 2023
• First Posted: September 25, 2023
• Study Start: June 1, 2023
• Primary Completion: April 1, 2024
• Study Completion: May 15, 2024
• Last Updated: June 18, 2024

Record last verified: 2024-06

Locations

EG (1)