NCT07623590

Brief Summary

Patients with acute respiratory distress syndrome are placed on mechanical ventilation, and the adjustment of ventilator parameters is an important step in their care, in particular positive expiratory pressure, applied at the end of breathing. The goal of this study is to learn if continuous anterior chest compression works as well as electrical impedance tomography for positive expiratory pressure titration. Researchers will compare the two methods for each patient, in a randomly determined order : continuous anterior chest compression and electrical impedance tomography. Participants will :

  • have a pep titration with both techniques
  • be included in the study for 28 days

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
9mo left

Started Apr 2025

Typical duration for not_applicable

Geographic Reach
1 country

2 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress64%
Apr 2025May 2027

First Submitted

Initial submission to the registry

November 19, 2024

Completed
5 months until next milestone

Study Start

First participant enrolled

April 7, 2025

Completed
1.2 years until next milestone

First Posted

Study publicly available on registry

June 3, 2026

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 5, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 5, 2027

Last Updated

June 3, 2026

Status Verified

May 1, 2026

Enrollment Period

2.1 years

First QC Date

November 19, 2024

Last Update Submit

May 29, 2026

Conditions

ARDS (Acute Respiratory Distress Syndrome)

Keywords

EITARDSPEEP

Outcome Measures

Primary Outcomes (3)

  • PEPCTAC

    PEPCTAC (unit : cmH2O)

    Day 0

  • PEPCAC

    PEPCAC (unit : cmH2O)

    Day 0

  • PEPEIT

    PEPEIT (unit : cmH2O)

    Day 0

Secondary Outcomes (14)

  • Percentage of collapse at PEPCTAC

    Day 0

  • Percentage of collapse at PEPCAC

    Day 0

  • Percentage of collapse at PEPEIT

    Day 0

  • Compare respiratory mechanics for PEPCTAC and PEPCAC and PEPEIT

    Day 0

  • Compare PEPCTAC and other PEEP adjustment methods reported in the literature

    Day 0

  • +9 more secondary outcomes

Study Arms (1)

PEEP titrations

OTHER
Other: PEEP titrations

Interventions

PEEP titrationsOTHER

Assessment of ideal PEEP using electrical impedance tomography will be performed. The evaluation of PEEP using the thorax compression maneuver method will be carried out. A blood sample (the "blood gases") will be taken at the ideal PEEP determined by electrical impedance tomography and at the ideal PEEP determined by the manual chest compression maneuver.

PEEP titrations

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age ≥ 18 years
  • Moderate to severe ARDS according to the Berlin criteria
  • Patient receiving sedation and continuous curarization
  • Free and informed consent from the patient or their loved one

You may not qualify if:

  • ECMO
  • Pneumothorax
  • Chest trauma in the last 3 months
  • Uncontrolled shock (noradrenaline \> 5 mg/h)
  • Pregnant or breastfeeding woman
  • Protected adult within the meaning of the law
  • Lack of social security
  • Patient under AME

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

GHU Henri Mondor

Créteil, 94000, France

RECRUITING

Hôpital Saint Joseph Saint Luc

Lyon, 69007, France

RECRUITING

MeSH Terms

Conditions

Acute Lung Injury

Condition Hierarchy (Ancestors)

Lung InjuryLung DiseasesRespiratory Tract Diseases

Central Study Contacts

Emmanuel Vivier, MD

CONTACT

+33(0)478618209evivier@saintjosephsaintluc.fr

Fanny Doroszewski, Mrs

CONTACT

+33(0)478618398fdoroszewski@saintjosephsaintluc.fr

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
OTHER
Intervention Model
SINGLE GROUP
Model Details: Assessment of ideal PEEP using electrical impedance tomography will be performed as part of usual care but recorded for research purposes. The evaluation of PEEP using the thorax compression maneuver method will be carried out. A blood sample (the "blood gases") will be taken at the ideal PEEP determined by electrical impedance tomography and at the ideal PEEP determined by the manual chest compression maneuver. All of these evaluations will not exceed three hours. Then, usual care will be continued and no further interventions will be carried out as part of the research. The patient will remain included in the study for 28 days in order to collect their health status on the 28th day.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 19, 2024

First Posted

June 3, 2026

Study Start

April 7, 2025

Primary Completion (Estimated)

May 5, 2027

Study Completion (Estimated)

May 5, 2027

Last Updated

June 3, 2026

Record last verified: 2026-05

Locations

FR(2)